{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:38:05Z","timestamp":1790278685414,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"European Community\u2019s Seventh Framework Programme","award":["FP7\/2007\u20132013"],"award-info":[{"award-number":["FP7\/2007\u20132013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>People with diabetes have an increased risk of developing active tuberculosis (TB) and are more likely to have poor TB-treatment outcomes, which may impact on control of TB as the prevalence of diabetes is increasing worldwide. Blood transcriptomes are altered in patients with active TB relative to healthy individuals. The effects of diabetes and intermediate hyperglycemia (IH) on this transcriptomic signature were investigated to enhance understanding of immunological susceptibility in diabetes-TB comorbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Whole blood samples were collected from active TB patients with diabetes (glycated hemoglobin [HbA1c] \u22656.5%) or IH (HbA1c = 5.7% to &amp;lt;6.5%), TB-only patients, and healthy controls in 4 countries: South Africa, Romania, Indonesia, and Peru. Differential blood gene expression was determined by RNA-seq (n = 249).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Diabetes increased the magnitude of gene expression change in the host transcriptome in TB, notably showing an increase in genes associated with innate inflammatory and decrease in adaptive immune responses. Strikingly, patients with IH and TB exhibited blood transcriptomes much more similar to patients with diabetes-TB than to patients with only TB. Both diabetes-TB and IH-TB patients had a decreased type I interferon response relative to TB-only patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Comorbidity in individuals with both TB and diabetes is associated with altered transcriptomes, with an expected enhanced inflammation in the presence of both conditions, but also reduced type I interferon responses in comorbid patients, suggesting an unexpected uncoupling of the TB transcriptome phenotype. These immunological dysfunctions are also present in individuals with IH, showing that altered immunity to TB may also be present in this group. The TB disease outcomes in individuals with IH diagnosed with TB should be investigated further.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciaa751","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T15:10:47Z","timestamp":1591715447000},"page":"69-78","source":"Crossref","is-referenced-by-count":74,"title":["Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis"],"prefix":"10.1093","volume":"72","author":[{"given":"Clare","family":"Eckold","sequence":"first","affiliation":[{"name":"Tuberculosis Centre and Department of Infection and Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"University of Groningen, Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands"},{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"January","family":"Weiner","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Infection Biology, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachti","family":"Alisjahbana","sequence":"additional","affiliation":[{"name":"TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia"},{"name":"Hasan Sadikin General Hospital, Bandung, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca-Lelia","family":"Riza","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands"},{"name":"Human Genomics Laboratory, University of Medicine and Pharmacy, Craiova, Romania"},{"name":"Regional Centre for Human Genetics\u2013Dolj, Emergency Clinical County Hospital, Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Ronacher","sequence":"additional","affiliation":[{"name":"Mater Research Institute\u2013University of Queensland, Translational Research Institute, Brisbane, Australia"},{"name":"South Africa Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology\/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Coronel","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kerry-Barnard","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, St George\u2019s, University of London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanus T","family":"Malherbe","sequence":"additional","affiliation":[{"name":"South Africa Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology\/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanie","family":"Kleynhans","sequence":"additional","affiliation":[{"name":"South Africa Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology\/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Stanley","sequence":"additional","affiliation":[{"name":"South Africa Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology\/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rovina","family":"Ruslami","sequence":"additional","affiliation":[{"name":"TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Ioana","sequence":"additional","affiliation":[{"name":"Human Genomics Laboratory, University of Medicine and Pharmacy, Craiova, Romania"},{"name":"Regional Centre for Human Genetics\u2013Dolj, Emergency Clinical County Hospital, Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Ugarte-Gil","sequence":"additional","affiliation":[{"name":"Tuberculosis Centre and Department of Infection and Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom"},{"name":"School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Walzl","sequence":"additional","affiliation":[{"name":"South Africa Medical Research Council Centre for Tuberculosis Research, Department of Science and Technology\/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinout","family":"van Crevel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cisca","family":"Wijmenga","sequence":"additional","affiliation":[{"name":"University of Groningen, Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A","family":"Critchley","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, St George\u2019s, University of London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazel M","family":"Dockrell","sequence":"additional","affiliation":[{"name":"Tuberculosis Centre and Department of Infection and Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M","family":"Cliff","sequence":"additional","affiliation":[{"name":"Tuberculosis Centre and Department of Infection and Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TANDEM consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Dockrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Cliff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Eckold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Laurence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Aarnouste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"van Crevel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ruesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Lachmandas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Beigier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Golinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ottenhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Vrieling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Haks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Walzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ronacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Malherbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kleynhans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"van der Spuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Loxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Chegou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bosman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Thiart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wagman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Tshivhula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Selamolela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Prins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"du Plessis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"van Rensburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"du Toit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Critchley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kerry-Barnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Grint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Verrall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ioana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Riza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Cioboata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dudau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Nitu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Bazavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Olteanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Editoiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Florescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S G","family":"Popa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Firanescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Popa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Gheonea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bicuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lepadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Vladu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Clenciu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Streba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Demetrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ciurea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cimpoeru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ciocoiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Dorobantu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Plesea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E L","family":"Popescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cucu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Streata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Burada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Serban-Sosoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Panduru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Nicoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ciontea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Capitanescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Olaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Tataru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Papurica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Valutanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Dubreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Stamatoiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wijmenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ugarte-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Coronel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Limascca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Villaizan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Alisjahbana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Ruslami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Soetedjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Santoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Chaidir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Koesoemadinata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Susilawati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Annisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Livia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Yunivita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Soeroto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Permana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Imaculata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Gunawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Dewi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Apriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,13]]},"reference":[{"key":"2021072014085551000_CIT0001","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.chest.2017.02.032","article-title":"Defining a research agenda to address the converging epidemics of tuberculosis and diabetes: part 2: underlying biologic mechanisms","volume":"152","author":"Ronacher","year":"2017","journal-title":"Chest"},{"key":"2021072014085551000_CIT0002","doi-asserted-by":"crossref","first-page":"e0187967","DOI":"10.1371\/journal.pone.0187967","article-title":"Association between diabetes mellitus and active tuberculosis: a systematic review and meta-analysis","volume":"12","author":"Al-Rifai","year":"2017","journal-title":"PLoS One"},{"key":"2021072014085551000_CIT0003","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1741-7015-9-81","article-title":"The impact of diabetes on tuberculosis treatment outcomes: a systematic review","volume":"9","author":"Baker","year":"2011","journal-title":"BMC Med"},{"key":"2021072014085551000_CIT0004","volume-title":"IDF diabetes atlas","author":"International Diabetes Federation","year":"2017"},{"key":"2021072014085551000_CIT0005","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S2213-8587(14)70109-3","article-title":"Improving tuberculosis prevention and care through addressing the global diabetes epidemic: from evidence to policy and practice","volume":"2","author":"L\u00f6nnroth","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2021072014085551000_CIT0006","doi-asserted-by":"crossref","first-page":"812","DOI":"10.2337\/diabetes.52.3.812","article-title":"Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study","volume":"52","author":"Spranger","year":"2003","journal-title":"Diabetes"},{"key":"2021072014085551000_CIT0007","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s005920050147","article-title":"Circulating levels of interleukin-6, its soluble receptor and interleukin-6\/interleukin-6 receptor complexes in patients with type 2 diabetes mellitus","volume":"36","author":"Kado","year":"1999","journal-title":"Acta Diabetol"},{"key":"2021072014085551000_CIT0008","doi-asserted-by":"crossref","first-page":"e92977","DOI":"10.1371\/journal.pone.0092977","article-title":"Phagocytosis via complement or Fc-gamma receptors is compromised in monocytes from type 2 diabetes patients with chronic hyperglycemia","volume":"9","author":"Restrepo","year":"2014","journal-title":"PLoS One"},{"key":"2021072014085551000_CIT0009","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/infdis\/jit241","article-title":"Expansion of pathogen-specific T-helper 1 and T-helper 17 cells in pulmonary tuberculosis with coincident type 2 diabetes mellitus","volume":"208","author":"Kumar","year":"2013","journal-title":"J Infect Dis"},{"key":"2021072014085551000_CIT0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10096-007-0395-0","article-title":"The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus","volume":"27","author":"Stalenhoef","year":"2008","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2021072014085551000_CIT0011","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1440-1843.2012.02184.x","article-title":"Significance of the frequency of CD4+CD25+CD127\u2013 T-cells in patients with pulmonary tuberculosis and diabetes mellitus","volume":"17","author":"Sun","year":"2012","journal-title":"Respirology"},{"key":"2021072014085551000_CIT0012","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/imr.12257","article-title":"Acquired immunodeficiencies and tuberculosis: focus on HIV\/AIDS and diabetes mellitus","volume":"264","author":"Ronacher","year":"2015","journal-title":"Immunol Rev"},{"key":"2021072014085551000_CIT0013","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1164\/rccm.201711-2340OC","article-title":"Four-gene pan-African blood signature predicts progression to tuberculosis","volume":"197","author":"Suliman","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2021072014085551000_CIT0014","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"33","author":"American Diabetes Association","year":"2010","journal-title":"Diabetes Care"},{"key":"2021072014085551000_CIT0015","doi-asserted-by":"crossref","first-page":"e41367","DOI":"10.1371\/journal.pone.0041367","article-title":"Prevalence of diabetes and pre-diabetes and associated risk factors among tuberculosis patients in India","volume":"7","author":"Viswanathan","year":"2012","journal-title":"PLoS One"},{"key":"2021072014085551000_CIT0016","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.chest.2017.04.155","article-title":"Defining a research agenda to address the converging epidemics of tuberculosis and diabetes: part 1: epidemiology and clinical management","volume":"152","author":"Critchley","year":"2017","journal-title":"Chest"},{"key":"2021072014085551000_CIT0017","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09247","article-title":"An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis","volume":"466","author":"Berry","year":"2010","journal-title":"Nature"},{"key":"2021072014085551000_CIT0018","doi-asserted-by":"crossref","first-page":"e73230","DOI":"10.1371\/journal.pone.0073230","article-title":"A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis","volume":"8","author":"Joosten","year":"2013","journal-title":"PLoS One"},{"key":"2021072014085551000_CIT0019","doi-asserted-by":"crossref","first-page":"e46191","DOI":"10.1371\/journal.pone.0046191","article-title":"Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy","volume":"7","author":"Bloom","year":"2012","journal-title":"PLoS One"},{"key":"2021072014085551000_CIT0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/infdis\/jis499","article-title":"Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response","volume":"207","author":"Cliff","year":"2013","journal-title":"J Infect Dis"},{"key":"2021072014085551000_CIT0021","doi-asserted-by":"crossref","first-page":"e70630","DOI":"10.1371\/journal.pone.0070630","article-title":"Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers","volume":"8","author":"Bloom","year":"2013","journal-title":"PLoS One"},{"key":"2021072014085551000_CIT0022","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.1073\/pnas.1121072109","article-title":"Common patterns and disease-related signatures in tuberculosis and sarcoidosis","volume":"109","author":"Maertzdorf","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021072014085551000_CIT0023","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/s41598-017-01767-4","article-title":"Systems immunology of diabetes-tuberculosis comorbidity reveals signatures of disease complications","volume":"7","author":"Prada-Medina","year":"2017","journal-title":"Sci Rep"},{"key":"2021072014085551000_CIT0024","first-page":"780","article-title":"Diabetes mellitus among pulmonary tuberculosis patients from 4 tuberculosis-endemic countries: the TANDEM Study","volume":"70","author":"Ugarte-Gil","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2021072014085551000_CIT0025","doi-asserted-by":"crossref","first-page":"e87238","DOI":"10.1172\/jci.insight.87238","article-title":"Blood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis","volume":"1","author":"Roe","year":"2016","journal-title":"JCI Insight"},{"key":"2021072014085551000_CIT0026","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(15)01316-1","article-title":"A blood RNA signature for tuberculosis disease risk: a prospective cohort study","volume":"387","author":"Zak","year":"2016","journal-title":"Lancet"},{"key":"2021072014085551000_CIT0027","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.immuni.2008.05.012","article-title":"A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus","volume":"29","author":"Chaussabel","year":"2008","journal-title":"Immunity"},{"key":"2021072014085551000_CIT0028","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/ni.2789","article-title":"Molecular signatures of antibody responses derived from a systems biology study of five human vaccines","volume":"15","author":"Li","year":"2014","journal-title":"Nat Immunol"},{"key":"2021072014085551000_CIT0029","doi-asserted-by":"crossref","first-page":"e1001538","DOI":"10.1371\/journal.pmed.1001538","article-title":"Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study","volume":"10","author":"Kaforou","year":"2013","journal-title":"PLoS Med"},{"key":"2021072014085551000_CIT0030","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S2213-2600(16)00048-5","article-title":"Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis","volume":"4","author":"Sweeney","year":"2016","journal-title":"Lancet Respir Med"},{"key":"2021072014085551000_CIT0031","doi-asserted-by":"crossref","first-page":"e1002072","DOI":"10.1371\/journal.pmed.1002072","article-title":"Glycemic control and the risk of tuberculosis: a cohort study","volume":"13","author":"Lee","year":"2016","journal-title":"PLoS Med"},{"key":"2021072014085551000_CIT0032","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/S0140-6736(09)60553-5","article-title":"Stress hyperglycaemia","volume":"373","author":"Dungan","year":"2009","journal-title":"Lancet"},{"key":"2021072014085551000_CIT0033","author":"International Union Against Tuberculosis and Lung Disease\/World Health Organization","year":"2011"},{"key":"2021072014085551000_CIT0034","doi-asserted-by":"crossref","first-page":"e152","DOI":"10.1371\/journal.pmed.0050152","article-title":"Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies","volume":"5","author":"Jeon","year":"2008","journal-title":"PLoS Med"},{"key":"2021072014085551000_CIT0035","doi-asserted-by":"crossref","first-page":"100381","DOI":"10.1016\/j.epidem.2019.100381","article-title":"Epidemiological impact of targeted interventions for people with diabetes mellitus on tuberculosis transmission in India: modelling based predictions","volume":"30","author":"Awad","year":"2019","journal-title":"Epidemics"},{"key":"2021072014085551000_CIT0036","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.5588\/ijtld.17.0474","article-title":"Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in western India","volume":"21","author":"Mave","year":"2017","journal-title":"Int J Tuberc Lung Dis"},{"key":"2021072014085551000_CIT0037","doi-asserted-by":"crossref","first-page":"147","DOI":"10.5588\/pha.16.0114","article-title":"Diabetes and pre-diabetes in tuberculosis patients in western Kenya using point-of-care glycated haemoglobin","volume":"7","author":"Owiti","year":"2017","journal-title":"Public Health Action"},{"key":"2021072014085551000_CIT0038","doi-asserted-by":"crossref","first-page":"e45839","DOI":"10.1371\/journal.pone.0045839","article-title":"Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis","volume":"7","author":"Ottenhoff","year":"2012","journal-title":"PLoS One"},{"key":"2021072014085551000_CIT0039","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature13489","article-title":"Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk","volume":"511","author":"Mayer-Barber","year":"2014","journal-title":"Nature"},{"key":"2021072014085551000_CIT0040","first-page":"468","article-title":"Raised levels of IFN-gamma and IL-13 are associated with pre-diabetes amongst newly diagnosed patients with Tuberculosis","volume":"69","author":"Hasan","year":"2019","journal-title":"J Pak Med Assoc"},{"key":"2021072014085551000_CIT0041","doi-asserted-by":"crossref","first-page":"e112108","DOI":"10.1371\/journal.pone.0112108","article-title":"Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis","volume":"9","author":"Kumar","year":"2014","journal-title":"PLoS One"},{"key":"2021072014085551000_CIT0042","doi-asserted-by":"crossref","first-page":"e0178000","DOI":"10.1371\/journal.pone.0178000","article-title":"Prediabetes is associated with the modulation of antigen-specific Th1\/Tc1 and Th17\/Tc17 responses in latent Mycobacterium tuberculosis infection","volume":"12","author":"Kumar","year":"2017","journal-title":"PLoS One"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa751\/34243636\/ciaa751.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/72\/1\/69\/39170932\/ciaa751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/72\/1\/69\/39170932\/ciaa751.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T10:09:43Z","timestamp":1626775783000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/72\/1\/69\/5857148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,13]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,6,13]]},"published-print":{"date-parts":[[2021,1,23]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa751","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,1]]},"published":{"date-parts":[[2020,6,13]]}}}