{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:41:58Z","timestamp":1786369318100,"version":"build-2736575974"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Taiwan Centers for Disease Control"},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 107-2314-B-037-106-MY3"],"award-info":[{"award-number":["MOST 107-2314-B-037-106-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 109-2314-B-037-085-MY3"],"award-info":[{"award-number":["MOST 109-2314-B-037-085-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kaohsiung Municipal Ta-Tung Hospital","award":["KMTTH-108-R007"],"award-info":[{"award-number":["KMTTH-108-R007"]}]},{"name":"Kaohsiung Municipal Ta-Tung Hospital","award":["KMTTH-109-R001"],"award-info":[{"award-number":["KMTTH-109-R001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Poor control of diabetes mellitus (DM) increases active tuberculosis (TB) risk. Understanding risk factors for latent TB infection (LTBI) in this population and intervention completion rates is crucial for policy making.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Under a collaborative multidisciplinary team consisting of public health professionals, endocrinologists, and pulmonologists, patients aged &amp;gt;45 years with poorly controlled DM (pDM), defined as having a glycated hemoglobin level of \u22659% within the preceding year, were enrolled by endocrinologists from 2 hospitals; these patients underwent LTBI screening by using QuantiFERON (QFT). Once-weekly isoniazid and rifapentine for 12 weeks (3HP) or daily isoniazid for 9 months (9H) was administered by pulmonologists. QFT-positivity predictors were evaluated using logistic regression. Completion rates and safety were also investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 980 patients with pDM (age: 64.2\u2005\u00b1\u20059.7 years), 261 (26.6%) were QFT-positive. Age, DM duration, chronic kidney disease stage \u22653, and dipeptidyl peptidase-4 inhibitor use, not using metformin, were associated with QFT-positivity. Preventive therapy (3HP: 138; 9H: 62) was administered in 200 (76.6%) QFT-positive patients. The completion rates of 3HP and 9H were 84.1% and 79.0%, respectively (P\u2005=\u2005.494). Nine (6.5%) and zero patients in the 3HP and 9H groups, respectively, developed systemic drug reactions (P\u2005=\u2005.059); 78.3% and 45.2% had \u22651 adverse drug reactions (P\u2005&amp;lt;\u2005.001); and post-treatment QFT conversion rates were 32% and 20%, respectively (P\u2005=\u2005.228).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LTBI prevalence exceeds 25% in elderly patients with pDM. Under care from a collaborative multidisciplinary team, the completion rate of preventive therapy, regardless of regimen could approach, or even exceed 80% in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab209","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T20:14:54Z","timestamp":1614629694000},"page":"e1252-e1260","source":"Crossref","is-referenced-by-count":40,"title":["Completion Rate and Safety of Programmatic Screening and Treatment for Latent Tuberculosis Infection in Elderly Patients With Poorly Controlled Diabetic Mellitus: A Prospective Multicenter Study"],"prefix":"10.1093","volume":"73","author":[{"given":"Hung-Ling","family":"Huang","sequence":"first","affiliation":[{"name":"Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"},{"name":"Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung, 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Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Hsuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"},{"name":"Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Shih","family":"Chin","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Liang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"},{"name":"Center for Liquid Biopsy and Cohort 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