{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:37:33Z","timestamp":1790645853162,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cutibacterium species are common pathogens in periprosthetic joint infections (PJI). These infections are often treated with \u03b2-lactams or clindamycin as monotherapy, or in combination with rifampin. Clinical evidence supporting the value of adding rifampin for treatment of Cutibacterium PJI is lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this multicenter retrospective study, we evaluated patients with Cutibacterium PJI and a minimal follow-up of 12 months. The primary endpoint was clinical success, defined by the absence of infection relapse or new infection. We used Fisher\u2019s exact tests and Cox proportional hazards models to analyze the effect of rifampin and other factors on clinical success after PJI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 187 patients (72.2% male, median age 67 years) with a median follow-up of 36 months. The surgical intervention was a 2-stage exchange in 95 (50.8%), 1-stage exchange in 51 (27.3%), debridement and implant retention (DAIR) in 34 (18.2%), and explantation without reimplantation in 7 (3.7%) patients. Rifampin was included in the antibiotic regimen in 81 (43.3%) cases. Infection relapse occurred in 28 (15.0%), and new infection in 13 (7.0%) cases. In the time-to-event analysis, DAIR (adjusted hazard ratio [HR]\u2005=\u20052.15, P\u2005=\u2005.03) and antibiotic treatment over 6 weeks (adjusted HR\u2005=\u20050.29, P\u2005=\u2005.0002) significantly influenced treatment failure. We observed a tentative evidence for a beneficial effect of adding rifampin to the antibiotic treatment\u2014though not statistically significant for treatment failure (adjusted HR\u2005=\u20050.5, P\u2005=\u2005.07) and not for relapses (adjusted HR\u2005=\u20050.5, P\u2005=\u2005.10).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We conclude that a rifampin combination is not markedly superior in Cutibacterium PJI, but a dedicated prospective multicenter study is needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa1839","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T03:20:15Z","timestamp":1607397615000},"page":"e1064-e1073","source":"Crossref","is-referenced-by-count":43,"title":["The Impact of Surgical Strategy and Rifampin on Treatment Outcome in <i>Cutibacterium<\/i> Periprosthetic Joint Infections"],"prefix":"10.1093","volume":"72","author":[{"given":"Katharina","family":"Kusejko","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Au\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"IIS\u2014Fundacion Jimenez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Jost","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benito","family":"Natividad","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau, Departament of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Strahm","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Thurnheer","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pablo-Marcos","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marques de Valdecilla, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorsaf","family":"Slama","sequence":"additional","affiliation":[{"name":"Cochin Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Scanferla","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker","family":"Uckay","sequence":"additional","affiliation":[{"name":"University Hospital Zurich, Orthopedic University Hospital Balgrist, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Waldmann","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Esteban","sequence":"additional","affiliation":[{"name":"IIS\u2014Fundacion Jimenez Diaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Lora-Tamayo","sequence":"additional","affiliation":[{"name":"Hospital Univ. 12 de Octubre, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Clauss","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Infections, Department for Orthopedics and Trauma Surgery, University Hospital Basel, University of Basel, Basel, and Kantonsspital Baselland, Liestal, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Fernandez-Sampedro","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marques de Valdecilla, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Wouthuyzen-Bakker","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo Carlo","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center -IRCCS and Humanitas University, Department of Biomedical Sciences, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Gassmann","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parham","family":"Sendi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Jent","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe C","family":"Morand","sequence":"additional","affiliation":[{"name":"APHP.Centre -Universit\u00e9 de Paris, Cochin Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakhar","family":"Vijayvargiya","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihard","family":"Treb\u0161e","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Ljubljana, Valdoltra Orthopedic Hospital, Ankaran, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D","family":"Kouyos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"},{"name":"Institute of Medical Virology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Corvec","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie- Hygi\u00e8ne hospitali\u00e8re, CRCINA, Universit\u00e9 de Nantes, Centre Hospitalier Universitaire de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias Siegfried","family":"Kramer","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany; Evangelisches Waldkrankenhaus Spandau, Berlin, Germany LADR Zentrallabor Dr. Kramer und Kollegen, Geesthacht, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A","family":"Stadelmann","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Schulthess Clinic, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Achermann","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"2021090910255011300_CIT0001","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/CMR.00111-13","article-title":"Prosthetic joint infection","volume":"27","author":"Tande","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"2021090910255011300_CIT0002","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1128\/JCM.01435-16","article-title":"Optimal length of cultivation time for isolation of Propionibacterium acnes in suspected bone and joint infections is more than 7 days","volume":"54","author":"Bossard","year":"2016","journal-title":"J Clin Microbiol"},{"key":"2021090910255011300_CIT0003","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/cid\/cix665","article-title":"Propionibacterium avidum: a virulent pathogen causing hip periprosthetic joint infection","volume":"66","author":"Achermann","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2021090910255011300_CIT0004","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1016\/j.arth.2018.02.008","article-title":"Cutibacterium (formerly Propionibacterium) avidum: a rare but avid agent of prosthetic hip infection","volume":"33","author":"Zeller","year":"2018","journal-title":"J Arthroplasty"},{"key":"2021090910255011300_CIT0005","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1016\/j.rcot.2017.09.154","article-title":"Propionibacterium avidum, un agent rare d\u2019infection de proth\u00e8se articulaire de hanche","volume":"103","author":"Marmor","year":"2017","journal-title":"Rev Chir Orthop\u00e9dique Traumatol"},{"key":"2021090910255011300_CIT0006","doi-asserted-by":"crossref","first-page":"e0202639","DOI":"10.1371\/journal.pone.0202639","article-title":"Orthopedic implant-associated infections caused by Cutibacterium spp.\u2014a remaining diagnostic challenge","volume":"13","author":"Renz","year":"2018","journal-title":"PLoS One"},{"key":"2021090910255011300_CIT0007","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.mi.41.100187.002251","article-title":"Bacterial biofilms in nature and disease","volume":"41","author":"Costerton","year":"1987","journal-title":"Annu Rev Microbiol"},{"key":"2021090910255011300_CIT0008","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"key":"2021090910255011300_CIT0009","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1128\/AAC.00775-08","article-title":"Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection","volume":"53","author":"Baldoni","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"2021090910255011300_CIT0010","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1128\/AAC.00675-11","article-title":"Adjunctive rifampin is crucial to optimizing daptomycin efficacy against rabbit prosthetic joint infection due to methicillin-resistant Staphylococcus aureus","volume":"55","author":"Saleh-Mghir","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"2021090910255011300_CIT0011","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/cid\/cir402","article-title":"Outcome and predictors of treatment failure in total hip\/knee prosthetic joint infections due to Staphylococcus aureus","volume":"53","author":"Senneville","year":"2011","journal-title":"Clin Infect Dis"},{"key":"2021090910255011300_CIT0012","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/clinids\/14.6.1251","article-title":"Antimicrobial treatment of orthopedic implant-related infections with rifampin combinations","volume":"14","author":"Widmer","year":"1992","journal-title":"Clin Infect Dis"},{"key":"2021090910255011300_CIT0013","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/jac\/39.2.235","article-title":"Oral treatment of Staphylococcus spp. infected orthopaedic implants with fusidic acid or ofloxacin in combination with rifampicin","volume":"39","author":"Drancourt","year":"1997","journal-title":"J Antimicrob Chemother"},{"key":"2021090910255011300_CIT0014","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jinf.2011.07.001","article-title":"Efficacy of tigecycline alone and with rifampin in foreign-body infection by methicillin-resistant Staphylococcus aureus","volume":"63","author":"Garrig\u00f3s","year":"2011","journal-title":"J Infect"},{"key":"2021090910255011300_CIT0015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3109\/17453674.2015.1094613","article-title":"Treatment of prosthetic joint infections due to Propionibacterium. Similar results in 60 patients treated with and without rifampicin","volume":"87","author":"Jacobs","year":"2016","journal-title":"Acta Orthop"},{"key":"2021090910255011300_CIT0016","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jinf.2007.02.006","article-title":"Propionibacterium acnes: an agent of prosthetic joint infection and colonization","volume":"55","author":"Zeller","year":"2007","journal-title":"J Infect"},{"key":"2021090910255011300_CIT0017","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1086\/588477","article-title":"Propionibacterium acnes postoperative shoulder arthritis: an emerging clinical entity","volume":"46","author":"Levy","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2021090910255011300_CIT0018","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1128\/AAC.05552-11","article-title":"Role of rifampin against Propionibacterium acnes biofilm in vitro and in an experimental foreign-body infection model","volume":"56","author":"Furustrand Tafin","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2021090910255011300_CIT0019","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrika"},{"key":"2021090910255011300_CIT0020","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1056\/NEJMra040181","article-title":"Prosthetic-joint infections","volume":"351","author":"Zimmerli","year":"2004","journal-title":"N Engl J Med"},{"key":"2021090910255011300_CIT0021","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s15010-004-4020-1","article-title":"Management of infection associated with total hip arthroplasty according to a treatment algorithm","volume":"32","author":"Giulieri","year":"2004","journal-title":"Infection"},{"key":"2021090910255011300_CIT0022","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1469-0691.2006.01378.x","article-title":"Outcome of prosthetic knee-associated infection: evaluation of 40 consecutive episodes at a single centre","volume":"12","author":"Laffer","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"2021090910255011300_CIT0023","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2106\/00004623-199604000-00005","article-title":"Infection after total hip arthroplasty. A study of the treatment of one hundred and six infections","volume":"78","author":"Tsukayama","year":"1996","journal-title":"J Bone Joint Surg Am"},{"key":"2021090910255011300_CIT0024","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1086\/529436","article-title":"Treatment of joint prosthesis infection in accordance with current recommendations improves outcome","volume":"46","author":"Betsch","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2021090910255011300_CIT0025","doi-asserted-by":"crossref","first-page":"993.e7","DOI":"10.1016\/j.amjmed.2006.03.036","article-title":"Conservative treatment of staphylococcal prosthetic joint infections in elderly patients","volume":"119","author":"Barber\u00e1n","year":"2006","journal-title":"Am J Med"},{"key":"2021090910255011300_CIT0026","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1007\/s00167-015-3780-8","article-title":"One-stage versus two-stage exchange arthroplasty for infected total knee arthroplasty: a systematic review","volume":"24","author":"Nagra","year":"2016","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"2021090910255011300_CIT0027","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1186\/s12891-019-2848-x","article-title":"One- and two-stage surgical revision of infected elbow prostheses following total joint replacement: a systematic review","volume":"20","author":"Kunutsor","year":"2019","journal-title":"BMC Musculoskelet Disord"},{"key":"2021090910255011300_CIT0028","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.jse.2018.06.004","article-title":"One-stage exchange of septic shoulder arthroplasty following a standardized treatment algorithm","volume":"27","author":"Sevelda","year":"2018","journal-title":"J Shoulder Elbow Surg"},{"key":"2021090910255011300_CIT0029","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00264-015-2833-4","article-title":"One-stage revision of infected hip arthroplasty: outcome of 39 consecutive hips","volume":"40","author":"Ilchmann","year":"2016","journal-title":"Int Orthop"},{"key":"2021090910255011300_CIT0030","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s15010-012-0325-7","article-title":"Factors associated with rifampin resistance in staphylococcal periprosthetic joint infections (PJI): a matched case-control study","volume":"41","author":"Achermann","year":"2013","journal-title":"Infection"},{"key":"2021090910255011300_CIT0031","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7150\/jbji.30029","article-title":"Rifampin-resistant Cutibacterium (formerly Propionibacterium) namnetense superinfection after staphylococcus aureus bone infection treatment","volume":"3","author":"Corvec","year":"2018","journal-title":"J Bone Jt Infect"},{"key":"2021090910255011300_CIT0032","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.anaerobe.2015.05.003","article-title":"Occurrence and new mutations involved in rifampicin-resistant Propionibacterium acnes strains isolated from biofilm or device-related infections","volume":"34","author":"Furustrand Tafin","year":"2015","journal-title":"Anaerobe"},{"key":"2021090910255011300_CIT0033","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/jac\/dks428","article-title":"In vitro emergence of rifampicin resistance in Propionibacterium acnes and molecular characterization of mutations in the rpoB gene","volume":"68","author":"Furustrand Tafin","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"2021090910255011300_CIT0034","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.medmal.2014.02.004","article-title":"Propionibacterium acnes, an emerging pathogen: from acne to implant-infections, from phylotype to resistance","volume":"44","author":"Aubin","year":"2014","journal-title":"Med Mal Infect"},{"key":"2021090910255011300_CIT0035","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/cis803","article-title":"Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America","volume":"56","author":"Osmon","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2021090910255011300_CIT0036","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/cid\/cir842","article-title":"Systemic antibiotic therapy for chronic osteomyelitis in adults","volume":"54","author":"Spellberg","year":"2012","journal-title":"Clin Infect Dis"},{"key":"2021090910255011300_CIT0037","doi-asserted-by":"crossref","first-page":"108","DOI":"10.12688\/wellcomeopenres.15314.3","article-title":"Cost-effectiveness of oral versus intravenous antibiotics (OVIVA) in patients with bone and joint infection: evidence from a non-inferiority trial","volume":"4","author":"McMeekin","year":"2019","journal-title":"Wellcome Open Res"},{"key":"2021090910255011300_CIT0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta23380","article-title":"Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT","volume":"23","author":"Scarborough","year":"2019","journal-title":"Health Technol Assess"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa1839\/36644532\/ciaa1839.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/72\/12\/e1064\/40335094\/ciaa1839.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/72\/12\/e1064\/40335094\/ciaa1839.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T10:35:33Z","timestamp":1631183733000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/72\/12\/e1064\/6029420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,10]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,10]]},"published-print":{"date-parts":[[2021,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa1839","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,6,15]]},"published":{"date-parts":[[2020,12,10]]}}}