{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:50:16Z","timestamp":1790844616243,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006387","name":"Leenaards Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lung ultrasonography (LUS) is a promising pragmatic risk-stratification tool in coronavirus disease 2019 (COVID-19). This study describes and compares LUS characteristics between patients with different clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study of polymerase chain reaction\u2013confirmed adults with COVID-19 with symptoms of lower respiratory tract infection in the emergency department (ED) of Lausanne University Hospital. A trained physician recorded LUS images using a standardized protocol. Two experts reviewed images blinded to patient outcome. We describe and compare early LUS findings (\u226424 hours of ED presentation) between patient groups based on their 7-day outcome (1) outpatients, (2) hospitalized, and (3) intubated\/dead. Normalized LUS score was used to discriminate between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 6 March and 3 April 2020, we included 80 patients (17 outpatients, 42 hospitalized, and 21 intubated\/dead). Seventy-three patients (91%) had abnormal LUS (70% outpatients, 95% hospitalized, and 100% intubated\/dead; P\u2005=\u2005.003). The proportion of involved zones was lower in outpatients compared with other groups (median [IQR], 30% [0\u201340%], 44% [31\u201370%], 70% [50\u201388%]; P\u2005&amp;lt;\u2005.001). Predominant abnormal patterns were bilateral and there was multifocal spread thickening of the pleura with pleural line irregularities (70%), confluent B lines (60%), and pathologic B lines (50%). Posterior inferior zones were more often affected. Median normalized LUS score had a good level of discrimination between outpatients and others with area under the ROC of .80 (95% CI, .68\u2013.92).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Systematic LUS has potential as a reliable, cheap, and easy-to-use triage tool for the early risk stratification in patients with COVID-19 presenting to EDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaa1408","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T15:17:04Z","timestamp":1600183024000},"page":"e4189-e4196","source":"Crossref","is-referenced-by-count":47,"title":["Lung Ultrasonography for Risk Stratification in Patients with Coronavirus Disease 2019 (COVID-19): A Prospective Observational Cohort Study"],"prefix":"10.1093","volume":"73","author":[{"given":"Thomas","family":"Brahier","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Meuwly","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pantet","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9e","family":"Brochu Vez","sequence":"additional","affiliation":[{"name":"Emergency Department, University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Gerhard Donnet","sequence":"additional","affiliation":[{"name":"Emergency Department, University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Anne","family":"Hartley","sequence":"additional","affiliation":[{"name":"Digital Global Health Department, Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland"},{"name":"Machine Learning and Optimization Laboratory, \u00c9cole polytechnique f\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hugli","sequence":"additional","affiliation":[{"name":"Emergency Department, University Hospital and University of Lausanne, Lausanne, 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