{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:58:44Z","timestamp":1790337524257,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation","doi-asserted-by":"publisher","award":["W81XWH-18-2-0040"],"award-info":[{"award-number":["W81XWH-18-2-0040"]}],"id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Thai Red Cross AIDS Research Center","award":["RV254\/SEARCH 010"],"award-info":[{"award-number":["RV254\/SEARCH 010"]}]},{"name":"Thai Government Pharmaceutical Organization"},{"DOI":"10.13039\/100008799","name":"Gilead Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Establishment of persistent human immunodeficiency virus type 1 (HIV-1) reservoirs occurs early in infection, and biomarkers of infected CD4+ T cells during acute infection are poorly defined. CD4+ T cells expressing the gut homing integrin complex \u03b14\u03b27 are associated with HIV-1 acquisition, and are rapidly depleted from the periphery and gastrointestinal mucosa during acute HIV-1 infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Integrated HIV-1 DNA was quantified in peripheral blood mononuclear cells obtained from acutely (Fiebig I\u2013III) and chronically infected individuals by sorting memory CD4+ T-cell subsets lacking or expressing high levels of integrin \u03b27 (\u03b27negative and \u03b27high, respectively). HIV-1 DNA was also assessed after 8 months of combination antiretroviral therapy (cART) initiated in Fiebig II\/III individuals. Activation marker and chemokine receptor expression was determined for \u03b27-defined subsets at acute infection and in uninfected controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Fiebig I, memory CD4+ T cells harboring integrated HIV-1 DNA were rare in both \u03b27high and \u03b27negative subsets, with no significant difference in HIV-1 DNA copies. In Fiebig stages II\/III and in chronically infected individuals, \u03b27high cells were enriched in integrated and total HIV-1 DNA compared to \u03b27negative cells. During suppressive cART, integrated HIV-1 DNA copies decreased in both \u03b27negative and \u03b27high subsets, which did not differ in DNA copies. In Fiebig II\/III, integrated HIV-1 DNA in \u03b27high cells was correlated with their activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\u03b27high memory CD4+ T cells are preferential targets during early HIV-1 infection, which may be due to the increased activation of these cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciaa497","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T23:39:50Z","timestamp":1587771590000},"page":"e735-e743","source":"Crossref","is-referenced-by-count":26,"title":["Preferential Infection of \u03b14\u03b27+ Memory CD4+ T Cells During Early Acute Human Immunodeficiency Virus Type 1 Infection"],"prefix":"10.1093","volume":"71","author":[{"given":"Andrey","family":"Tokarev","sequence":"first","affiliation":[{"name":"US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle R","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Centre for the AIDS Programme of Research in South Africa, Durban, South Africa"},{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Pagliuzza","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al and Department of Microbiology, Infectiology and Immunology, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Sivro","sequence":"additional","affiliation":[{"name":"Centre for the AIDS Programme of Research in South Africa, Durban, South Africa"},{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tosin E","family":"Omole","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Kroon","sequence":"additional","affiliation":[{"name":"South East Asia Research Collaboration in HIV, Thai Red Cross AIDS Research Centre, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitiya","family":"Chomchey","sequence":"additional","affiliation":[{"name":"South East Asia Research Collaboration in HIV, Thai Red Cross AIDS Research Centre, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0036-3165","authenticated-orcid":false,"given":"Nittaya","family":"Phanuphak","sequence":"additional","affiliation":[{"name":"South East Asia Research Collaboration in HIV, Thai Red Cross AIDS Research Centre, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Schuetz","sequence":"additional","affiliation":[{"name":"US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"},{"name":"Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merlin L","family":"Robb","sequence":"additional","affiliation":[{"name":"US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Eller","sequence":"additional","affiliation":[{"name":"US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintanat","family":"Ananworanich","sequence":"additional","affiliation":[{"name":"US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Chomont","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al and Department of Microbiology, Infectiology and Immunology, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane L","family":"Bolton","sequence":"additional","affiliation":[{"name":"US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"2021010207405031800_CIT0001","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/COH.0b013e3283504941","article-title":"Quality and quantity: mucosal CD4+ T cells and HIV susceptibility","volume":"7","author":"McKinnon","year":"2012","journal-title":"Curr Opin HIV AIDS"},{"key":"2021010207405031800_CIT0002","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1126\/science.286.5443.1353","article-title":"Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells","volume":"286","author":"Zhang","year":"1999","journal-title":"Science"},{"key":"2021010207405031800_CIT0003","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/mi.2014.26","article-title":"Phenotype and susceptibility to HIV infection of CD4+ Th17 cells in the human female reproductive tract","volume":"7","author":"Rodriguez-Garcia","year":"2014","journal-title":"Mucosal Immunol"},{"key":"2021010207405031800_CIT0004","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1086\/651021","article-title":"Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection","volume":"201","author":"El Hed","year":"2010","journal-title":"J Infect Dis"},{"key":"2021010207405031800_CIT0005","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/QAI.0000000000000389","article-title":"Early HIV-1 infection is associated with reduced frequencies of cervical Th17 cells","volume":"68","author":"McKinnon","year":"2015","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2021010207405031800_CIT0006","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1084\/jem.20121932","article-title":"Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production","volume":"210","author":"Perreau","year":"2013","journal-title":"J Exp Med"},{"key":"2021010207405031800_CIT0007","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1084\/jem.20100090","article-title":"Preferential infection and depletion of Mycobacterium tuberculosis\u2013specific CD4 T cells after HIV-1 infection","volume":"207","author":"Geldmacher","year":"2010","journal-title":"J Exp Med"},{"key":"2021010207405031800_CIT0008","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/417095a","article-title":"HIV preferentially infects HIV-specific CD4+ T cells","volume":"417","author":"Douek","year":"2002","journal-title":"Nature"},{"key":"2021010207405031800_CIT0009","doi-asserted-by":"crossref","first-page":"eaam6354","DOI":"10.1126\/scitranslmed.aam6354","article-title":"Integrin alpha4beta7 expression on peripheral blood CD4(+) T cells predicts HIV acquisition and disease progression outcomes","volume":"10","author":"Sivro","year":"2018","journal-title":"Sci Transl Med"},{"key":"2021010207405031800_CIT0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1600-0684.2009.00372.x","article-title":"CD4 T cell subsets in the mucosa are CD28+Ki-67\u2013HLA-DR-CD69+ but show differential infection based on alpha4beta7 receptor expression during acute SIV infection","volume":"38(Suppl 1)","author":"Kader","year":"2009","journal-title":"J Med Primatol"},{"key":"2021010207405031800_CIT0011","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/mi.2009.90","article-title":"Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection","volume":"2","author":"Kader","year":"2009","journal-title":"Mucosal Immunol"},{"key":"2021010207405031800_CIT0012","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11904-018-0382-3","article-title":"The role of integrin \u03b14\u03b27 in HIV pathogenesis and treatment","volume":"15","author":"Arthos","year":"2018","journal-title":"Curr HIV\/AIDS Rep"},{"key":"2021010207405031800_CIT0013","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/cid\/ciw365","article-title":"Initiation of antiretroviral therapy during acute HIV-1 infection leads to a high rate of nonreactive HIV serology","volume":"63","author":"de Souza","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2021010207405031800_CIT0014","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1097\/00002030-200309050-00005","article-title":"Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection","volume":"17","author":"Fiebig","year":"2003","journal-title":"AIDS"},{"key":"2021010207405031800_CIT0015","doi-asserted-by":"crossref","first-page":"12385","DOI":"10.1128\/JVI.00609-14","article-title":"Cross-clade ultrasensitive PCR-based assays to measure HIV persistence in large-cohort studies","volume":"88","author":"Vandergeeten","year":"2014","journal-title":"J Virol"},{"key":"2021010207405031800_CIT0016","doi-asserted-by":"crossref","first-page":"e1006445","DOI":"10.1371\/journal.ppat.1006445","article-title":"Combined single-cell quantitation of host and SIV genes and proteins ex vivo reveals host-pathogen interactions in individual cells","volume":"13","author":"Bolton","year":"2017","journal-title":"PLoS Pathog"},{"key":"2021010207405031800_CIT0017","doi-asserted-by":"crossref","DOI":"10.3791\/57776","article-title":"Single-cell quantitation of mRNA and surface protein expression in simian immunodeficiency virus-infected CD4+ T cells isolated from rhesus macaques","author":"Tokarev","year":"2018","journal-title":"J Vis Exp"},{"key":"2021010207405031800_CIT0018","doi-asserted-by":"crossref","first-page":"20877","DOI":"10.1073\/pnas.0911796106","article-title":"The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1","volume":"106","author":"Cicala","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021010207405031800_CIT0019","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/mi.2009.104","article-title":"Monitoring alpha4beta7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection","volume":"2","author":"Wang","year":"2009","journal-title":"Mucosal Immunol"},{"key":"2021010207405031800_CIT0020","doi-asserted-by":"crossref","first-page":"e1007619","DOI":"10.1371\/journal.ppat.1007619","article-title":"Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection","volume":"15","author":"Pardons","year":"2019","journal-title":"PLoS Pathog"},{"key":"2021010207405031800_CIT0021","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1570162043485086","article-title":"Role of CD4 receptor down-regulation during HIV-1 infection","volume":"2","author":"Levesque","year":"2004","journal-title":"Curr HIV Res"},{"key":"2021010207405031800_CIT0022","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ebiom.2016.07.024","article-title":"HIV DNA set point is rapidly established in acute HIV infection and dramatically reduced by early ART","volume":"11","author":"Ananworanich","year":"2016","journal-title":"EBioMedicine"},{"key":"2021010207405031800_CIT0023","doi-asserted-by":"crossref","first-page":"e33948","DOI":"10.1371\/journal.pone.0033948","article-title":"Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection","volume":"7","author":"Ananworanich","year":"2012","journal-title":"PLoS One"},{"key":"2021010207405031800_CIT0024","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1182\/blood-2007-05-088435","article-title":"HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo","volume":"111","author":"Biancotto","year":"2008","journal-title":"Blood"},{"key":"2021010207405031800_CIT0025","doi-asserted-by":"crossref","first-page":"e01510-17","DOI":"10.1128\/JVI.01510-17","article-title":"alpha4beta7(+) CD4(+) effector\/effector memory T cells differentiate into productively and latently infected central memory T cells by transforming growth factor beta1 during HIV-1 infection","volume":"92","author":"Cheung","year":"2018","journal-title":"J Virol"},{"key":"2021010207405031800_CIT0026","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/381661a0","article-title":"Identification of a major co-receptor for primary isolates of HIV-1","volume":"381","author":"Deng","year":"1996","journal-title":"Nature"},{"key":"2021010207405031800_CIT0027","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/381667a0","article-title":"HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5","volume":"381","author":"Dragic","year":"1996","journal-title":"Nature"},{"key":"2021010207405031800_CIT0028","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.4049\/jimmunol.0903058","article-title":"Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T cells are highly permissive to HIV-1 infection","volume":"184","author":"Gosselin","year":"2010","journal-title":"J Immunol"},{"key":"2021010207405031800_CIT0029","doi-asserted-by":"crossref","first-page":"10189","DOI":"10.1128\/JVI.02529-10","article-title":"HLA-DR+ CD38+ CD4+ T lymphocytes have elevated CCR5 expression and produce the majority of R5-tropic HIV-1 RNA in vivo","volume":"85","author":"Meditz","year":"2011","journal-title":"J Virol"},{"key":"2021010207405031800_CIT0030","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/00002030-200006160-00004","article-title":"Role of CD38 in HIV-1 infection: an epiphenomenon of T-cell activation or an active player in virus\/host interactions?","volume":"14","author":"Savarino","year":"2000","journal-title":"AIDS"},{"key":"2021010207405031800_CIT0031","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/j.1460-2075.1990.tb08274.x","article-title":"HIV-1 replication is controlled at the level of T cell activation and proviral integration","volume":"9","author":"Stevenson","year":"1990","journal-title":"EMBO J"},{"key":"2021010207405031800_CIT0032","doi-asserted-by":"crossref","first-page":"e1003174","DOI":"10.1371\/journal.ppat.1003174","article-title":"Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies","volume":"9","author":"Eriksson","year":"2013","journal-title":"PLoS Pathog"},{"key":"2021010207405031800_CIT0033","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2013.09.020","article-title":"Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure","volume":"155","author":"Ho","year":"2013","journal-title":"Cell"},{"key":"2021010207405031800_CIT0034","doi-asserted-by":"crossref","first-page":"eaav3491","DOI":"10.1126\/scitranslmed.aav3491","article-title":"Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection","volume":"12","author":"Leyre","year":"2020","journal-title":"Sci Transl Med"},{"key":"2021010207405031800_CIT0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF02591400","article-title":"CD38: a multi-lineage cell activation molecule with a split personality","volume":"22","author":"Malavasi","year":"1992","journal-title":"Int J Clin Lab Res"},{"key":"2021010207405031800_CIT0036","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nm.1972","article-title":"HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation","volume":"15","author":"Chomont","year":"2009","journal-title":"Nat Med"},{"key":"2021010207405031800_CIT0037","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1126\/science.aaw7765","article-title":"Blocking \u03b14\u03b27 integrin binding to SIV does not improve virologic control","volume":"365","author":"Iwamoto","year":"2019","journal-title":"Science"},{"key":"2021010207405031800_CIT0038","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.aaw8562","article-title":"Lack of therapeutic efficacy of an antibody to \u03b14\u03b27 in SIVmac251-infected rhesus macaques","volume":"365","author":"Abbink","year":"2019","journal-title":"Science"},{"key":"2021010207405031800_CIT0039","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1126\/science.aav6695","article-title":"Evaluation of an antibody to \u03b14\u03b27 in the control of SIVmac239-nef-stop infection","volume":"365","author":"Di Mascio","year":"2019","journal-title":"Science"},{"key":"2021010207405031800_CIT0040","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/nm.3715","article-title":"Targeting \u03b14\u03b27 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection","volume":"20","author":"Byrareddy","year":"2014","journal-title":"Nat Med"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa497\/33384199\/ciaa497.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/11\/e735\/35349557\/ciaa497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/11\/e735\/35349557\/ciaa497.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T07:41:28Z","timestamp":1609573288000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/71\/11\/e735\/5827014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,4,29]]},"published-print":{"date-parts":[[2020,12,31]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa497","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,4,29]]}}}