{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:54Z","timestamp":1787008614464,"version":"build-2736575974"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2 TR001426"],"award-info":[{"award-number":["KL2 TR001426"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23 HL123341"],"award-info":[{"award-number":["K23 HL123341"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UM1AI069501"],"award-info":[{"award-number":["UM1AI069501"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tuberculosis (TB) has been linked to an increased risk of atherosclerotic cardiovascular disease (ASCVD). We assessed whether latent TB infection (LTBI) is associated with subclinical coronary atherosclerosis in 2 TB-prevalent areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed cross-sectional data from studies conducted in Lima, Peru, and Kampala, Uganda. Individuals \u226540 years old were included. We excluded persons with known history of ASCVD events or active TB. Participants underwent QuantiFERON-TB (QFT) testing to define LTBI and computed tomography angiography to examine coronary atherosclerosis. A Coronary Artery Disease\u2013Reporting Data System (CAD-RADS) score \u22653 defined obstructive CAD (plaque causing \u226550% stenosis).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>113 and 91 persons with and without LTBI, respectively, were included. There were no significant differences between LTBI and non-LTBI participants in terms of age (median [interquartile range]; 56 [51\u201362] vs 55 [49\u201364] years; P\u2005=\u2005.829), male sex (38% vs 42%; P\u2005=\u2005.519), or 10-year ASCVD risk scores (7.1 [3.2\u201311.7] vs 6.1 [2.8\u20131.8]; P\u2005=\u2005.533). CAD prevalence (any plaque) was similar between groups (29% vs 24%; P\u2005=\u2005.421). Obstructive CAD was present in 9% of LTBI and 3% of non-LTBI individuals (P\u2005=\u2005.095). LTBI was associated with obstructive CAD after adjusting for ASCVD risk score, HIV status, and study site (adjusted OR, 4.96; 95% CI, 1.05\u201323.44; P\u2005=\u2005.043). Quantitative QFT TB antigen minus Nil interferon-\u03b3 responses were associated with obstructive CAD (adjusted OR, 1.2; 95% CI, 1.03\u20131.41; P\u2005=\u2005.022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LTBI was independently associated with an increased likelihood of subclinical obstructive CAD. Our data indicate that LTBI is a nontraditional correlate of ASCVD risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaa1934","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T15:16:00Z","timestamp":1609341360000},"page":"e3384-e3390","source":"Crossref","is-referenced-by-count":40,"title":["Latent Tuberculosis Infection and Subclinical Coronary Atherosclerosis in Peru and Uganda"],"prefix":"10.1093","volume":"73","author":[{"given":"Moises A","family":"Huaman","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo N","family":"De Cecco","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Imaging, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio S","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Ticona","sequence":"additional","affiliation":[{"name":"Hospital Nacional Dos de Mayo, Lima, Peru"},{"name":"Department of Internal Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cissy","family":"Kityo","sequence":"additional","affiliation":[{"name":"Joint Clinical Research Centre, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Ballena","sequence":"additional","affiliation":[{"name":"Hospital Nacional Dos de Mayo, Lima, 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