{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:22:42Z","timestamp":1792664562184,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 AI136725"],"award-info":[{"award-number":["K01 AI136725"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AI007384"],"award-info":[{"award-number":["T32 AI007384"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AI028697"],"award-info":[{"award-number":["P30 AI028697"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 MH058107"],"award-info":[{"award-number":["P30 MH058107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We reviewed relevant syphilis diagnostic literature and conducted a meta-analysis to address the question, \u201cWhat is the sensitivity and specificity of the Syphilis Health Check, a rapid qualitative test for the detection of human antibodies to Treponema pallidum.\u201d The Syphilis Health Check is the only rapid syphilis test currently cleared by the Food and Drug Administration (FDA). We conducted a systematic review and a meta-analysis using Bayesian bivariate random-effects and fixed-effect models to create pooled estimates of sensitivity and specificity of the Syphilis Health Check. We identified 5 test evaluations published in the literature and 10 studies submitted to the FDA and for a Clinical Laboratory Improvement Amendments waiver application. The pooled sensitivity (95% CI) from the laboratory evaluations (n\u2005=\u20055) was 98.5% (92.1\u2013100%), while pooled specificity was 95.9% (81.5\u2013100.0%). The pooled sensitivity for prospective studies (n\u2005=\u200510) was 87.7% ( 71.8\u201397.2%), while pooled specificity was 96.7% (91.9\u201399.2%). Using nontreponemal supplemental testing, the sensitivity improved to a pooled sensitivity of 97.0% (94.8\u201398.6%). The Syphilis Health Check may provide accurate detection of treponemal antibody.<\/jats:p>","DOI":"10.1093\/cid\/ciaa350","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T15:14:19Z","timestamp":1586877259000},"page":"S52-S57","source":"Crossref","is-referenced-by-count":36,"title":["Clinical Test Performance of a Rapid Point-of-Care Syphilis Treponemal Antibody Test: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"71","author":[{"given":"Claire C","family":"Bristow","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, University of California, San Diego, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D","family":"Klausner","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Tran","sequence":"first","affiliation":[{"name":"District of Columbia Department of Forensic Sciences, Public Health Laboratory Division, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"2020062404340940900_CIT0001","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S1473-3099(09)70021-0","article-title":"Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies","volume":"9","author":"Boily","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"2020062404340940900_CIT0002","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1097\/QAI.0b013e3181a2671d","article-title":"High HIV and ulcerative sexually transmitted infection incidence estimates among men who have sex with men in Peru: awaiting for an effective preventive intervention","volume":"51","author":"Sanchez","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2020062404340940900_CIT0003","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1086\/315209","article-title":"Virulent Treponema pallidum, lipoprotein, and synthetic lipopeptides induce CCR5 on human monocytes and enhance their susceptibility to infection by human immunodeficiency virus type 1","volume":"181","author":"Sellati","year":"2000","journal-title":"J Infect Dis"},{"key":"2020062404340940900_CIT0004","author":"Centers for Disease Control and Prevention","year":"2017"},{"key":"2020062404340940900_CIT0005","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2015","volume":"64","author":"Workowski","year":"2015","journal-title":"MMWR Recomm Rep"},{"key":"2020062404340940900_CIT0006","doi-asserted-by":"crossref","first-page":"e1001396","DOI":"10.1371\/journal.pmed.1001396","article-title":"Global estimates of 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