{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:07:05Z","timestamp":1740128825655,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01443","PI19\/01312"],"award-info":[{"award-number":["PI16\/01443","PI19\/01312"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Network for AIDS Investigation"},{"name":"European Fund for Development of Regions"},{"DOI":"10.13039\/501100015756","name":"Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII","doi-asserted-by":"publisher","award":["CM19\/00251"],"award-info":[{"award-number":["CM19\/00251"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In the setting of hepatitis C virus (HCV) active infection, liver stiffness (LS)\u2013based strategies identify patients with low risk of developing esophageal variceal bleeding (VB) episodes, in whom unnecessary upper esophagogastroduodenoscopy (UGE) screening can be safely avoided. However, after sustained virological response (SVR), data on the accuracy of the criteria predicting this outcome in HCV-infected patients with cirrhosis, with or without human immunodeficiency virus (HIV) coinfection, are very limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a multicenter prospective cohort study, where HCV-monoinfected patients and HIV\/HCV-coinfected individuals were included if they had (1) SVR with direct-acting antiviral\u2013based therapy; (2) LS \u22659.5 kPa previous to treatment; and (3) LS measurement at the SVR time-point \u226514 kPa. Diagnostic accuracy of HEPAVIR, expanded Baveno VI, and HIV cirrhosis criteria, at the time of SVR, was evaluated. Missed VB episodes, negative predictive values (NPVs), and number of spared UGEs were specifically assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Four hundred thirty-five patients were included, 284 (65%) coinfected with HIV. Seven (1.6%) patients developed a first episode of VB after SVR. In patients without a previous VB episode, HEPAVIR, expanded Baveno VI and HIV cirrhosis criteria achieved NPV for first VB episode after SVR of 99.5% (95% confidence interval [CI], 97.1%\u2013100%), 100% (95% CI 97.8%\u2013100%), and 100% (95% CI 98%\u2013100%) while sparing 45%, 39%, and 44% of UGEs, respectively. When considering HIV coinfection, the performance of the 3 criteria was similar, both in HCV-monoinfected and HIV\/HCV-coinfected individuals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>After SVR, predictive LS-based strategies accurately identify HCV-infected patients, HIV coinfected or not, with low risk of developing VB during follow-up. In these specific patients, using HIV cirrhosis criteria maximize the number of spared UGEs while missing no VB episode.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa1726","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T20:12:30Z","timestamp":1605298350000},"page":"e96-e102","source":"Crossref","is-referenced-by-count":3,"title":["Liver Stiffness\u2013Based Strategies Predict Absence of Variceal Bleeding in Cirrhotic Hepatitis C Virus\u2013Infected Patients With and Without Human Immunodeficiency Virus Coinfection After Sustained Virological Response"],"prefix":"10.1093","volume":"72","author":[{"given":"Ana\u00efs","family":"Corma-G\u00f3mez","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"Unit of 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Jos\u00e9","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario Virgen Macarena, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Santos","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, University Hospital Jerez, Cadiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Serrano","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario de Gran Canaria Dr Negr\u00edn, Las Palmas de Gran Canaria, Las Palmas, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Palacios","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases and Microbiology, Hospital Virgen de la Victoria, M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Merino","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Juan Ram\u00f3n Jim\u00e9nez, Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Miguel","family":"Real","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Biochemistry, Molecular Biology and Surgery, Faculty of Medicine, University of Malaga, M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"De Los Santos","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Infectious Diseases, Hospital La Princesa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J","family":"Vera-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Section of Infectious Medicine\/Service of Internal Medicine, Hospital General Universitario Santa Luc\u00eda, 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