{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T06:13:47Z","timestamp":1782022427661,"version":"3.54.5"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000996","name":"Department of Foreign Affairs and Trade, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The emergence and spread of Plasmodium falciparum parasites that lack HRP2\/3 proteins and the resulting decreased utility of HRP2-based malaria rapid diagnostic tests (RDTs) prompted the World Health Organization and other global health stakeholders to prioritize the discovery of novel diagnostic biomarkers for malaria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To address this pressing need, we adopted a dual, systematic approach by conducting a systematic review of the literature for publications on diagnostic biomarkers for uncomplicated malaria and a systematic in silico analysis of P. falciparum proteomics data for Plasmodium proteins with favorable diagnostic features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our complementary analyses led us to 2 novel malaria diagnostic biomarkers compatible for use in an RDT format: glyceraldehyde 3-phosphate dehydrogenase and dihydrofolate reductase-thymidylate synthase.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, our results pave the way for the development of next-generation malaria RDTs based on new antigens by identifying 2 lead candidates with favorable diagnostic features and partially de-risked product development prospects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab251","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T20:36:06Z","timestamp":1633034166000},"page":"40-51","source":"Crossref","is-referenced-by-count":10,"title":["A Dual, Systematic Approach to Malaria Diagnostic Biomarker Discovery"],"prefix":"10.1093","volume":"74","author":[{"given":"Seda","family":"Yerlikaya","sequence":"first","affiliation":[{"name":"Foundation for Innovative New Diagnostics, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewurama D A","family":"Owusu","sequence":"additional","affiliation":[{"name":"Foundation for Innovative New Diagnostics, Geneva, Switzerland"},{"name":"Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustina","family":"Frimpong","sequence":"additional","affiliation":[{"name":"West Africa Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana"},{"name":"Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana"},{"name":"African Institute for Mathematical Sciences, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Kirk","family":"DeLisle","sequence":"additional","affiliation":[{"name":"Colorado Computational, LLC, Longmont, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier C","family":"Ding","sequence":"additional","affiliation":[{"name":"Foundation for Innovative New Diagnostics, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"2022011123263976900_CIT0001","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1128\/jcm.29.8.1629-1634.1991","article-title":"Identification of Plasmodium falciparum histidine-rich protein 2 in the plasma of humans with malaria","volume":"29","author":"Parra","year":"1991","journal-title":"J Clin Microbiol"},{"key":"2022011123263976900_CIT0002","author":"World 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