{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:51:18Z","timestamp":1764784278916},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The ability to detect catecholamines (CAs) and their metabolites is vital to understand the mechanism behind the neuronal diseases. Neurochemistry aims to provide an improved pharmacological, molecular and physiological understanding of complex brain chemistries by analytical techniques. Capillary electrophoresis (CE) is one such analytical technique that enables the study of various chemical species ranging from amino acids and peptides to natural products and drugs. CE can easily adapt the changes in research focus and in recent years remains an applicable technique for investigating neuroscience and single cell neurobiology. The prepared phenylalanine-based hydrophobic monolithic column, Polymethacryloyl-L-phenylalanine [PMAPA], was used as a stationary phase in capillary electrochromatography to separate CAs that are similar in size and shape to each other including dopamine (DA) and norepinephrine (NE) via hydrophobic interactions. Separation carried out in a short period of 17\u00a0min was performed with the electrophoretic mobility of 5.54\u00a0\u00d7\u00a010\u22126\u00a0m2\u00a0V\u22121\u00a0s\u22121 and 7.60\u00a0\u00d7\u00a010\u22126\u00a0m2\u00a0V\u22121\u00a0s\u22121 for DA and NE, respectively, at pH\u00a07.0, 65% acetonitrile ratio with 100\u00a0mbar applied pressure by the developed hydrophobic monolithic column without needing any extra process such as imprinting or spacer arms to immobilize ligands used in separation.<\/jats:p>","DOI":"10.1093\/chromsci\/bmz047","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T09:50:24Z","timestamp":1563443424000},"page":"758-765","source":"Crossref","is-referenced-by-count":7,"title":["Polymethacryloyl-L-Phenylalanine [PMAPA]-Based Monolithic Column for Capillary Electrochromatography"],"prefix":"10.1093","volume":"57","author":[{"given":"Ali","family":"Derazshamshir","sequence":"first","affiliation":[{"name":"Department of Chemistry, Hacettepe University, Beytepe, 06800, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcleyman","family":"A\u015f\u0131r","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Nanotechnology Engineering, Near East University, 99138, Nicosia, North Cyprus, Mersin 10, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilg\u0131m","family":"G\u00f6kt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hacettepe University, Beytepe, 06800, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisem","family":"Ektirici","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hacettepe University, Beytepe, 06800, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Chemistry Technology Division, Abant Izzet Baysal University, 14900, Bolu, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Denizli","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hacettepe University, Beytepe, 06800, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"2019091012563854900_ref1","first-page":"1762","article-title":"Capillary zone electrophoresis with electrochemical detection","volume":"59","author":"Wallingford","year":"1987","journal-title":"Analytical Cemistry"},{"key":"2019091012563854900_ref2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.talanta.2016.06.066","article-title":"Electrochemical sensors and biosensors for determination of catecholamine neurotransmitters: a review","volume":"160","author":"Ribeiro","year":"2016","journal-title":"Talanta"},{"issue":"40","key":"2019091012563854900_ref3","doi-asserted-by":"crossref","first-page":"12542","DOI":"10.1523\/JNEUROSCI.2521-09.2009","article-title":"Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and regulates their fasciculation, channeling, rostral growth and intracortical targeting","volume":"29","author":"Kolk","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"2019091012563854900_ref4","first-page":"1","volume-title":"Neurophysiology: a conceptual approach","author":"Carpenter","year":"2013"},{"key":"2019091012563854900_ref5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.snb.2014.10.130","article-title":"Simultaneous electrochemical determination of dopamine, melatonin, methionine and caffeine","volume":"208","author":"Molaakbari","year":"2015","journal-title":"Sensors and Actuators B: Chemical"},{"key":"2019091012563854900_ref6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.electacta.2017.08.076","article-title":"An \u201con-off\u201d electrochemiluminescence biosensor based on molecularly imprinted polymer and recycling amplifications for determination of dopamine","volume":"250","author":"Wang","year":"2017","journal-title":"Electrochimica Acta"},{"key":"2019091012563854900_ref7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.saa.2018.01.062","article-title":"A fluorescent sensor based on thioglycolic acid capped cadmium sulfide quantum dots for the determination of dopamine","volume":"19","author":"Kulchat","year":"2018","journal-title":"Spectrochimica Acta. 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