{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:16:18Z","timestamp":1789060578246,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1076006"],"award-info":[{"award-number":["GNT1076006"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kimberly-Clark Professional"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The relationship between acute myocardial infarction and infection was recognized in the early 20th century during influenza epidemics. Most recently, a case control study and a self-control design study have identified an association between Staphylococcus aureus infection and acute myocardial infarction. We assessed the association of community-acquired Staphylococcus aureus bloodstream infection (CA-SABSI) and myocardial infarction in the 365 days following blood culture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a cohort study assessing the incidence of myocardial infarction 365 days after blood culture for Staphylococcus aureus. Culture-negative patients had blood cultures collected at hospital attendance and were matched to the CA-SABSI participants by sex, 5-year age strata, and year of culture collection. Pathology information was linked to hospital administrative data and index of relative socioeconomic advantage and disadvantage (ISRAD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study included 5157 CA-SABSI cases matched to 10 146 blood culture\u2013negative cases. The mortality rate was significantly higher in the CA-SABSI group (10.9%; 562\/5157) than in culture-negative cases (5.1%; 521\/10 146) at 365 days (P\u2005&amp;lt;\u2005.0001). In the 7 days following the index blood culture, excluding recurrent events, there were 89 (1.7%) and 37 (.4%) myocardial infarction diagnoses in the CA-SABSI and culture-negative cases, respectively. Multivariable logistic regression for myocardial infarction demonstrated a significant association with CA-SABSI after adjusting for known risk factors (odds ratio [OR], 5; 95% confidence interval [CI], 3.3\u20137.5; P\u2005&amp;lt;\u2005.0001). Myocardial infarctions occurring in this short-term risk period were associated with all-cause mortality in a Cox proportional hazard model (OR, 1.7; 95% CI, 1.2\u20132.4; P\u2005&amp;lt;\u2005.005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CA-SABSI is associated with an increased short-term risk of myocardial infarction, which is associated with subsequent mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa1197","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T11:35:19Z","timestamp":1597232119000},"page":"e2647-e2655","source":"Crossref","is-referenced-by-count":6,"title":["Acute Myocardial Infarction and Community-acquired <i>Staphylococcus aureus<\/i> Bloodstream Infection: An Observational Cohort Study"],"prefix":"10.1093","volume":"73","author":[{"given":"John F","family":"McNamara","sequence":"first","affiliation":[{"name":"University of Queensland Centre for Clinical Research, Brisbane, Australia"},{"name":"The Department of Infectious Diseases, The Prince Charles Hospital, Brisbane, Pathology Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick N A","family":"Harris","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research, Brisbane, Australia"},{"name":"Royal Brisbane and Women\u2019s Hospital, Herston, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D","family":"Chatfield","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Paterson","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research, Brisbane, 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