{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:12:22Z","timestamp":1790838742024,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["2020XGZX052"],"award-info":[{"award-number":["2020XGZX052"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to report the clinical characteristics of imported cases of coronavirus disease 2019 (COVID-19) in Jiangsu Province.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively investigated the clinical, imaging, and laboratory characteristics of confirmed cases of COVID-19 with World Health Organization interim guidance in 3 grade IIIA hospitals of Jiangsu from 22 January to 14 February 2020. Real-time RT-PCR was used to detect the new coronavirus in respiratory samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 80 patients infected with COVID-19, 41 were female, with a median age of 46.1 years. Except for 3 severe patients, the rest of the 77 patients exhibited mild or moderate symptoms. Nine patients were unconfirmed until a third nucleic acid test; 38 cases had a history of chronic diseases. The main clinical manifestations of the patients were fever and cough, which accounted for 63 (78.75%) and 51 (63.75%) cases, respectively. Only 3 patients (3.75%) showed liver dysfunction. Imaging examination showed that 55 patients (68.75%) showed abnormal density shadow and 25 cases (31.25%) had no abnormal density shadow in the parenchyma of both lungs. Currently, 21 cases have been discharged from the hospital, and no patient died. The average length of stay for discharged patients was 8 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with the cases in Wuhan, the cases in Jiangsu exhibited mild or moderate symptoms and no obvious gender susceptibility. The proportion of patients having liver dysfunction and abnormal CT imaging was relatively lower than that in Wuhan. Notably, infected patients may be falsely excluded based on 2 consecutively negative respiratory pathogenic nucleic acid test results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaa199","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T07:16:37Z","timestamp":1582701397000},"page":"706-712","source":"Crossref","is-referenced-by-count":404,"title":["Clinical Characteristics of Imported Cases of Coronavirus Disease 2019 (COVID-19) in Jiangsu Province: A Multicenter Descriptive Study"],"prefix":"10.1093","volume":"71","author":[{"given":"Jian","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Department of Laboratory Medicine, The First People\u2019s Hospital of Yancheng City, Yancheng, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Fifth People\u2019s Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Respiration, The Fifth People\u2019s Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First People\u2019s Hospital of Yancheng City, Yancheng, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First People\u2019s Hospital of Yancheng City, Yancheng, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The Second People\u2019s Hospital of Yancheng City, Yancheng, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second People\u2019s Hospital of Yancheng City, Yancheng, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Central Blood Station of Yancheng City, Yancheng, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-6867","authenticated-orcid":false,"given":"Hongcui","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physicochemical Injury Diseases, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,29]]},"reference":[{"key":"2020072806273040400_CIT0001","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","author":"Peng","year":"2020","journal-title":"Nature"},{"key":"2020072806273040400_CIT0002","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ijid.2020.01.050","article-title":"Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak","volume":"92","author":"Zhao","year":"2020","journal-title":"Int J Infect Dis"},{"key":"2020072806273040400_CIT0003","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9020498","article-title":"Novel coronavirus outbreak in Wuhan, China, 2020: intense surveillance is vital for preventing sustained transmission in new locations","volume":"9","author":"Thompson","year":"2020","journal-title":"J Clin Med"},{"key":"2020072806273040400_CIT0004","article-title":"The reproductive number of COVID-19 is higher compared to SARS coronavirus","author":"Liu","year":"2020","journal-title":"J Travel Med"},{"key":"2020072806273040400_CIT0005","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1016\/S1473-3099(18)30127-0","article-title":"Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission","volume":"18","author":"Hui","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2020072806273040400_CIT0006","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0140-6736(16)30623-7","article-title":"MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study","volume":"388","author":"Cho","year":"2016","journal-title":"Lancet"},{"key":"2020072806273040400_CIT0007","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/22221751.2020.1725399","article-title":"RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak","volume":"9","author":"Chen","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"2020072806273040400_CIT0008","doi-asserted-by":"crossref","DOI":"10.3201\/eid2605.200146","article-title":"Risk for transportation of 2019 novel coronavirus disease from Wuhan to other cities in China","volume":"26","author":"Du","year":"2020","journal-title":"Emerging Infect Dis"},{"key":"2020072806273040400_CIT0009","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"2020072806273040400_CIT0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jmv.25695","article-title":"Updates on Wuhan 2019 novel coronavirus epidemic","volume":"92","author":"Kofi Ayittey","year":"2020","journal-title":"J Med Virol"},{"key":"2020072806273040400_CIT0011","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.2020200241","article-title":"Chest CT findings in 2019 novel coronavirus (2019-nCoV) infections from Wuhan, China: key points for the radiologist","author":"Kanne","year":"2020","journal-title":"Radiology"},{"key":"2020072806273040400_CIT0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2020.01.003","article-title":"Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan. China","author":"Yu","year":"2020","journal-title":"Microbes Infect"},{"key":"2020072806273040400_CIT0013","article-title":"Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern","volume":"25","author":"Eurosurveillance Editorial Team","year":"2020","journal-title":"Euro Surveill"},{"key":"2020072806273040400_CIT0014","author":"World Health Organization","year":"2020"},{"key":"2020072806273040400_CIT0015","first-page":"E004","article-title":"Pulmonary rehabilitation guidelines in the principle of 4S for patients infected with 2019 novel coronavirus (2019-nCoV)","volume":"43","author":"Yang","year":"2020","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"2020072806273040400_CIT0016","doi-asserted-by":"crossref","DOI":"10.1007\/s12519-020-00345-5","article-title":"Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus","author":"Chen","year":"2020","journal-title":"World J Pediatr"},{"key":"2020072806273040400_CIT0017","doi-asserted-by":"crossref","DOI":"10.7326\/M20-0358","article-title":"Reporting, epidemic growth, and reproduction numbers for the 2019 novel coronavirus (2019-nCoV) epidemic","author":"Tuite","year":"2020","journal-title":"Ann. Intern. Med"},{"key":"2020072806273040400_CIT0018","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"2020072806273040400_CIT0019","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"2020072806273040400_CIT0020","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.2020200274","article-title":"Emerging coronavirus 2019-nCoV pneumonia","author":"Song","year":"2020","journal-title":"Radiology"},{"key":"2020072806273040400_CIT0021","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00127-20","article-title":"Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS","author":"Wan","year":"2020","journal-title":"J. Virol"},{"key":"2020072806273040400_CIT0022","article-title":"Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection","author":"Chai","year":"2020","journal-title":"bioRxiv"},{"key":"2020072806273040400_CIT0023","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.2020200230","article-title":"CT imaging features of 2019 novel coronavirus (2019-nCoV)","author":"Chung","year":"2020","journal-title":"Radiology"},{"key":"2020072806273040400_CIT0024","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/cbic.202000047","article-title":"Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV","volume":"21","author":"Liu","year":"2020","journal-title":"Chembiochem"},{"key":"2020072806273040400_CIT0025","doi-asserted-by":"crossref","DOI":"10.5582\/bst.2020.01020","article-title":"Drug treatment options for the 2019-new coronavirus (2019-nCoV)","author":"Lu","year":"2020","journal-title":"Biosci Trends"},{"key":"2020072806273040400_CIT0026","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMoa2001191","article-title":"First case of 2019 novel coronavirus in the United States","volume":"382","author":"Holshue","year":"2020","journal-title":"N Engl J Med"},{"key":"2020072806273040400_CIT0027","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","article-title":"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa199\/32992982\/ciaa199.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/15\/706\/33538097\/ciaa199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/15\/706\/33538097\/ciaa199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T06:29:04Z","timestamp":1595917744000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/71\/15\/706\/5766408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,29]]},"references-count":27,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2020,2,29]]},"published-print":{"date-parts":[[2020,7,28]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa199","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8,1]]},"published":{"date-parts":[[2020,2,29]]}}}