{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:50:08Z","timestamp":1776495008454,"version":"3.51.2"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department for International Development (DFID) under the MRC\/DFID Concordat agreement","award":["reference number MR\/J010391\/1"],"award-info":[{"award-number":["reference number MR\/J010391\/1"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:label\/>\n                  <jats:p>In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT1800942.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa609","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T20:52:58Z","timestamp":1589921578000},"page":"3222-3225","source":"Crossref","is-referenced-by-count":7,"title":["Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants\u2019 Nasopharynx: A Randomized Controlled Trial"],"prefix":"10.1093","volume":"71","author":[{"given":"Abdoulie","family":"Bojang","sequence":"first","affiliation":[{"name":"Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L","family":"Baines","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bully","family":"Camara","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Guerillot","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel S\u00e1nchez","family":"Marqu\u00e9s","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ousman","family":"Secka","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"D\u2019Alessandro","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bottomley","sequence":"additional","affiliation":[{"name":"Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin P","family":"Howden","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia"},{"name":"Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Roca","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,23]]},"reference":[{"key":"2021012201325190400_CIT0001","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1056\/NEJMoa1715474","article-title":"Azithromycin to reduce childhood mortality in sub-Saharan Africa","volume":"378","author":"Keenan","year":"2018","journal-title":"N Engl J Med"},{"key":"2021012201325190400_CIT0002","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/cid\/ciy254","article-title":"Long-term impact of oral azithromycin taken by Gambian women during labor on prevalence and antibiotic susceptibility of Streptococcus pneumoniae and Staphylococcus aureus in their infants: follow-up of a randomized clinical trial","volume":"67","author":"Bojang","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2021012201325190400_CIT0003","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1093\/jac\/dkz341","article-title":"Genomic investigation of Staphylococcus aureus recovered from Gambian women and newborns following an oral dose of intra-partum azithromycin","volume":"74","author":"Bojang","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"2021012201325190400_CIT0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plasmid.2015.01.001","article-title":"Transfer of antibiotic-resistance genes via phage-related mobile elements","volume":"79","author":"Brown-Jaque","year":"2015","journal-title":"Plasmid"},{"key":"2021012201325190400_CIT0005","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1139\/cjm-2018-0275","article-title":"Horizontal transfer of antibiotic resistance genes in clinical environments","volume":"65","author":"Lerminiaux","year":"2019","journal-title":"Can J Microbiol"},{"key":"2021012201325190400_CIT0006","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrmicro1232","article-title":"Studying plasmid horizontal transfer in situ: a critical review","volume":"3","author":"S\u00f8rensen","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"2021012201325190400_CIT0007","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1128\/AAC.50.3.1089-1091.2006","article-title":"Staphylococcus efflux msr(A) gene characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas isolates","volume":"50","author":"Ojo","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"2021012201325190400_CIT0008","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/mcpr.1997.0121","article-title":"Detection of erythromycin resistant methylase gene by the polymerase chain reaction","volume":"11","author":"Nawaz","year":"1997","journal-title":"Mol Cell Probes"},{"key":"2021012201325190400_CIT0009","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1574-6968.1999.tb13368.x","article-title":"Presence of erm gene classes in gram-positive bacteria of animal and human origin in Denmark","volume":"170","author":"Jensen","year":"1999","journal-title":"FEMS Microbiol Lett"},{"key":"2021012201325190400_CIT0010","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.diagmicrobio.2016.03.006","article-title":"High prevalence of Staphylococcus haemolyticus and Staphylococcus saprophyticus in environmental samples of a Tunisian hospital","volume":"85","author":"Dziri","year":"2016","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2021012201325190400_CIT0011","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1590\/0074-02760150356","article-title":"The prevalence of genotypes that determine resistance to macrolides, lincosamides, and streptogramins B compared with spiramycin susceptibility among erythromycin-resistant Staphylococcus epidermidis","volume":"111","author":"Juda","year":"2016","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2021012201325190400_CIT0012","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12884-015-0737-3","article-title":"Prevention of bacterial infections in the newborn by pre-delivery administration of azithromycin: study protocol of a randomized efficacy trial","volume":"15","author":"Roca","year":"2015","journal-title":"BMC Pregnancy Childbirth"},{"key":"2021012201325190400_CIT0013","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1186\/s12885-018-4400-z","article-title":"Microsatellite instability testing in colorectal cancer using the QiaXcel advanced platform","volume":"18","author":"F\u00f6rster","year":"2018","journal-title":"BMC Cancer"},{"key":"2021012201325190400_CIT0014","doi-asserted-by":"crossref","first-page":"565.e1","DOI":"10.1016\/j.cmi.2016.03.005","article-title":"Oral azithromycin given during labour decreases bacterial carriage in the mothers and their offspring: a double-blind randomized trial","volume":"22","author":"Roca","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"2021012201325190400_CIT0015","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12866-017-0982-x","article-title":"Short-term increase in prevalence of nasopharyngeal carriage of macrolide-resistant Staphylococcus aureus following mass drug administration with azithromycin for trachoma control","volume":"17","author":"Bojang","year":"2017","journal-title":"BMC Microbiol"},{"key":"2021012201325190400_CIT0016","doi-asserted-by":"crossref","first-page":"e00103","DOI":"10.1128\/mSphere.00103-18","article-title":"Impact of long-term erythromycin therapy on the oropharyngeal microbiome and resistance gene reservoir in non-cystic fibrosis bronchiectasis","volume":"3","author":"Choo","year":"2018","journal-title":"mSphere"},{"key":"2021012201325190400_CIT0017","first-page":"1736","article-title":"The effect of antibiotic selection pressure on the nasopharyngeal macrolide resistome: a cluster-randomized trial","volume":"67","author":"Keenan","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2021012201325190400_CIT0018","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1086\/324626","article-title":"Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications","volume":"34","author":"Leclercq","year":"2002","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa609\/33785071\/ciaa609.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/12\/3222\/35936253\/ciaa609.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/71\/12\/3222\/35936253\/ciaa609.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T04:14:08Z","timestamp":1611375248000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/71\/12\/3222\/5843412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,23]]},"references-count":18,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,5,23]]},"published-print":{"date-parts":[[2020,12,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa609","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,15]]},"published":{"date-parts":[[2020,5,23]]}}}