{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:17:56Z","timestamp":1762341476910,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2020kfyXGYJ066"],"award-info":[{"award-number":["2020kfyXGYJ066"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We aimed to describe the epidemiological, virological, and serological features of coronavirus disease 2019 (COVID-19) cases in people living with human immunodeficiency virus (HIV; PLWH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This population-based cohort study identified all COVID-19 cases among all PLWH in Wuhan, China, by 16 April 2020. The epidemiological, virological, and serological features were analyzed based on the demographic data, temporal profile of nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the disease, and SARS-CoV-2\u2013specific immunoglobin (Ig) M and G after recovery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From 1 January to 16 April 2020, 35 of 6001 PLWH experienced COVID-19, with a cumulative incidence of COVID-19 of 0.58% (95% confidence interval [CI], .42\u2013.81%). Among the COVID-19 cases, 15 (42.86) had severe illness, with 2 deaths. The incidence, case-severity, and case-fatality rates of COVID-19 in PLWH were comparable to those in the entire population in Wuhan. There were 197 PLWH who had discontinued combination antiretroviral therapy (cART), 4 of whom experienced COVID-19. Risk factors for COVID-19 were age\u2005\u226550 years old and cART discontinuation. The median duration of SARS-CoV-2 viral shedding among confirmed COVID-19 cases in PLWH was 30 days (interquartile range, 20\u201346). Cases with high HIV viral loads (\u226520 copies\/mL) had lower IgM and IgG levels than those with low HIV viral loads (&amp;lt;20 copies\/ml; median signal value divided by the cutoff value [S\/CO] for IgM, 0.03 vs 0.11, respectively [P\u2005&amp;lt;\u2005.001]; median S\/CO for IgG, 10.16 vs 17.04, respectively [P\u2005=\u2005.069]).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Efforts are needed to maintain the persistent supply of antiretroviral treatment to elderly PLWH aged 50 years or above during the COVID-19 epidemic. The coinfection of HIV and SARS-CoV-2 might change the progression and prognosis of COVID-19 patients in PLWH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa1186","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T19:36:47Z","timestamp":1597088207000},"page":"e2086-e2094","source":"Crossref","is-referenced-by-count":68,"title":["Epidemiological, Virological and Serological Features of Coronavirus Disease 2019 (COVID-19) Cases in People Living With Human Immunodeficiency Virus in Wuhan: A Population-based Cohort Study"],"prefix":"10.1093","volume":"73","author":[{"given":"Jiao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nianhua","family":"Xie","sequence":"additional","affiliation":[{"name":"Department for HIV\/AIDS Control and Prevention, Wuhan Center for Disease Control and Prevention, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department for HIV\/AIDS Control and Prevention, Wuhan Center for Disease Control and Prevention, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Yan","sequence":"additional","affiliation":[{"name":"Department for HIV\/AIDS Control and Prevention, Wuhan Center for Disease Control and Prevention, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[{"name":"Department for HIV\/AIDS Control and Prevention, Wuhan Center for Disease Control and Prevention, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pulin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department for HIV\/AIDS Control and Prevention, Wuhan Center for Disease Control and Prevention, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department for HIV\/AIDS Control and Prevention, Wuhan Center for Disease Control and Prevention, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianguo","family":"Ruan","sequence":"additional","affiliation":[{"name":"Jin Yin-tan Hospital, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan Center for Disease Control and Prevention, Wuhan, 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