{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:19:10Z","timestamp":1792811950325,"version":"4.5.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Guidance regarding indications for initial or follow-up blood cultures is limited. We conducted a scoping review of articles published between January 2004 and June 2019 that reported the yield of blood cultures and\/or their impact in the clinical management of fever and common infectious syndromes in nonneutropenic adult inpatients. A total of 2893 articles were screened; 50 were included. Based on the reported incidence of bacteremia, syndromes were categorized into low, moderate, and high pretest probability of bacteremia. Routine blood cultures are recommended in syndromes with a high likelihood of bacteremia (eg, endovascular infections) and those with moderate likelihood when cultures from the primary source of infection are unavailable or when prompt initiation of antibiotics is needed prior to obtaining primary source cultures. In syndromes where blood cultures are low-yield, blood cultures can be considered for patients at risk of adverse events if a bacteremia is missed (eg, patient with pacemaker and severe purulent cellulitis). If a patient has adequate source control and risk factors or concern for endovascular infection are not present, most streptococci or Enterobacterales bacteremias do not require routine follow-up blood cultures.<\/jats:p>","DOI":"10.1093\/cid\/ciaa039","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T20:12:10Z","timestamp":1578946330000},"page":"1339-1347","source":"Crossref","is-referenced-by-count":157,"title":["Does This Patient Need Blood Cultures? A Scoping Review of Indications for Blood Cultures in Adult Nonneutropenic Inpatients"],"prefix":"10.1093","volume":"71","author":[{"given":"Valeria","family":"Fabre","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima L","family":"Sharara","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra B","family":"Salinas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen C","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E","family":"Cosgrove","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"2020082200571959800_CIT0001","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1128\/JCM.01555-07","article-title":"Detection of bloodstream infections in adults: how many blood cultures are needed?","volume":"45","author":"Lee","year":"2007","journal-title":"J Clin Microbiol"},{"key":"2020082200571959800_CIT0002","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/cid\/ciy584","article-title":"A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology","volume":"67","author":"Miller","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2020082200571959800_CIT0003","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s13104-015-1365-8","article-title":"Correlation between mass and volume of collected blood with positivity of blood cultures","volume":"8","author":"Neves","year":"2015","journal-title":"BMC Res Notes"},{"key":"2020082200571959800_CIT0004","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1469-0691.2004.00893.x","article-title":"Repeating blood cultures during hospital stay: practice pattern at a teaching hospital and a proposal for guidelines","volume":"10","author":"Tabriz","year":"2004","journal-title":"Clin Microbiol Infect"},{"key":"2020082200571959800_CIT0005","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/jhm.2541","article-title":"Culture if spikes? 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