{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:05:53Z","timestamp":1791839153230,"version":"4.3.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A persistently low CD4\/CD8 ratio has been reported to inversely correlate with the risk of non-AIDS defining cancer in people living with human immunodeficiency virus (HIV; PLWH) efficiently treated by combination antiretroviral therapy (cART). We evaluated the impact of the CD4\/CD8 ratio on the risk of Kaposi sarcoma (KS) or non-Hodgkin lymphoma (NHL), still among the most frequent cancers in treated PLWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PLWH from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) were included if they achieved virological control (viral load\u2005\u2264\u2005500 copies\/mL) within 9 months following cART and without previous KS\/LNH diagnosis. Cox models were used to identify factors associated with KS or NHL risk, in all participants and those with CD4\u2005\u2265\u2005500\/mm3 at virological control. We analyzed the CD4\/CD8 ratio, CD4 count and CD8 count as time-dependent variables, using spline transformations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 56 708 PLWH, enrolled between 2000 and 2014. At virological control, the median (interquartile range [IQR]) CD4 count, CD8 count, and CD4\/CD8 ratio were 414 (296\u2013552)\/mm3, 936 (670\u20131304)\/mm3, and 0.43 (0.28\u20130.65), respectively. Overall, 221 KS and 187 NHL were diagnosed 9 (2\u201337) and 18 (7\u201342) months after virological control. Low CD4\/CD8 ratios were associated with KS risk (hazard ratio [HR]\u2005=\u20052.02 [95% confidence interval {CI\u2005} =\u20051.23\u20133.31]) when comparing CD4\/CD8\u2005=\u20050.3 to CD4\/CD8\u2005=\u20051) but not with NHL risk. High CD8 counts were associated with higher NHL risk (HR\u2005=\u20053.14 [95% CI\u2005=\u20051.58\u20136.22]) when comparing CD8\u2005=\u20053000\/mm3 to CD8\u2005=\u20051000\/mm3). Similar results with increased associations were found in PLWH with CD4\u2005\u2265\u2005500\/mm3 at virological control (HR\u2005=\u20053.27 [95% CI\u2005=\u20051.60\u20136.56] for KS; HR\u2005=\u20055.28 [95% CI\u2005=\u20052.17\u201312.83] for NHL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low CD4\/CD8 ratios and high CD8 counts despite effective cART were associated with increased KS\/NHL risks respectively, especially when CD4\u2005\u2265\u2005500\/mm3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaa1137","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T07:54:12Z","timestamp":1596441252000},"page":"50-59","source":"Crossref","is-referenced-by-count":42,"title":["CD4\/CD8 Ratio and the Risk of Kaposi Sarcoma or Non-Hodgkin Lymphoma in the Context of Efficiently Treated Human Immunodeficiency Virus (HIV) Infection: A Collaborative Analysis of 20 European Cohort Studies"],"prefix":"10.1093","volume":"73","author":[{"given":"Fabienne","family":"Caby","sequence":"first","affiliation":[{"name":"Unit\u00e9 VIH-IST, Service d\u2019Immuno-H\u00e9matologie, H\u00f4pital Victor Dupouy, Argenteuil, France"},{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique (IPLESP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Guiguet","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique (IPLESP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Weiss","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Paris Centre H\u00f4tel Dieu, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Winston","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M","family":"Miro","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital Clinic\u2014IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Konopnicki","sequence":"additional","affiliation":[{"name":"St Pierre University Hospital, Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Le Moing","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, University Hospital of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Bonnet","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux and INSERM U1219, ISPED, Universit\u00e9 de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Reiss","sequence":"additional","affiliation":[{"name":"HIV Monitoring Foundation, Amsterdam, The Netherlands, and Department of Global Health, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mussini","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Poizot-Martin","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, APHM, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, H\u00f4pital Sainte- Marguerite, Service d\u2019Immuno-h\u00e9matologie clinique, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninon","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Paracelsus Private Medical University Salzburg, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Skoutelis","sequence":"additional","affiliation":[{"name":"5th Department of Medicine and Infectious Diseases \u201cEvangelismos\u201d General Hospital of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Meyer","sequence":"additional","affiliation":[{"name":"INSERM CESP U1018, Universit\u00e9 Paris-Saclay, APHP Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Goujard","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine interne et d\u2019Immunologie clinique, AP-HP Universit\u00e9 Paris-Saclay, H\u00f4pital Bic\u00eatre, Facult\u00e9 de M\u00e9decine\u2013Universit\u00e9 Paris-Saclay, Centre de recherche en \u00e9pid\u00e9miologie et sant\u00e9 des populations CESP-Inserm U1018, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bartmeyer","sequence":"additional","affiliation":[{"name":"Robert Koch Institute, Department of Infectious Disease Epidemiology, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Boesecke","sequence":"additional","affiliation":[{"name":"German Centre for Infection Research, Cologne-Bonn; Department of Medicine I, Bonn University Hospital, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Antinori","sequence":"additional","affiliation":[{"name":"HIV\/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Quiros-Roldan","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, Universit\u00e1 degli Studi di Brescia, ASST Spedali Civili di Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Wittkop","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bordeaux, ISPED, Inserm, Bordeaux Population Health Research Center, Team MORPH3EUS, UMR 1219, Bordeaux, France"},{"name":"CHU de Bordeaux, P\u00f4le de sant\u00e9 publique, Service d\u2019information m\u00e9dicale, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Section of Forensic Genetics, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Castagna","sequence":"additional","affiliation":[{"name":"Vita-Salute San Raffaele University, IRCC San Raffaele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Christine","family":"Thurnheer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University Hospital Berne, University of Berne, Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Svedhem","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Karolinska University Hospital and Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Jose","sequence":"additional","affiliation":[{"name":"Transforming Cancer Services Team-Public Health England Partnership, National Cancer Registration and Analysis Service, Wellington House, London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Costagliola","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique (IPLESP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle","family":"Mary-Krause","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique (IPLESP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Grabar","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique (IPLESP), Paris, France"},{"name":"Universit\u00e9 de Paris, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Unit\u00e9 de Biostatistique et Epid\u00e9miologie, H\u00f4pital cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"(CD4\/CD8 ratio and cancer risk) project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Judd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zangerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giota","family":"Touloumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Warszawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Dabis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle Mary","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Ghosn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Leport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Wittkop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Prins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Gibb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"F\u00e4tkenheuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Del Amo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Obel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Thorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Mocroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"P\u00e9rez-Hoyos,","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamah","family":"Hamouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bartmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoloz","family":"Chkhartishvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Noguera-Julian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Antinori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella d\u2019Arminio","family":"Monforte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Brockmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Rojo","family":"Conejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Soriano-Arandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Battegay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Kouyos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mussini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Casabona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Konopnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Goetghebuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"S\u00f6nnerborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Torti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Sabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Teira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Haerry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"2021070111033108700_CIT0001","doi-asserted-by":"crossref","first-page":"e288","DOI":"10.1016\/S2352-3018(15)00077-6","article-title":"Time trends for risk of severe age-related diseases in individuals with and without HIV infection in Denmark: a nationwide population-based cohort study","volume":"2","author":"Rasmussen","year":"2015","journal-title":"Lancet HIV"},{"key":"2021070111033108700_CIT0002","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/cid\/ciu701","article-title":"Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study","volume":"59","author":"Schouten","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2021070111033108700_CIT0003","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1093\/cid\/cit497","article-title":"Risk of AIDS-defining cancers among HIV-1-infected patients in France between 1992 and 2009: results from the FHDH-ANRS CO4 cohort","volume":"57","author":"Hleyhel","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2021070111033108700_CIT0004","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/QAD.0000000000000815","article-title":"Residual immune activation in combined antiretroviral therapy-treated patients with maximally suppressed viremia","volume":"30","author":"Guihot","year":"2016","journal-title":"AIDS"},{"key":"2021070111033108700_CIT0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/01.qai.0000437171.00504.41","article-title":"Associations of inflammatory markers with AIDS and non-AIDS clinical events after initiation of antiretroviral therapy: AIDS clinical trials group A5224s, a substudy of ACTG A5202","volume":"65","author":"McComsey","year":"2014","journal-title":"J Acquir Immune Defic Syndr 1999"},{"key":"2021070111033108700_CIT0006","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/hiv.12310","article-title":"Immune activation in the course of HIV-1 infection: causes, phenotypes and persistence under therapy","volume":"17","author":"Younas","year":"2016","journal-title":"HIV Med"},{"key":"2021070111033108700_CIT0007","first-page":"81","article-title":"The revival of an \u201cold\u201d marker: CD4\/CD8 ratio","volume":"19","author":"Bruno","year":"2017","journal-title":"AIDS Rev"},{"key":"2021070111033108700_CIT0008","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.1302596","article-title":"Multiparametric bioinformatics distinguish the CD4\/CD8 ratio as a suitable laboratory predictor of combined T cell pathogenesis in HIV infection","volume":"192","author":"Buggert","year":"2014","journal-title":"J Immunol"},{"key":"2021070111033108700_CIT0009","doi-asserted-by":"crossref","first-page":"20052","DOI":"10.7448\/IAS.18.1.20052","article-title":"CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients","volume":"18","author":"Lu","year":"2015","journal-title":"J Int AIDS Soc"},{"key":"2021070111033108700_CIT0010","doi-asserted-by":"crossref","first-page":"e1004078","DOI":"10.1371\/journal.ppat.1004078","article-title":"HIV-infected individuals with low CD4\/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality","volume":"10","author":"Serrano-Villar","year":"2014","journal-title":"PLoS Pathog"},{"key":"2021070111033108700_CIT0011","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/cid\/cix466","article-title":"CD4:CD8 ratio and CD8 count as prognostic markers for mortality in human immunodeficiency virus-infected patients on antiretroviral therapy: The Antiretroviral Therapy Cohort Collaboration (ART-CC)","volume":"65","author":"Trickey","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2021070111033108700_CIT0012","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1016\/S2352-3018(15)00006-5","article-title":"CD4\/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study","volume":"2","author":"Mussini","year":"2015","journal-title":"Lancet HIV"},{"key":"2021070111033108700_CIT0013","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1016\/S2352-3018(16)30215-6","article-title":"Immunological and infectious risk factors for lung cancer in US veterans with HIV: a longitudinal cohort study","volume":"4","author":"Sigel","year":"2017","journal-title":"Lancet HIV"},{"key":"2021070111033108700_CIT0014","doi-asserted-by":"crossref","first-page":"e0161594","DOI":"10.1371\/journal.pone.0161594","article-title":"Low CD4\/CD8 ratio is associated with non AIDS-defining cancers in patients on antiretroviral therapy: ANRS CO8 (Aproco\/Copilote) Prospective Cohort Study","volume":"11","author":"Hema","year":"2016","journal-title":"PLoS One"},{"key":"2021070111033108700_CIT0015","doi-asserted-by":"crossref","first-page":"e495","DOI":"10.1016\/S2352-3018(17)30125-X","article-title":"Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study","volume":"4","author":"Hern\u00e1ndez-Ram\u00edrez","year":"2017","journal-title":"Lancet HIV"},{"key":"2021070111033108700_CIT0016","doi-asserted-by":"crossref","first-page":"866","DOI":"10.7326\/M17-2499","article-title":"Projected cancer incidence rates and burden of incident cancer cases in HIV-infected adults in the United States through 2030","volume":"168","author":"Shiels","year":"2018","journal-title":"Ann Intern Med"},{"key":"2021070111033108700_CIT0017","first-page":"e8","article-title":"Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries","volume":"65","author":"Avila","year":"2014","journal-title":"J Acquir Immune Defic Syndr 1999"},{"key":"2021070111033108700_CIT0018","first-page":"797","article-title":"Cohort profile: Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord","volume":"46","author":"Ch\u00eane","year":"2017","journal-title":"Int J Epidemiol"},{"key":"2021070111033108700_CIT0019","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1177\/135965350400900421","article-title":"HIV cohort collaborations: proposal for harmonization of data exchange","volume":"9","author":"Kjaer","year":"2004","journal-title":"Antivir Ther"},{"key":"2021070111033108700_CIT0020","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-19425-7","volume-title":"Regression modeling strategies: with applications to linear models, logistic and ordinal regression, and survival analysis","author":"Harrell","year":"2015"},{"key":"2021070111033108700_CIT0021","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1097\/QAI.0000000000001221","article-title":"Brief report: assessing and interpreting the association between continuous covariates and outcomes in observational studies of HIV Using splines","volume":"74","author":"Shepherd","year":"2017","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2021070111033108700_CIT0022","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1093\/cid\/ciw562","article-title":"Changing incidence and risk factors for Kaposi sarcoma by time since starting antiretroviral therapy: collaborative analysis of 21 European Cohort Studies","volume":"63","author":"Cancer Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study in EuroCoord.","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2021070111033108700_CIT0023","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/cid\/cix480","article-title":"Comparison of Kaposi sarcoma risk in human immunodeficiency virus-positive adults across 5 continents: a multiregional multicohort study","volume":"65","author":"AIDS-defining Cancer Project Working Group for IeDEA and COHERE in EuroCoord.","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2021070111033108700_CIT0024","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1200\/JCO.2016.67.6999","article-title":"Changes in clinical context for Kaposi\u2019s sarcoma and non-Hodgkin lymphoma among people with HIV infection in the United States","volume":"34","author":"Yanik","year":"2016","journal-title":"J Clin Oncol"},{"key":"2021070111033108700_CIT0025","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/QAD.0b013e3283601144","article-title":"Immunosenescence is associated with presence of Kaposi\u2019s sarcoma in antiretroviral treated HIV infection","volume":"27","author":"Unemori","year":"2013","journal-title":"AIDS"},{"key":"2021070111033108700_CIT0026","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1746-1596-3-31","article-title":"Histological variants of cutaneous Kaposi sarcoma","volume":"3","author":"Grayson","year":"2008","journal-title":"Diagn Pathol"},{"key":"2021070111033108700_CIT0027","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1086\/507648","article-title":"Low T cell responses to human herpesvirus 8 in patients with AIDS-related and classic Kaposi sarcoma","volume":"194","author":"Guihot","year":"2006","journal-title":"J Infect Dis"},{"key":"2021070111033108700_CIT0028","article-title":"HIV-associated lymphoma in the era of combination antiretroviral therapy: shifting the immunological landscape","volume":"73:ftv044","author":"Carroll","year":"2015","journal-title":"Pathog Dis"},{"key":"2021070111033108700_CIT0029","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/cid\/ciu076","article-title":"HIV viremia and incidence of non-Hodgkin lymphoma in patients successfully treated with antiretroviral therapy","volume":"58","author":"Achenbach","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2021070111033108700_CIT0030","doi-asserted-by":"crossref","first-page":"pky082","DOI":"10.1093\/jncics\/pky082","article-title":"Markers of immune activation and inflammation, and non-Hodgkin lymphoma: a meta-analysis of prospective studies","volume":"2","author":"Makgoeng","year":"2018","journal-title":"JNCI Cancer Spectr"},{"key":"2021070111033108700_CIT0031","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1182\/blood-2015-11-681411","article-title":"A lymphomagenic role for HIV beyond immune suppression?","volume":"127","author":"Dolcetti","year":"2016","journal-title":"Blood"},{"key":"2021070111033108700_CIT0032","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/QAD.0000000000000980","article-title":"CD4+ and CD8+ T-cell kinetics in aviremic HIV-infected patients developing Hodgkin or non-Hodgkin lymphoma","volume":"30","author":"Hoffmann","year":"2016","journal-title":"AIDS"},{"key":"2021070111033108700_CIT0033","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/hiv.12546","article-title":"The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people","volume":"19","author":"Shepherd","year":"2018","journal-title":"HIV Med"},{"key":"2021070111033108700_CIT0034","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1158\/1055-9965.EPI-11-0037","article-title":"B-cell stimulatory cytokines and markers of immune activation are elevated several years prior to the diagnosis of systemic AIDS-associated non-Hodgkin B-cell lymphoma","volume":"20","author":"Breen","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2021070111033108700_CIT0035","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1182\/blood-2007-03-080648","article-title":"Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8-specific CD8+ T cells","volume":"111","author":"Guihot","year":"2008","journal-title":"Blood"},{"key":"2021070111033108700_CIT0036","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/QAD.0000000000001533","article-title":"CD4+\/CD8+ ratio restoration in long-term treated HIV-1-infected individuals","volume":"31","author":"Caby","year":"2017","journal-title":"AIDS"},{"key":"2021070111033108700_CIT0037","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/infdis\/jiu669","article-title":"Course and clinical significance of CD8+ T-cell counts in a large cohort of HIV-infected individuals","volume":"211","author":"Helleberg","year":"2015","journal-title":"J Infect Dis"},{"key":"2021070111033108700_CIT0038","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/QAI.0000000000001913","article-title":"Determinants of restoration of CD4 and CD8 cell counts and their ratio in HIV-1-positive individuals with sustained virological suppression on antiretroviral therapy","volume":"80","author":"Gras","year":"2019","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2021070111033108700_CIT0039","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/cid\/ciw076","article-title":"Determinants of a low CD4\/CD8 ratio in HIV-1-infected individuals despite long-term viral suppression","volume":"62","author":"Caby","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2021070111033108700_CIT0040","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/cid\/cit423","article-title":"Opportunistic Infections Working Group on behalf of the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study in EuroCOORD. The incidence of AIDS-defining illnesses at a current CD4 count \u2265200 cells\/\u03bcL in the post-combination antiretroviral therapy era","volume":"57","author":"Mocroft","year":"2013","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa1137\/36297820\/ciaa1137.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/73\/1\/50\/38846791\/ciaa1137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/73\/1\/50\/38846791\/ciaa1137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T10:37:55Z","timestamp":1667644675000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/73\/1\/50\/5880596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,8,4]]},"published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa1137","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7,1]]},"published":{"date-parts":[[2020,8,4]]}}}