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The experiences presented are based on 2 large-scale COI studies embedded within the Surveillance for Enteric Fever in Asia Project II (SEAP II), in Bangladesh, Nepal, and Pakistan; and the Severe Typhoid Fever Surveillance in Africa (SETA) Program in Burkina Faso, Ethiopia, Ghana, and Madagascar. Issues presented include study design choices such as controlling for background patient morbidity and healthcare costs, time points for follow-up, data collection methods for sensitive income and spending information, estimating enteric fever\u2013specific health facility cost information, and analytic approaches in combining patient and health facility costs. The article highlights the potential tradeoffs in time, budget, and precision of results to assist those commissioning, conducting, and interpreting enteric fever COI studies.<\/jats:p>","DOI":"10.1093\/cid\/ciaa481","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T19:10:56Z","timestamp":1587582656000},"page":"S111-S119","source":"Crossref","is-referenced-by-count":10,"title":["Methodological Considerations for Cost of Illness Studies of Enteric Fever"],"prefix":"10.1093","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-9298","authenticated-orcid":false,"given":"Nelly","family":"Mejia","sequence":"first","affiliation":[{"name":"Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enusa","family":"Ramani","sequence":"additional","affiliation":[{"name":"Policy and Economic Research Department, Public Health, Access and 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