{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:31:08Z","timestamp":1784205068430,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:00:00Z","timestamp":1639180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1K24-AI143971"],"award-info":[{"award-number":["1K24-AI143971"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Exebacase, an antistaphylococcal lysin produced from a bacteriophage-encoded gene, is a promising adjunctive therapy for severe methicillin-resistant Staphylococcus aureus infections. We describe the first infant to receive exebacase, dosing, and pharmacokinetics. Exebacase may be safe and efficacious in children; however, further clinical trials are needed to optimize dosing.<\/jats:p>","DOI":"10.1093\/cid\/ciab1015","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T20:20:14Z","timestamp":1639081214000},"page":"338-341","source":"Crossref","is-referenced-by-count":12,"title":["Safety and Pharmacokinetics of Exebacase in an Infant With Disseminated <i>Staphylococcus aureus<\/i> Infection"],"prefix":"10.1093","volume":"75","author":[{"given":"Ganga S","family":"Moorthy","sequence":"first","affiliation":[{"name":"Duke University Medical Center , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel G","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , Durham, North Carolina , USA"},{"name":"Duke Clinical Research Institute , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi D","family":"Hornik","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , Durham, North Carolina , USA"},{"name":"Duke Clinical Research Institute , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Cassino","sequence":"additional","affiliation":[{"name":"ContraFect Corporation , Yonkers, New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz","family":"Ghahramani","sequence":"additional","affiliation":[{"name":"Inncelerex , Weehawken, New Jersey , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan R","family":"Kumar","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , Durham, North Carolina , USA"},{"name":"Duke Clinical Research Institute , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance G","family":"Fowler","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , Durham, North Carolina , USA"},{"name":"Duke Clinical Research Institute , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cohen-Wolkowiez","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , Durham, North Carolina , USA"},{"name":"Duke Clinical Research Institute , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,11]]},"reference":[{"key":"2022082520481078000_CIT0001","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41579-018-0147-4","article-title":"Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.","volume":"17","author":"Turner","year":"2019","journal-title":"Nat Rev Microbiol"},{"key":"2022082520481078000_CIT0002","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/CMR.05022-11","article-title":"Predictors of mortality in Staphylococcus aureus bacteremia.","volume":"25","author":"van Hal","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"2022082520481078000_CIT0003","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1093\/cid\/ciq146","article-title":"Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children [published correction appears in Clin Infect Dis 2011; 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