{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:02:34Z","timestamp":1780581754879,"version":"3.54.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:00:00Z","timestamp":1588982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/01094"],"award-info":[{"award-number":["PI14\/01094"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14-01581"],"award-info":[{"award-number":["PI14-01581"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14CIII\/00011"],"award-info":[{"award-number":["PI14CIII\/00011"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish AIDS Research","award":["RD16\/0025\/0017"],"award-info":[{"award-number":["RD16\/0025\/0017"]}]},{"name":"Spanish AIDS Research","award":["RD16\/0025\/0018"],"award-info":[{"award-number":["RD16\/0025\/0018"]}]},{"name":"ISCIII-Subdirecci\u00f3n General de Evaluacion and European Funding for Regional Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This prospective study of 34 patients with HCV cirrhosis (17 HIV positive) with baseline clinically significant portal hypertension (CSPH; HVPG \u226510 mmHg) and SVR after DAA therapy showed that disappearance of CSPH (primary endpoint) is a rare event (6\/18 patients; 18%), indicating a persistent risk of clinical progression or death.<\/jats:p>","DOI":"10.1093\/cid\/ciaa502","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T19:13:18Z","timestamp":1588619598000},"page":"2726-2729","source":"Crossref","is-referenced-by-count":29,"title":["Persistence of Clinically Significant Portal Hypertension After Eradication of Hepatitis C Virus in Patients With Advanced Cirrhosis"],"prefix":"10.1093","volume":"71","author":[{"given":"Cristina","family":"D\u00edez","sequence":"first","affiliation":[{"name":"Unidad de Enfermedades Infecciosas\/VIH, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8541-8200","authenticated-orcid":false,"given":"Juan","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas\/VIH, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Iba\u00f1ez-Samaniego","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"},{"name":"Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elba","family":"Llop","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Madrid, Spain"},{"name":"Servicio de Aparato Digestivo, Hospital Universitario Puerta de Hierro, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro (IDIPHIM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"P\u00e9rez-Latorre","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas\/VIH, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda V","family":"Catalina","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"},{"name":"Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Honta\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"Unidad de VIH, Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Hospital Universitario La Paz (IdiPAZ), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A","family":"Jim\u00e9nez-Sousa","sequence":"additional","affiliation":[{"name":"Unidad de Infecci\u00f3n Viral e Inmunidad, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ald\u00e1miz-Echevarr\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas\/VIH, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Madrid, Spain"},{"name":"Servicio de Gastroenterolog\u00eda y Hepatolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (irycis), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Calleja","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Madrid, Spain"},{"name":"Servicio de Aparato Digestivo, Hospital Universitario Puerta de Hierro, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro (IDIPHIM), Madrid, Spain"},{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Albillos","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Madrid, Spain"},{"name":"Servicio de Gastroenterolog\u00eda y Hepatolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (irycis), Madrid, Spain"},{"name":"Facultad de Medicina, Universidad de Alcal\u00e1, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M","family":"Bell\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Resino","sequence":"additional","affiliation":[{"name":"Unidad de Infecci\u00f3n Viral e Inmunidad, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de VIH, Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Hospital Universitario La Paz (IdiPAZ), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ba\u00f1ares","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"},{"name":"Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Madrid, Spain"},{"name":"Facultad de Medicina, Universidad Complutense, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"2020121703243097000_CIT0001","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1053\/j.gastro.2007.05.024","article-title":"Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis","volume":"133","author":"Ripoll","year":"2007","journal-title":"Gastroenterology"},{"key":"2020121703243097000_CIT0002","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/hep.20871","article-title":"Influence of hepatic venous pressure gradient on the prediction of survival of patients with cirrhosis in the MELD era","volume":"42","author":"Ripoll","year":"2005","journal-title":"Hepatology"},{"key":"2020121703243097000_CIT0003","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jhep.2016.05.027","article-title":"Sustained virologic response to interferon-free therapies ameliorates HCV-induced portal hypertension","volume":"65","author":"Mandorfer","year":"2016","journal-title":"J Hepatol"},{"key":"2020121703243097000_CIT0004","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1053\/j.gastro.2017.07.016","article-title":"Effects of all-oral anti-viral therapy on HVPG and systemic hemodynamics in patients with hepatitis C virus-associated cirrhosis","volume":"153","author":"Lens","year":"2017","journal-title":"Gastroenterology"},{"key":"2020121703243097000_CIT0005","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/hep.20062","article-title":"The hepatic venous pressure gradient: anything worth doing should be done right","volume":"39","author":"Groszmann","year":"2004","journal-title":"Hepatology"},{"key":"2020121703243097000_CIT0006","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jinf.2019.09.020","article-title":"Mild profile improvement of immune biomarkers in HIV\/HCV-coinfected patients who removed hepatitis C after HCV treatment: a prospective study","volume":"80","author":"Garcia-Broncano","year":"2020","journal-title":"J Infect"},{"key":"2020121703243097000_CIT0007","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","author":"de Franchis","year":"2015","journal-title":"J Hepatol"},{"key":"2020121703243097000_CIT0008","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jhep.2014.08.010","article-title":"Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance","volume":"61","author":"Albillos","year":"2014","journal-title":"J Hepatol"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa502\/33712549\/ciaa502.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/10\/2726\/34932977\/ciaa502.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/10\/2726\/34932977\/ciaa502.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T19:49:47Z","timestamp":1608320987000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/71\/10\/2726\/5835009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,9]]},"references-count":8,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,5,9]]},"published-print":{"date-parts":[[2020,12,17]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa502","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,11,15]]},"published":{"date-parts":[[2020,5,9]]}}}