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Here we describe the Food and Drug Administration\u2019s rationale for selecting 2.4 mg\/kg in pediatric patients weighing less than 20 kg based on literature review and independent analyses.<\/jats:p>","DOI":"10.1093\/cid\/ciab149","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T20:28:26Z","timestamp":1613161706000},"page":"903-906","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Body Weight and Age on the Pharmacokinetics of Dihydroartemisinin: Food and Drug Administration Basis for Dose Determination of Artesunate for Injection in Pediatric Patients With Severe Malaria"],"prefix":"10.1093","volume":"73","author":[{"given":"Eliford","family":"Kitabi","sequence":"first","affiliation":[{"name":"Division of Pharmacometrics, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"Bensman","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Pharmacology, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C","family":"Earp","sequence":"additional","affiliation":[{"name":"Division of Pharmacometrics, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakshina M","family":"Chilukuri","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Pharmacology, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Anti-infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Ball","sequence":"additional","affiliation":[{"name":"Division of Anti-infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"O\u2019Shaughnessy","sequence":"additional","affiliation":[{"name":"Division of Anti-infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug 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