{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:28:44Z","timestamp":1769117324563,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Prolonged QTc intervals and life-threatening arrhythmias (LTA) are potential drug-induced complications previously reported with antimalarials, antivirals, and antibiotics. Our objective was to evaluate the prevalence and predictors of QTc interval prolongation and incidences of LTA during hospitalization for coronavirus disease 2019 (COVID-19) among patients with normal admission QTc.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled 110 consecutive patients in a multicenter international registry. A 12-lead electrocardiograph was performed at admission, after 7, and at 14 days; QTc values were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After 7 days, 15 (14%) patients developed a prolonged QTc (pQTc; mean QTc increase 66 \u00b1 20 msec; +16%; P &amp;lt; .001); these patients were older and had higher basal heart rates, higher rates of paroxysmal atrial fibrillation, and lower platelet counts. The QTc increase was inversely proportional to the baseline QTc level and leukocyte count and directly proportional to the basal heart rate (P &amp;lt; .01).<\/jats:p>\n                  <jats:p>We conducted a multivariate stepwise analysis including age, male gender, paroxysmal atrial fibrillation, basal QTc values, basal heart rate, and dual antiviral therapy; age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.00\u20131.13; P &amp;lt; .05), basal heart rate (OR, 1.07; 95% CI, 1.02\u20131.13; P &amp;lt; .01), and dual antiviral therapy (OR, 12.46; 95% CI, 2.09\u201374.20; P &amp;lt; .1) were independent predictors of QT prolongation.<\/jats:p>\n                  <jats:p>The incidence rate of LTA during hospitalization was 3.6%. There was 1 patient who experienced cardiac arrest and 3 with nonsustained ventricular tachycardia. LTAs were recorded after a median of 9 days from hospitalization and were associated with 50% of the mortality rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>After 7 days of hospitalization, 14% of patients with COVID-19 developed pQTc; age, basal heart rate, and dual antiviral therapy were found to be independent predictors of pQTc. Life-threatening arrhythmias have an incidence rate of 3.6%, and were associated with a poor outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa1578","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T19:21:48Z","timestamp":1602703308000},"page":"e4031-e4038","source":"Crossref","is-referenced-by-count":25,"title":["QTc Interval Prolongation and Life-Threatening Arrhythmias During Hospitalization in Patients With Coronavirus Disease 2019 (COVID-19): Results From a Multicenter Prospective Registry"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-6513","authenticated-orcid":false,"given":"Francesco","family":"Santoro","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"},{"name":"Department of Cardiology, Bonomo Hospital, Andria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Monitillo","sequence":"additional","affiliation":[{"name":"Emergency Cardiology Unit, University Hospital of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Section of Anesthesia and Intensive Care, Department of Emergency and Organ Transplantation, \u201cAldo Moro\u201d University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostino","family":"Lopizzo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, San Carlo Hospital, Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Brindicci","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital-University Polyclinic of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Gilio","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, San Carlo Hospital, Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Musaico","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vittorio Emanuele II Hospital, Bisceglie, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Vittorio Emanuele II Hospital, Bisceglie, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Vestito","sequence":"additional","affiliation":[{"name":"Emergency Cardiology Unit, University Hospital of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella Di","family":"Benedetto","sequence":"additional","affiliation":[{"name":"Section of Anesthesia and Intensive Care, Department of Emergency and Organ Transplantation, \u201cAldo Moro\u201d University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Abumayyaleh","sequence":"additional","affiliation":[{"name":"University Mannheim, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"El-Battrawy","sequence":"additional","affiliation":[{"name":"University Mannheim, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Rita","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Disease, San Giuseppe Moscati Hospital, Taranto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi Flavio Massimiliano","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Santa Maria Degli Angeli Hospital, Putignano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[{"name":"University Mannheim, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital-University Polyclinic of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Fiorilli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, San Carlo Hospital, Potenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Cannone","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bonomo Hospital, Andria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Saracino","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital-University Polyclinic of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Angarano","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital-University Polyclinic of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Carbonara","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Vittorio Emanuele II Hospital, Bisceglie, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Grasso","sequence":"additional","affiliation":[{"name":"Section of Anesthesia and Intensive Care, Department of Emergency and Organ Transplantation, \u201cAldo Moro\u201d University of Bari, Bari, 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