{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:50:45Z","timestamp":1793141445472,"version":"4.5.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cytomegalovirus (CMV) is the most common opportunistic pathogen, following solid organ transplantation (SOT), that leads to direct and indirect effects. The aim of this study was to assess the impact of CMV exposure at transplantation on the rate of posttransplant thrombotic events (TEs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective cohort study of patients transplanted at the University of Alberta Hospital between July 2005 and January 2018. We included adult SOT CMV-seronegative recipients at transplantation who received an allograft from either a seropositive donor (D+\/R-) or a seronegative donor (D-\/R-).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 392 SOT recipients were included: 151 (39%) liver, 188 (48%) kidney, 45 (11%) pancreas, and 8 (2%) other transplants. The mean age was 47 years, 297 (76%) were males, and 181 (46%) had a CMV D+\/R- donor. Patients in the CMV D+\/R- cohort were slightly older (51 years versus 48 years in the D-\/R- cohort; P\u2005=\u2005.036), while other variables, including cardiovascular risk factors and pretransplant TEs, were not different between groups. Overall, TEs occurred in 35 (19%) patients in the CMV D+\/R- group, versus 21 (10%) in the CMV D-\/R- group, at 5 years of follow-up (P\u2005=\u2005.008); the incidence rates per 100 transplant months were 5.12 and 1.02 in the CMV D+\/R- and CMV D-\/R- groups, respectively (P\u2005=\u2005.003). After adjusting for potential confounders with a Cox regression model, a CMV D+\/R- transplantation was independently associated with an increased risk of a TE over 5 years (adjusted hazard ratio, 3.027; 95% confidence interval, 1.669\u20135.488).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A CMV D+\/R- transplantation is associated with an increased risk of a TE posttransplantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa125","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T12:10:17Z","timestamp":1580904617000},"page":"845-852","source":"Crossref","is-referenced-by-count":15,"title":["Donor Graft Cytomegalovirus Serostatus and the Risk of Arterial and Venous Thrombotic Events in Seronegative Recipients After Non-Thoracic Solid Organ Transplantation"],"prefix":"10.1093","volume":"72","author":[{"given":"Sara","family":"Belga","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"},{"name":"Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dima","family":"Kabbani","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soroush","family":"Shojai","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan G","family":"Abraldes","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cervera","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"2021030519525700300_CIT0001","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/rmv.1862","article-title":"Cytomegalovirus latency and reactivation: recent insights into an age old problem","volume":"26","author":"Dupont","year":"2016","journal-title":"Rev Med Virol"},{"key":"2021030519525700300_CIT0002","first-page":"103","article-title":"Complement-fixing antibodies against cytomegalovirus in different parts of the world","volume":"49","author":"Krech","year":"1973","journal-title":"Bull World Health Organ"},{"key":"2021030519525700300_CIT0003","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/01.qco.0000136933.67920.dd","article-title":"Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients","volume":"17","author":"Pereyra","year":"2004","journal-title":"Curr Opin Infect Dis"},{"key":"2021030519525700300_CIT0004","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/archinte.1979.03630400011006","article-title":"Cytomegalovirus: the troll of transplantation","volume":"139","author":"Balfour","year":"1979","journal-title":"Arch Intern Med"},{"key":"2021030519525700300_CIT0005","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/j.1600-6143.2004.00505.x","article-title":"Cytomegalovirus and lung transplantation","volume":"4","author":"Zamora","year":"2004","journal-title":"Am J Transplant"},{"key":"2021030519525700300_CIT0006","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nri2318","article-title":"Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections","volume":"8","author":"Nikolich-Zugich","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"2021030519525700300_CIT0007","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1128\/JVI.01262-06","article-title":"The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire","volume":"81","author":"Pourgheysari","year":"2007","journal-title":"J Virol"},{"key":"2021030519525700300_CIT0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2013.00271","article-title":"Human T cell aging and the impact of persistent viral infections","volume":"4","author":"F\u00fcl\u00f6p","year":"2013","journal-title":"Front Immunol"},{"key":"2021030519525700300_CIT0009","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00430-019-00605-w","article-title":"Impact of CMV upon immune aging: facts and fiction","volume":"208","author":"Jergovi\u0107","year":"2019","journal-title":"Med Microbiol Immunol"},{"key":"2021030519525700300_CIT0010","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/cmi.2014.93","article-title":"Senescent cytotoxic T cells in acute myocardial infarction: innocent bystanders or the horsemen of apocalypse?","volume":"12","author":"Hoffmann","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"2021030519525700300_CIT0011","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fimmu.2019.00078","article-title":"Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection","volume":"10","author":"Clement","year":"2019","journal-title":"Front Immunol"},{"key":"2021030519525700300_CIT0012","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.micinf.2003.09.024","article-title":"Cytomegalovirus infection aggravates atherogenesis in apoE knockout mice by both local and systemic immune activation","volume":"6","author":"Vliegen","year":"2004","journal-title":"Microbes Infect"},{"key":"2021030519525700300_CIT0013","first-page":"563","article-title":"Cytomegalovirus nucleic acid distribution within the human vascular tree","volume":"138","author":"Hendrix","year":"1991","journal-title":"Am J Pathol"},{"key":"2021030519525700300_CIT0014","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/jmv.1890420213","article-title":"Cytomegalovirus DNA in arterial walls of patients with atherosclerosis","volume":"42","author":"Melnick","year":"1994","journal-title":"J Med Virol"},{"key":"2021030519525700300_CIT0015","doi-asserted-by":"crossref","first-page":"E134","DOI":"10.1086\/374664","article-title":"Vascular thrombosis and acute cytomegalovirus infection in immunocompetent patients: report of 2 cases and literature review","volume":"36","author":"Abgueguen","year":"2003","journal-title":"Clin Infect Dis"},{"key":"2021030519525700300_CIT0016","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/01.CIR.101.1.11","article-title":"Previous cytomegalovirus infection and risk of coronary thrombotic events after stent placement","volume":"101","author":"Neumann","year":"2000","journal-title":"Circulation"},{"key":"2021030519525700300_CIT0017","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1161\/01.CIR.94.5.922","article-title":"Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis","volume":"94","author":"Nieto","year":"1996","journal-title":"Circulation"},{"key":"2021030519525700300_CIT0018","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1001\/archinte.160.13.2027","article-title":"A prospective study of cytomegalovirus, herpes simplex virus 1, and coronary heart disease: the atherosclerosis risk in communities (ARIC) study","volume":"160","author":"Sorlie","year":"2000","journal-title":"Arch Intern Med"},{"key":"2021030519525700300_CIT0019","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/01.CIR.0000044940.65226.1F","article-title":"Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) study","volume":"107","author":"Smieja","year":"2003","journal-title":"Circulation"},{"key":"2021030519525700300_CIT0020","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/aje\/kwq177","article-title":"Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up","volume":"172","author":"Roberts","year":"2010","journal-title":"Am J Epidemiol"},{"key":"2021030519525700300_CIT0021","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/01.TP.0000109779.36669.0D","article-title":"Cytomegalovirus-associated venous thromboembolism in renal transplant recipients: a report of 7 cases","volume":"77","author":"Kazory","year":"2004","journal-title":"Transplantation"},{"key":"2021030519525700300_CIT0022","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/MAJ.0b013e31812f5ba5","article-title":"Association between cytomegalovirus infection and venous thromboembolism","volume":"334","author":"Fridlender","year":"2007","journal-title":"Am J Med Sci"},{"key":"2021030519525700300_CIT0023","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1086\/319353","article-title":"Acute cytomegalovirus infection complicated by vascular thrombosis: a case report","volume":"32","author":"Ofotokun","year":"2001","journal-title":"Clin Infect Dis"},{"key":"2021030519525700300_CIT0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-0711-4-11","article-title":"Acute cytomegalovirus infection complicated by venous thrombosis: a case report","volume":"4","author":"Rovery","year":"2005","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"2021030519525700300_CIT0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.revmed.2005.08.013","article-title":"Portal thrombosis complicating an acute cytomegalovirus infection in an immunocompetent patient","volume":"27","author":"Chelbi","year":"2006","journal-title":"Rev Med Interne"},{"key":"2021030519525700300_CIT0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-230X-6-10","article-title":"Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary infection: a case report","volume":"6","author":"Spahr","year":"2006","journal-title":"BMC Gastroenterol"},{"key":"2021030519525700300_CIT0027","doi-asserted-by":"crossref","first-page":"692","DOI":"10.4254\/wjh.v5.i12.692","article-title":"Acute cytomegalovirus infection in liver transplant recipients: An independent risk for venous thromboembolism","volume":"5","author":"Edula","year":"2013","journal-title":"World J Hepatol"},{"key":"2021030519525700300_CIT0028","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00042737-200604000-00021","article-title":"Acute portal and mesenteric thrombosis: unusual presentation of cytomegalovirus infection","volume":"18","author":"Amitrano","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2021030519525700300_CIT0029","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s11239-008-0303-1","article-title":"Pulmonary embolism and portal vein thrombosis in an immunocompetent adolescent with acute cytomegalovirus hepatitis","volume":"28","author":"Ladd","year":"2009","journal-title":"J Thromb Thrombolysis"},{"key":"2021030519525700300_CIT0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-0500-7-193","article-title":"Myopericarditis complicated by pulmonary embolism in an immunocompetent patient with acute cytomegalovirus infection: a case report","volume":"7","author":"Vandamme","year":"2014","journal-title":"BMC Res Notes"},{"key":"2021030519525700300_CIT0031","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s40477-016-0227-0","article-title":"Case report: acute portal vein thrombosis associated with acute cytomegalovirus infection in an immunocompetent adult","volume":"20","author":"Puccia","year":"2017","journal-title":"J Ultrasound"},{"key":"2021030519525700300_CIT0032","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejim.2010.11.006","article-title":"Thrombosis associated with acute cytomegalovirus infection: a meta-analysis","volume":"22","author":"Justo","year":"2011","journal-title":"Eur J Intern Med"},{"key":"2021030519525700300_CIT0033","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/infdis\/jit064","article-title":"Cytomegalovirus exposure and cardiovascular disease in kidney transplant recipients","volume":"207","author":"Courivaud","year":"2013","journal-title":"J Infect Dis"},{"key":"2021030519525700300_CIT0034","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/00007890-199808150-00003","article-title":"Cytomegalovirus and its association with hepatic artery thrombosis after liver transplantation","volume":"66","author":"Madalosso","year":"1998","journal-title":"Transplantation"},{"key":"2021030519525700300_CIT0035","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/00007890-200007270-00013","article-title":"Increased incidence of cardiac complications in kidney transplant recipients with cytomegalovirus disease","volume":"70","author":"Humar","year":"2000","journal-title":"Transplantation"},{"key":"2021030519525700300_CIT0036","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/tri.13145","article-title":"Cytomegalovirus reactivation in liver transplant recipients due to hepatitis C cirrhosis is associated with higher cardiovascular risk - an observational, retrospective study","volume":"31","author":"Aguilera","year":"2018","journal-title":"Transpl Int"},{"key":"2021030519525700300_CIT0037","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.CIR.100.1.61","article-title":"Impact of prophylactic immediate posttransplant ganciclovir on development of transplant atherosclerosis: a post hoc analysis of a randomized, placebo-controlled study","volume":"100","author":"Valantine","year":"1999","journal-title":"Circulation"},{"key":"2021030519525700300_CIT0038","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/01.TP.0000140993.16332.18","article-title":"Venous thromboembolism in renal transplant recipients","volume":"79","author":"Mettu","year":"2005","journal-title":"Transplantation"},{"key":"2021030519525700300_CIT0039","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1160\/TH07-05-0340","article-title":"Possible contribution of cytomegalovirus infection to the high risk of (recurrent) venous thrombosis after renal transplantation","volume":"99","author":"Lijfering","year":"2008","journal-title":"Thromb Haemost"},{"key":"2021030519525700300_CIT0040","first-page":"87","article-title":"Definitions of cytomegalovirus infection and disease in transplant patients for use in clinical trials","volume":"64","author":"Ljungman","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2021030519525700300_CIT0041","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1086\/339329","article-title":"Definitions of cytomegalovirus infection and disease in transplant recipients","volume":"34","author":"Ljungman","year":"2002","journal-title":"Clin Infect Dis"},{"key":"2021030519525700300_CIT0042","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.eimc.2011.05.022","article-title":"GESITRA-SEIMC\/REIPI recommendations for the management of cytomegalovirus infection in solid-organ transplant patients","volume":"29","author":"de la Torre-Cisneros","year":"2011","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"2021030519525700300_CIT0043","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/ajh.22006","article-title":"Active cytomegalovirus infection in patients with acute venous thrombosis: a case-control study","volume":"86","author":"Tichelaar","year":"2011","journal-title":"Am J Hematol"},{"key":"2021030519525700300_CIT0044","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00277-011-1334-9","article-title":"Cytomegalovirus infection is associated with venous thromboembolism of immunocompetent adults--a case-control study","volume":"91","author":"Schimanski","year":"2012","journal-title":"Ann Hematol"},{"key":"2021030519525700300_CIT0045","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1016\/j.thromres.2010.09.006","article-title":"Incidence of cytomegalovirus-associated thrombosis and its risk factors: a case-control study","volume":"126","author":"Atzmony","year":"2010","journal-title":"Thromb Res"},{"key":"2021030519525700300_CIT0046","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.5114\/aoms.2014.47828","article-title":"Thrombosis associated with acute cytomegalovirus infection: a narrative review","volume":"10","author":"Sherman","year":"2014","journal-title":"Arch Med Sci"},{"key":"2021030519525700300_CIT0047","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1161\/01.ATV.17.9.1780","article-title":"Cytomegalovirus infection, lipoprotein(a), and hypercoagulability: an atherogenic link?","volume":"17","author":"Nieto","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021030519525700300_CIT0048","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10238-015-0376-z","article-title":"T cell senescence and cardiovascular diseases","volume":"16","author":"Yu","year":"2016","journal-title":"Clin Exp Med"},{"key":"2021030519525700300_CIT0049","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/cmi.2014.93","article-title":"Senescent cytotoxic T cells in acute myocardial infarction: innocent bystanders or the horsemen of apocalypse?","volume":"12","author":"Hoffmann","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"2021030519525700300_CIT0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11357-017-9984-8","article-title":"Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence","volume":"39","author":"Nikolich-\u017dugich","year":"2017","journal-title":"Geroscience"},{"key":"2021030519525700300_CIT0051","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1086\/528718","article-title":"Delayed-onset primary cytomegalovirus disease and the risk of allograft failure and mortality after kidney transplantation","volume":"46","author":"Arthurs","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2021030519525700300_CIT0052","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-017-2599-y","article-title":"Cytomegalovirus viraemia and mortality in renal transplant recipients in the era of antiviral prophylaxis. Lessons from the western Australian experience","volume":"17","author":"Selvey","year":"2017","journal-title":"BMC Infect Dis"},{"key":"2021030519525700300_CIT0053","doi-asserted-by":"crossref","first-page":"e005466","DOI":"10.1161\/JAHA.117.005466","article-title":"Long-term effects of unprovoked venous thromboembolism on mortality and major cardiovascular events","volume":"6","author":"Chang","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2021030519525700300_CIT0054","doi-asserted-by":"crossref","first-page":"e1001155","DOI":"10.1371\/journal.pmed.1001155","article-title":"Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors","volume":"9","author":"Flinterman","year":"2012","journal-title":"PLOS Med"},{"key":"2021030519525700300_CIT0055","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/CIRCULATIONAHA.114.009107","article-title":"30-year mortality after venous thromboembolism: a population-based cohort study","volume":"130","author":"S\u00f8gaard","year":"2014","journal-title":"Circulation"},{"key":"2021030519525700300_CIT0056","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.healun.2004.07.003","article-title":"Symptomatic acute myocardial infarction in a cardiac transplant recipient successfully treated with primary coronary angioplasty: evidence of prognostic importance of chest pain after cardiac transplantation","volume":"24","author":"Di Cori","year":"2005","journal-title":"J Heart Lung Transplant"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa125\/32972017\/ciaa125.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/72\/5\/845\/36415656\/ciaa125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/72\/5\/845\/36415656\/ciaa125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T20:00:46Z","timestamp":1614974446000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/72\/5\/845\/5728524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,6]]},"references-count":56,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,2,6]]},"published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa125","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2020,2,6]]}}}