{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:21:32Z","timestamp":1775910092007,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T00:00:00Z","timestamp":1586563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,15]]},"DOI":"10.1093\/cid\/ciaa425","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T19:14:05Z","timestamp":1586546045000},"page":"192-194","source":"Crossref","is-referenced-by-count":6,"title":["The Clofazimine for Treatment of Cryptosporidiosis in HIV-Infected Adults (CRYPTOFAZ) and Lessons Learned for Anticryptosporidial Drug Development"],"prefix":"10.1093","volume":"73","author":[{"given":"Christopher D","family":"Huston","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont, USA"},{"name":"Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, Burlington, Vermont, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,11]]},"reference":[{"key":"2021090910165745200_CIT0001","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1473-3099(14)70772-8","article-title":"A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for Cryptosporidium","volume":"15","author":"Checkley","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"2021090910165745200_CIT0002","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"2021090910165745200_CIT0003","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0140-6736(16)31529-X","article-title":"Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet"},{"key":"2021090910165745200_CIT0004","doi-asserted-by":"crossref","first-page":"e564","DOI":"10.1016\/S2214-109X(15)00151-5","article-title":"Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)","volume":"3","author":"Platts-Mills","year":"2015","journal-title":"Lancet Glob Health"},{"key":"2021090910165745200_CIT0005","first-page":"1660","article-title":"Epidemiology and risk factors for cryptosporidiosis in children from 8 low-income sites: results from the MAL-ED Study","volume":"67","author":"Korpe","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2021090910165745200_CIT0006","first-page":"CD004932","article-title":"Prevention and treatment of cryptosporidiosis in immunocompromised patients","volume":"1","author":"Abubakar","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"2021090910165745200_CIT0007","doi-asserted-by":"crossref","first-page":"e0003987","DOI":"10.1371\/journal.pntd.0003987","article-title":"A Proposed target product profile and developmental cascade for new cryptosporidiosis treatments","volume":"9","author":"Huston","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"2021090910165745200_CIT0008","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1021\/acsinfecdis.6b00094","article-title":"Cryptosporidiosis drug discovery: opportunities and challenges","volume":"2","author":"Manjunatha","year":"2016","journal-title":"ACS Infect Dis"},{"key":"2021090910165745200_CIT0009","first-page":"XXX","article-title":"Clofazimine for treatment of cryptosporidiosis in HIV-infected adults (CRYPTOFAZ): an experimental medicine, randomized, double-blind, placebo-controlled phase 2a trial","volume":"XX","author":"Iroh Tam","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2021090910165745200_CIT0010","doi-asserted-by":"crossref","first-page":"e0005373","DOI":"10.1371\/journal.pntd.0005373","article-title":"A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis","volume":"11","author":"Love","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"2021090910165745200_CIT0011","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1016\/S1473-3099(18)30177-4","article-title":"Experimental infection of human volunteers","volume":"18","author":"Roestenberg","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2021090910165745200_CIT0012","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1056\/NEJM199503303321304","article-title":"The infectivity of Cryptosporidium parvum in healthy volunteers","volume":"332","author":"DuPont","year":"1995","journal-title":"N Engl J Med"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa425\/33640793\/ciaa425.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/73\/2\/192\/40332987\/ciaa425.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/73\/2\/192\/40332987\/ciaa425.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T10:24:02Z","timestamp":1631183042000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/73\/2\/192\/5819179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,11]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,4,11]]},"published-print":{"date-parts":[[2021,7,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa425","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7,15]]},"published":{"date-parts":[[2020,4,11]]}}}