{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T12:49:11Z","timestamp":1749559751417,"version":"3.37.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["950"],"award-info":[{"award-number":["950"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI007044","F32AI140511"],"award-info":[{"award-number":["T32AI007044","F32AI140511"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Penn Center for AIDS Research"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AI045008"],"award-info":[{"award-number":["P30AI045008"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from \u2264100 to \u2264200 cells\/\u00b5L resulted in a 3-fold increase in numbers screened. CrAg-prevalence was 3.5% at CD4 101\u2013200 and 6.2% \u2264100 cells\/\u00b5L. Six-month mortality was 21.4% (9\/42) in CrAg-positive CD4 \u2264100 cells\/\u00b5L and 3.2% (1\/31) in CrAg-positive CD4 101\u2013200 cells\/\u00b5L.<\/jats:p>","DOI":"10.1093\/cid\/ciaa899","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T19:15:26Z","timestamp":1593026126000},"page":"1635-1638","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100\u2013200 Cells\/\u00b5L in Botswana"],"prefix":"10.1093","volume":"72","author":[{"given":"Mark W","family":"Tenforde","sequence":"first","affiliation":[{"name":"Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA"},{"name":"Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA"},{"name":"Botswana-UPenn Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thandi","family":"Milton","sequence":"additional","affiliation":[{"name":"Botswana-UPenn Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikanyeng","family":"Rulaganyang","sequence":"additional","affiliation":[{"name":"Botswana-UPenn Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Muthoga","sequence":"additional","affiliation":[{"name":"Botswana-UPenn Partnership, Gaborone, Botswana"},{"name":"Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leabaneng","family":"Tawe","sequence":"additional","affiliation":[{"name":"Botswana-UPenn Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Chiller","sequence":"additional","affiliation":[{"name":"Mycotics Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Greene","sequence":"additional","affiliation":[{"name":"Mycotics Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Jordan","sequence":"additional","affiliation":[{"name":"Mycotics Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G","family":"Williams","sequence":"additional","affiliation":[{"name":"Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Owen","sequence":"additional","affiliation":[{"name":"Botswana-UPenn Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tshepo B","family":"Leeme","sequence":"additional","affiliation":[{"name":"Botswana-UPenn Partnership, Gaborone, Botswana"},{"name":"Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Boose","sequence":"additional","affiliation":[{"name":"Botswana-UPenn Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Ngidi","sequence":"additional","affiliation":[{"name":"Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madisa","family":"Mine","sequence":"additional","affiliation":[{"name":"Botswana National Health Laboratory, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph N","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Botswana-UPenn Partnership, Gaborone, Botswana"},{"name":"Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana"},{"name":"Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"2021050500473227800_CIT0001","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2021050500473227800_CIT0002","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1086\/597262","article-title":"Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South Africa","volume":"48","author":"Jarvis","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2021050500473227800_CIT0003","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/S0140-6736(15)60164-7","article-title":"Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial","volume":"385","author":"Mfinanga","year":"2015","journal-title":"Lancet"},{"key":"2021050500473227800_CIT0004","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/cid\/ciy567","article-title":"Impact of routine cryptococcal antigen screening and targeted preemptive fluconazole therapy in antiretroviral-naive human immunodeficiency virus-infected adults with CD4 cell counts &lt;100\/\u03bcL: a systematic review and meta-analysis","volume":"68","author":"Temfack","year":"2019","journal-title":"Clin Infect Dis"},{"author":"World Health Organization","key":"2021050500473227800_CIT0005"},{"key":"2021050500473227800_CIT0006","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/cid\/cix1143","article-title":"CD4 cell count threshold for cryptococcal antigen screening of HIV-infected individuals: a systematic review and meta-analysis","volume":"66","author":"Ford","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2021050500473227800_CIT0007","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/infdis\/jiy602","article-title":"HIV-associated cryptococcal meningitis occurring at relatively higher CD4 counts","volume":"219","author":"Tugume","year":"2019","journal-title":"J Infect Dis"},{"author":"World Health Organization","key":"2021050500473227800_CIT0008"},{"author":"Botswana Ministry of Health","key":"2021050500473227800_CIT0009"},{"key":"2021050500473227800_CIT0010","article-title":"Prevalence and sequelae of cryptococcal antigenemia in antiretroviral therapy-experienced populations: an evaluation of reflex cryptococcal antigen screening in Botswana","author":"Hurt","year":"2020","journal-title":"[manuscript published online ahead of print 1 April 2020]. Clin Infect Dis"},{"key":"2021050500473227800_CIT0011","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1212\/WNL.0000000000001561","article-title":"Lumbar puncture refusal in sub-Saharan Africa: a call for further understanding and intervention","volume":"84","author":"Thakur","year":"2015","journal-title":"Neurology"},{"key":"2021050500473227800_CIT0012","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/cid\/cix872","article-title":"High cryptococcal antigen titers in blood are predictive of subclinical cryptococcal meningitis among HIV-infected patients","volume":"66","author":"Wake","year":"2018","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciaa899\/33894999\/ciaa899.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/72\/9\/1635\/37796264\/ciaa899.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cid\/article-pdf\/72\/9\/1635\/37796264\/ciaa899.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:48:12Z","timestamp":1620175692000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/72\/9\/1635\/5865448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":12,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,6,30]]},"published-print":{"date-parts":[[2021,5,4]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciaa899","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"type":"print","value":"1058-4838"},{"type":"electronic","value":"1537-6591"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2020,6,30]]}}}