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We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.<\/jats:p>","DOI":"10.1093\/cid\/ciaa1474","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T19:18:44Z","timestamp":1600975124000},"page":"e1762-e1765","source":"Crossref","is-referenced-by-count":100,"title":["Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-9064","authenticated-orcid":false,"given":"Martin","family":"Martinot","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, H\u00f4pitaux Civils de Colmar, Colmar, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Jary","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, AP-HP, 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