{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:40:50Z","timestamp":1792816850346,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Ministry of Health","award":["PHRC 2013-0397"],"award-info":[{"award-number":["PHRC 2013-0397"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early diagnosis and prompt initiation of specific antifungal treatment are essential for improving the prognosis of mucormycosis. We aimed to assess the performance of serum Mucorales quantitative polymerase chain reaction (qPCR) for the early diagnosis and follow-up of mucormycosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled 232 patients with suspicion of invasive mold disease, evaluated using standard imaging and mycological procedures. Thirteen additional patients with proven or probable mucormycosis were included to analyze DNA load kinetics. Serum samples were collected twice-a-week for Mucorales qPCR tests targeting the Mucorales genera Lichtheimia, Rhizomucor, and Mucor\/Rhizopus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The sensitivity was 85.2%, specificity 89.8%, and positive and negative likelihood ratios 8.3 and 0.17, respectively in this prospective study. The first Mucorales qPCR-positive serum was observed a median of 4 days (interquartile range [IQR], 0\u20139) before sampling of the first mycological or histological positive specimen and a median of one day (IQR, \u22122 to 6) before the first imaging was performed. Negativity of Mucorales qPCR within seven days after liposomal-amphotericin B initiation was associated with an 85% lower 30-day mortality rate (adjusted hazard ratio\u2005=\u20050\u00b715, 95% confidence interval [.03\u2013.73], P\u2005=\u2005.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study argues for the inclusion of qPCR for the detection of circulating Mucorales DNA for mucormycosis diagnosis and follow-up after treatment initiation. Positive results should be added to the criteria for the consensual definitions from the European Organization for the Research and Treatment of Cancer\/Mycoses Study Group Education and Research Consortium (EORTC\/MSGERC), as already done for Aspergillus PCR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciab1066","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T15:09:37Z","timestamp":1641222577000},"page":"777-785","source":"Crossref","is-referenced-by-count":179,"title":["Evaluation of Serum Mucorales Polymerase Chain Reaction (PCR) for the Diagnosis of Mucormycoses: The MODIMUCOR Prospective Trial"],"prefix":"10.1093","volume":"75","author":[{"given":"Laurence","family":"Millon","sequence":"first","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie , Centre hospitalier universtaire (CHU) Besan\u00e7on, Besan\u00e7on , France"},{"name":"Unit\u00e9 mixte de recherche (UMR) 6249 Centre national de la recherche scientifique (CNRS) Chrono-Environnement, Univ Bourgogne Franche-Comt\u00e9 , Besan\u00e7on , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Caillot","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology, CHU Dijon , Dijon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Berceanu","sequence":"additional","affiliation":[{"name":"Service d\u2019Hematologie , CHU Besan\u00e7on, Besan\u00e7on , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Bretagne","sequence":"additional","affiliation":[{"name":"Institut Pasteur, CNRS, Molecular Mycology Unit, National Reference Center for Invasive Mycoses and Antifungals , UMR 2000, Paris , France"},{"name":"Laboratoire de Parasitologie-Mycologie, H\u00f4pital Saint Louis , AP-HP, Paris , France"},{"name":"Universit\u00e9 de Paris , Paris , 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