{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:07:25Z","timestamp":1740128845941,"version":"3.37.3"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5 U01 AI41110"],"award-info":[{"award-number":["5 U01 AI41110"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pediatric AIDS Clinical Trials Group","award":["1 U01 AI068616"],"award-info":[{"award-number":["1 U01 AI068616"]}]},{"name":"International and Domestic Pediatric and Maternal HIV Clinical Trials Network","award":["N01-DK-9-001\/HHSN267200800001C"],"award-info":[{"award-number":["N01-DK-9-001\/HHSN267200800001C"]}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["AI068632","HHSN267200603425C"],"award-info":[{"award-number":["AI068632","HHSN267200603425C"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the frequency and associated characteristics of chronic comorbid conditions and obstetrical complications among pregnant women with human immunodeficiency virus (HIV) and receiving antiretroviral therapy (ART) in comparison to those without HIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared 2 independent concurrent US pregnancy cohorts: (1) with HIV (International Maternal Pediatric Adolescent AIDS Clinical Trials Protocol P1025, 2002\u20132013) and (2) without HIV (Consortium for Safe Labor Study, 2002\u20132007). Outcomes were \u22652 chronic comorbid conditions and obstetrical complications. For women with HIV, we assessed whether late prenatal care (\u226514 weeks), starting ART in an earlier era (2002\u20132008), and a detectable viral load at delivery (\u2265400 copies\/mL) were associated with study outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We assessed 2868 deliveries (n\u2005=\u20052574 women) with HIV and receiving ART and 211\u2005910 deliveries (n\u2005=\u2005193\u2005170 women) without HIV. Women with HIV were more likely to have \u22652 chronic comorbid conditions versus those without HIV (10 vs 3%; adjusted OR [AOR]: 2.96; 95% CI: 2.58\u20133.41). Women with HIV were slightly less likely to have obstetrical complications versus those without HIV (both 17%; AOR: .84; 95% CI: .75\u2013.94), but secondarily, higher odds of preterm birth &amp;lt;37 weeks. Late entry to prenatal care and starting ART in an earlier era were associated with a lower likelihood of \u22652 chronic comorbidities and obstetrical complications; detectable viral load at delivery was associated with a higher likelihood of obstetric complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pregnant women with HIV receiving ART have more chronic comorbid conditions, but not necessarily obstetrical complications, than their peers without HIV.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciab203","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T12:34:51Z","timestamp":1614602091000},"page":"969-978","source":"Crossref","is-referenced-by-count":5,"title":["Profile of Chronic Comorbid Conditions and Obstetrical Complications Among Pregnant Women With Human Immunodeficiency Virus and Receiving Antiretroviral Therapy in the United States"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-556X","authenticated-orcid":false,"given":"Kartik K","family":"Venkatesh","sequence":"first","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leavitt","family":"Morrison","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T. 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Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth E","family":"Tuomala","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital\/Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Stek","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S","family":"Read","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T. 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