{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:58:07Z","timestamp":1784084287770,"version":"3.55.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","award":["20170258"],"award-info":[{"award-number":["20170258"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoord Foundation","doi-asserted-by":"publisher","award":["20170537"],"award-info":[{"award-number":["20170537"]}],"id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Knowledge on tuberculosis (TB) infection epidemiology in women of reproductive age living in TB-endemic areas is limited. We used a composite definition of TB infection in a cohort of pregnant women recruited in an Ethiopian city as a model for TB exposure patterns, and to identify factors associated with TB infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Women seeking antenatal care at public health facilities underwent structured interviews, physical examination, and QuantiFERON-TB Gold-Plus (QFT) testing. Women with symptoms compatible with TB disease, and all human immunodeficiency virus (HIV)\u2013positive women, were investigated for active TB by sputum bacteriological testing. TB infection (TB+) was defined as either positive QFT (\u2265\u20090.35 IU\/mL), self-reported previous active TB, or current active TB. Associations between TB infection and clinical, demographic, and socioeconomic characteristics were tested in multiple logistic regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 1834 participants, 679 (37.0%) met criteria for TB+ (80 [4.4%] previous active TB, 5 [0.3%] current active TB, and 594 [32.4%] QFT-positive without previous or current active TB). Age (annual adjusted odds ratio [AOR], 1.069 [95% confidence interval {CI}, 1.045\u20131.093]) and HIV infection (AOR, 1.43 [95% CI, 1.033\u20131.988]) were independently associated with TB+. The relationship with increasing age was only observed in HIV-negative women, and translated to an estimated annual risk of TB infection of 2.1% in HIV-negative women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>TB infection in women of reproductive age in Ethiopia was independently associated with HIV infection and increasing age, suggesting exposure to contagious TB and continuous acquisition of TB infection in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa561","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T11:08:31Z","timestamp":1589195311000},"page":"203-210","source":"Crossref","is-referenced-by-count":22,"title":["Tuberculosis Infection in Women of Reproductive Age: A Cross-sectional Study at Antenatal Care Clinics in an Ethiopian City"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3445-7741","authenticated-orcid":false,"given":"John","family":"Walles","sequence":"first","affiliation":[{"name":"Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malm\u00f6, Sweden"},{"name":"Department of Infectious Diseases, Central Hospital, Kristianstad, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fregenet","family":"Tesfaye","sequence":"additional","affiliation":[{"name":"Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malm\u00f6, Sweden"},{"name":"Armauer Hansen Research Institute, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Jansson","sequence":"additional","affiliation":[{"name":"Medical Microbiology, Department of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taye Tolera","family":"Balcha","sequence":"additional","affiliation":[{"name":"Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Stureg\u00e5rd","sequence":"additional","affiliation":[{"name":"Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malm\u00f6, Sweden"},{"name":"Department of Clinical Microbiology, Division of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mestawet","family":"Kefeni","sequence":"additional","affiliation":[{"name":"Adama Regional Laboratory, Adama, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadissa","family":"Merga","sequence":"additional","affiliation":[{"name":"Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institution of Clinical Sciences Lund, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niclas","family":"Winqvist","sequence":"additional","affiliation":[{"name":"Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Bj\u00f6rkman","sequence":"additional","affiliation":[{"name":"Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malm\u00f6, Sweden"},{"name":"Department of Infectious Diseases, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"2021071520093638400_CIT0001","volume-title":"Global tuberculosis report 2019","year":"2019"},{"key":"2021071520093638400_CIT0002","article-title":"Sex differences in tuberculosis burden and notifications in low- and middle-income countries\u202f: a systematic review and meta-analysis","volume":"19","author":"Horton","year":"2016","journal-title":"PLoS Med"},{"key":"2021071520093638400_CIT0003","first-page":"96","article-title":"A review of sex differences in the epidemiology of tuberculosis","volume":"2","author":"Holmes","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"2021071520093638400_CIT0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12889-018-5362-4","article-title":"TB epidemiology: where are the young women? 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