{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:19:28Z","timestamp":1778901568266,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["Z01-AI001063"],"award-info":[{"award-number":["Z01-AI001063"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1184344"],"award-info":[{"award-number":["OPP1184344"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["MR\/R015600\/1"],"award-info":[{"award-number":["MR\/R015600\/1"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UK Department for International Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Ivermectin-based onchocerciasis elimination, reported in 2009\u20132012, for Bakoye and Fal\u00e9m\u00e9, Mali, supported policy-shifting from morbidity control to elimination of transmission (EOT). These foci are coendemic with lymphatic filariasis (LF). In 2007\u20132016 mass ivermectin plus albendazole administration was implemented. We report Ov16 (onchocerciasis) and Wb123 (LF) seroprevalence after 24\u201325 years of treatment to determine if onchocerciasis EOT and LF elimination as a public health problem (EPHP) have been achieved.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The SD Bioline Onchocerciasis\/LF Ig[immunoglobulin]G4 biplex rapid diagnostic test (RDT) was used in 2186 children aged 3\u201310 years in 13 villages (plus 2 hamlets) in Bakoye and in 2270 children in 15 villages (plus 1 hamlet) in Fal\u00e9m\u00e9. In Bakoye, all-age serosurveys were conducted in 3 historically hyperendemic villages (1867 individuals aged 3 -78 years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In Bakoye, IgG4 seropositivity was 0.27% (95% confidence interval [CI] = .13%\u2013.60%) for both Ov16 and Wb123 antigens. In Fal\u00e9m\u00e9, Ov16 and Wb123 seroprevalence was 0.04% (95% CI = .01%\u2013.25%) and 0.09% (95% CI = .02%\u2013.32%), respectively. Ov16-seropositive children were from historically meso\/hyperendemic villages. Ov16 positivity was &amp;lt;2% in \u226414 year-olds, and 16% in \u226540 year-olds. Wb123 seropositivity was &amp;lt;2% in \u226439 year-olds, reaching 3% in \u226540 year-olds.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Notwithstanding uncertainty in the biplex RDT sensitivity, Ov16 and Wb123 seroprevalence among children in Bakoye and Fal\u00e9m\u00e9 is consistent with EOT (onchocerciasis) and EPHP (LF) since stopping treatment in 2016. The few Ov16-seropositive children should be skin-snip polymerase chain reaction tested and followed up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa318","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T20:12:01Z","timestamp":1584648721000},"page":"1585-1593","source":"Crossref","is-referenced-by-count":6,"title":["Serological Evaluation of Onchocerciasis and Lymphatic Filariasis Elimination in the Bakoye and Fal\u00e9m\u00e9 Foci, Mali"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4234-3488","authenticated-orcid":false,"given":"Housseini","family":"Dolo","sequence":"first","affiliation":[{"name":"Lymphatic Filariasis Research Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali"},{"name":"Global Health Institute, University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaya I","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Lymphatic Filariasis Research Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali"},{"name":"Centre National d\u2019Appui \u00e0 la lutte contre la Maladie, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moussa","family":"Sow","sequence":"additional","affiliation":[{"name":"Programme National de Lutte contre l\u2019Onchocercose, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massitan","family":"Demb\u00e9l\u00e9","sequence":"additional","affiliation":[{"name":"Programme National d\u2019Elimination de la Filariose Lymphatique, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salif S","family":"Doumbia","sequence":"additional","affiliation":[{"name":"Lymphatic Filariasis Research Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siaka Y","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Lymphatic Filariasis Research Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moussa B","family":"Sangare","sequence":"additional","affiliation":[{"name":"Lymphatic Filariasis Research Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilo","family":"Dicko","sequence":"additional","affiliation":[{"name":"Lymphatic Filariasis Research Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah A","family":"Diallo","sequence":"additional","affiliation":[{"name":"Lymphatic Filariasis Research Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamine","family":"Soumaoro","sequence":"additional","affiliation":[{"name":"Lymphatic Filariasis Research Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel E","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Lymphatic Filariasis Research Unit, International Center of Excellence in Research, Faculty of Medicine and Odontostomatology, Point G, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dansine","family":"Diarra","sequence":"additional","affiliation":[{"name":"Faculty of Geography and History, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-1340","authenticated-orcid":false,"given":"Robert","family":"Colebunders","sequence":"additional","affiliation":[{"name":"Global Health Institute, University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B","family":"Nutman","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Sciences and London Centre for Neglected Tropical Disease Research, Royal Veterinary College, Hatfield, United 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