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We explore whether the elevation in 5-year mortality would have persisted if all adults with HIV had initiated antiretroviral therapy within 3 months of entering care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 82\u2005766 adults entering HIV care at North American AIDS Cohort Collaboration clinical sites in the United States, we computed mortality over 5 years since entry into HIV care under observed treatment patterns. We then used inverse probability weights to estimate mortality under universal early treatment. To compare mortality with those for similar individuals in the general population, we used National Center for Health Statistics data to construct a cohort representing the subset of the US population matched to study participants on key characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the entire study period (1999\u20132017), the 5-year mortality among adults with HIV was 7.9% (95% confidence interval [CI]: 7.6%\u20138.2%) higher than expected based on the US general population. Under universal early treatment, the elevation in mortality for people with HIV would have been 7.2% (95% CI: 5.8%\u20138.6%). In the most recent calendar period examined (2011\u20132017), the elevation in mortality for people with HIV was 2.6% (95% CI: 2.0%\u20133.3%) under observed treatment patterns and 2.1% (.0%\u20134.2%) under universal early treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Expanding early treatment may modestly reduce, but not eliminate, the elevation in mortality for people with HIV.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciab1030","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T12:08:55Z","timestamp":1639829335000},"page":"867-874","source":"Crossref","is-referenced-by-count":18,"title":["Five-Year Mortality for Adults Entering Human Immunodeficiency Virus Care Under Universal Early Treatment Compared With the General US Population"],"prefix":"10.1093","volume":"75","author":[{"given":"Jessie K","family":"Edwards","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of North 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