{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:39:51Z","timestamp":1773185991817,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Prosthetic joints are at risk of becoming infected during an episode of bacteremia, especially during Staphylocococcus aureus bacteremia. However, it is unclear how often asymptomatic periprosthetic joint infection (PJI) occurs, and whether additional diagnostics should be considered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this multicenter study, we retrospectively analyzed a cohort of patients with a late acute (hematogenous) PJI between 2005\u20132015 who had concomitant prosthetic joints in situ. Patients without at least 1 year of follow-up were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 91 patients with a hematogenous PJI and 108 concomitant prosthetic joints. The incident PJI was most frequently caused by Staphylococcus aureus (43%), followed by streptococci (26%) and Gram-negative rods (18%). Of 108 concomitant prosthetic joints, 13 were symptomatic, of which 10 were subsequently diagnosed as a second PJI. Of the 95 asymptomatic prosthetic joints, 1 PJI developed during the follow-up period and was classified as a \u201cmissed\u201d PJI at the time of bacteremia with S. aureus (1.1%). Infected prosthetic joints were younger than the noninfected ones in 67% of cases, and prosthetic knees were affected more often than prosthetic hips (78%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>During an episode of hematogenous PJI, concomitant asymptomatic prosthetic joints have a very low risk of being infected, and additional diagnostic work-up for these joints is not necessary.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa1222","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T19:31:29Z","timestamp":1597692689000},"page":"e3820-e3824","source":"Crossref","is-referenced-by-count":21,"title":["How to Handle Concomitant Asymptomatic Prosthetic Joints During an Episode of Hematogenous Periprosthetic Joint Infection, a Multicenter Analysis"],"prefix":"10.1093","volume":"73","author":[{"given":"Marjan","family":"Wouthuyzen-Bakker","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen , the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Sebillotte","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Intensive Care Medicine, Rennes University Hospital , Rennes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9dric","family":"Arvieux","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Intensive Care Medicine, Rennes University Hospital , Rennes , France"},{"name":"Great West Reference centers for Complex Bone and Joint Infections (CRIOGO) , Rennes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Fernandez-Sampedro","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases, Hospital Universitario Marque\u0301s de Valdecilla, University of Cantabria, Instituto de investigaci\u00f3n sanitaria Valdecilla (IDIVAL) , Santander , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Senneville","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Lille, University Hospital Gustave Dron Hospital , Tourcoing , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Maria","family":"Barbero","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine. Hospital Universitario Principe de Asturias , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Lora-Tamayo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine. Hospital Universitario 12 de Octubre. Instituto de Investigaci\u00f3n i+12 . Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Aboltins","sequence":"additional","affiliation":[{"name":"The Department of Infectious Diseases, Northern Health , Melbourne , Australia"},{"name":"The University of Melbourne, Northern Clinical School , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rihard","family":"Trebse","sequence":"additional","affiliation":[{"name":"Service for Bone Infections, Valdoltra Orthopaedic Hospital, the Faculty of Medicine, University of Ljublijana , Ankaran , Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro Jos\u00e9","family":"Salles","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences and Musculoskeletal infection group, Federal University of S\u00e3o Paulo , Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias Siegfried","family":"Kramer","sequence":"additional","affiliation":[{"name":"Institute for hygiene and environmental medicine Charit\u00e9-Universit\u00e4tsmedizin Berlin , Germany"},{"name":"Evangelisches Waldkrankenhaus Spandau , Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University , Milan , Italy"},{"name":"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital , Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Garcia-Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Emergency, Instituto de Investigaci\u00f3n Sanitaria (IIS)-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid (UAM) , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natividad","family":"Benito","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau , Barcelona , Spain"},{"name":"Department of Medicine. Universitat Aut\u00f2noma de Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicens","family":"Diaz-Brito","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Parc Sanitari Sant Joan de Deu , Sant Boi, Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Dolores","family":"del Toro","sequence":"additional","affiliation":[{"name":"Unidad Cl\u00ednica de Enfermedades Infecciosa y Microbiolog\u00eda. Universidad de Sevilla. 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