{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:51:35Z","timestamp":1790833895063,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We reviewed relevant syphilis diagnostic literature to address the question \u201cWhat diagnostic considerations should be taken into account when screening for syphilis using the traditional or reverse algorithm?\u201d Improved laboratory diagnosis of syphilis is an important element of the effort to reduce syphilis rates. Screening for syphilis is performed using either a nontreponemal or treponemal test (part of the traditional or reverse algorithm, respectively). Both syphilis algorithms are used by laboratories. However, there are limited data on the performance and cost-effectiveness of the algorithms. An expert panel generated \u201ckey questions\u201d in the laboratory diagnosis of syphilis. This paper pertains to the key factors that should be considered when deciding whether to screen for syphilis using either the traditional or the reverse algorithm. A systematic literature review was performed, and tables of evidence were created to address this question.<\/jats:p>","DOI":"10.1093\/cid\/ciaa307","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T16:13:54Z","timestamp":1585239234000},"page":"S43-S51","source":"Crossref","is-referenced-by-count":82,"title":["The Traditional or Reverse Algorithm for Diagnosis of Syphilis: Pros and Cons"],"prefix":"10.1093","volume":"71","author":[{"given":"Daniel A","family":"Ortiz","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur R","family":"Shukla","sequence":"first","affiliation":[{"name":"Division of STD Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Loeffelholz","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"2020062404343087300_CIT0001","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5858\/2016-0110-CP","article-title":"Prevalence of traditional and reverse-algorithm syphilis screening in laboratory practice: a survey of participants in the College of American Pathologists Syphilis Serology Proficiency Testing Program","volume":"141","author":"Rhoads","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"2020062404343087300_CIT0002","first-page":"872","article-title":"Syphilis testing algorithms using treponemal tests for initial screening\u2014four laboratories, New York City, 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