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Doxycycline prophylactic regimens have been shown to significantly reduce the risk for developing all of these infections in potentially exposed individuals, which is highly clinically relevant as no vaccines to prevent these infections in humans are currently available. Additional data, however, are needed to define more precisely the level of efficacy of the doxycycline prophylactic regimens, especially for Lyme disease and syphilis, infections that can be potentially prevented by a single 200-mg dose of doxycycline given within 72 hours postexposure.<\/jats:p>","DOI":"10.1093\/cid\/ciaa240","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T12:24:36Z","timestamp":1583497476000},"page":"2014-2017","source":"Crossref","is-referenced-by-count":13,"title":["Doxycycline for Prevention of Spirochetal Infections: Status Report"],"prefix":"10.1093","volume":"71","author":[{"given":"Gary P","family":"Wormser","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"2020110510421697600_CIT0001","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1056\/NEJM200107123450201","article-title":"Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite","volume":"345","author":"Nadelman","year":"2001","journal-title":"N Engl J Med"},{"key":"2020110510421697600_CIT0002","volume-title":"Modern epidemiology","author":"Rothman","year":"1986"},{"key":"2020110510421697600_CIT0003","volume-title":"Biostatistical methods in epidemiology","author":"Newman","year":"2001"},{"key":"2020110510421697600_CIT0004","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/jac\/dkq097","article-title":"Efficacy of antibiotic prophylaxis for the prevention of Lyme disease: an updated systematic review and meta-analysis","volume":"65","author":"Warshafsky","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"2020110510421697600_CIT0005","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/508667","article-title":"The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"43","author":"Wormser","year":"2006","journal-title":"Clin Infect Dis"},{"key":"2020110510421697600_CIT0006","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/cid\/ciy221","article-title":"Assessment of duration of tick feeding by the scutal index reduces need for antibiotic prophylaxis after Ixodes scapularis tick bites","volume":"67","author":"Falco","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2020110510421697600_CIT0007","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1086\/514009","article-title":"Duration of tick attachment as a predictor of the risk of Lyme disease in an area in which Lyme disease is endemic","volume":"175","author":"Sood","year":"1997","journal-title":"J Infect Dis"},{"key":"2020110510421697600_CIT0008","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/cid\/ciy222","article-title":"Scutal index and its role in guiding prophylaxis for Lyme disease following tick bite","volume":"67","author":"Pritt","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2020110510421697600_CIT0009","first-page":"1","article-title":"Surveillance for Lyme disease\u2014United States, 1992-2006","volume":"57","author":"Bacon","year":"2008","journal-title":"MMWR Surveill Summ"},{"key":"2020110510421697600_CIT0010","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1001\/jama.2018.17207","article-title":"Controversies about Lyme disease\u2014reply","volume":"320","author":"Shapiro","year":"2018","journal-title":"JAMA"},{"key":"2020110510421697600_CIT0011","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1056\/NEJM199610243351703","article-title":"Lyme disease in children in Southeastern Connecticut. 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