{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:01:20Z","timestamp":1791892880742,"version":"4.3.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:00:00Z","timestamp":1639180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Infective endocarditis (IE) following transcatheter aortic valve replacement (TAVR) has been associated with a dismal prognosis. However, scarce data exist on IE perivalvular extension (PEE) in such patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This multicenter study included 579 patients who had the diagnosis of definite IE at a median of 171 (53\u2013421) days following TAVR. PEE was defined as the presence of an intracardiac abscess, pseudoaneurysm, or fistula.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 105 patients (18.1%) were diagnosed with PEE (perivalvular abscess, pseudoaneurysm, fistula, or a combination in 87, 7, 7, and 4 patients, respectively). A history of chronic kidney disease (adjusted odds ratio [ORadj], 2.08; 95% confidence interval [CI]: 1.27\u20133.41; P\u2005=\u2005.003) and IE secondary to coagulase-negative staphylococci (ORadj, 2.71; 95% CI: 1.57\u20134.69; P\u2005&amp;lt;\u2005.001) were associated with an increased risk of PEE. Surgery was performed at index IE episode in 34 patients (32.4%) with PEE (vs 15.2% in patients without PEE, P\u2005&amp;lt;\u2005.001). In-hospital and 2-year mortality rates among PEE-IE patients were 36.5% and 69.4%, respectively. Factors independently associated with an increased mortality were the occurrence of other complications (stroke post-TAVR, acute renal failure, septic shock) and the lack of surgery at index IE hospitalization (padj\u2005&amp;lt;\u20050.05 for all).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PEE occurred in about one-fifth of IE post-TAVR patients, with the presence of coagulase-negative staphylococci and chronic kidney disease determining an increased risk. Patients with PEE-IE exhibited high early and late mortality rates, and surgery during IE hospitalization seemed to be associated with better outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab1004","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T20:20:14Z","timestamp":1639081214000},"page":"638-646","source":"Crossref","is-referenced-by-count":34,"title":["Perivalvular Extension of Infective Endocarditis After Transcatheter Aortic Valve Replacement"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0012-1289","authenticated-orcid":false,"given":"Vassili","family":"Panagides","sequence":"first","affiliation":[{"name":"Quebec Heart & Lung Institute, Laval University , Quebec City, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"del Val","sequence":"additional","affiliation":[{"name":"Quebec Heart & Lung Institute, Laval University , Quebec City, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-558X","authenticated-orcid":false,"given":"Mohamed","family":"Abdel-Wahab","sequence":"additional","affiliation":[{"name":"Heart Center, Leipzig University , Leipzig , Germany"},{"name":"Heart Center, Segeberger Kliniken , Bad Segeberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Mangner","sequence":"additional","affiliation":[{"name":"Heart Center, Leipzig University , Leipzig , Germany"},{"name":"Herzzentrum Dresden, Technische Universit\u00e4t , Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Durand","sequence":"additional","affiliation":[{"name":"Normandie Univ, CHU Rouen, Department of Cardiology , Rouen , 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