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The symposium attracted more than 300 Bordetella experts from 34 countries. They discussed the latest epidemiologic data and clinical aspects of pertussis, Bordetella biology and pathogenesis, immunology and vaccine development, and genomics and evolution. Advanced technological and methodological tools provided novel insights into the genomic diversity of Bordetella and a better understanding of pertussis disease and vaccine performance. New molecular approaches revealed previously unrecognized complexity of virulence gene regulation. Innovative insights into the immune responses to infection by Bordetella resulted in the development of new vaccine candidates. Such discoveries will aid in the design of more effective approaches to control pertussis and other Bordetella-related diseases.<\/jats:p>","DOI":"10.1093\/cid\/ciaa651","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T11:51:31Z","timestamp":1590148291000},"page":"2521-2526","source":"Crossref","is-referenced-by-count":7,"title":["Highlights of the 12th International<i>Bordetella<\/i>Symposium"],"prefix":"10.1093","volume":"71","author":[{"given":"Camille","family":"Locht","sequence":"first","affiliation":[{"name":"Universit\u00e9 Lille, Centre National de la Recherche Scientifique, Inserm, Centre Hospitalier Universitaire Lille, Institut Pasteur de Lille, U1019, Unit\u00e9 Mixte de Recherche 8204, Center for Infection and Immunity of Lille, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas H","family":"Carbonetti","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, 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