{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:25:46Z","timestamp":1781072746527,"version":"3.54.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1033740"],"award-info":[{"award-number":["OPP1033740"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["AID-OAA-A-11-00048"],"award-info":[{"award-number":["AID-OAA-A-11-00048"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000278","name":"Department for International Development, UK Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000278","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institut Bertrand Buisson","award":["2011_TNT_01"],"award-info":[{"award-number":["2011_TNT_01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The diagnostic gold standard for onchocerciasis relies on identification and enumeration of (skin-dwelling) Onchocerca volvulus microfilariae (mf) using the skin snip technique (SST). In a recent study, blood-borne Loa loa mf were found by SST in individuals heavily infected with L. loa, and microscopically misidentified as O. volvulus due to their superficially similar morphology. This study investigates the relationship between L. loa microfilarial density (Loa MFD) and the probability of testing SST positive.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 1053 participants from the (onchocerciasis and loiasis coendemic) East Region in Cameroon were tested for (1) Loa MFD in blood samples, (2) O. volvulus presence by SST, and (3) Immunoglobulin (Ig) G4 antibody positivity to Ov16 by rapid diagnostic test (RDT). A Classification and Regression Tree (CART) model was used to perform a supervised classification of SST status and identify a Loa MFD threshold above which it is highly likely to find L. loa mf in skin snips.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 1011 Ov16-negative individuals, 28 (2.8%) tested SST positive and 150 (14.8%) were L. loa positive. The range of Loa MFD was 0\u201385 200 mf\/mL. The CART model subdivided the sample into 2 Loa MFD classes with a discrimination threshold of 4080 (95% CI, 2180\u201312 240) mf\/mL. The probability of being SST positive exceeded 27% when Loa MFD was &amp;gt;4080 mf\/mL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The probability of finding L. loa mf by SST increases significantly with Loa MFD. Skin-snip polymerase chain reaction would be useful when monitoring onchocerciasis prevalence by SST in onchocerciasis\u2013loiasis coendemic areas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab255","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T20:19:57Z","timestamp":1616185197000},"page":"S158-S164","source":"Crossref","is-referenced-by-count":4,"title":["Unusual Localization of Blood-Borne <i>Loa loa<\/i> Microfilariae in the Skin Depends on Microfilarial Density in the Blood: Implications for Onchocerciasis Diagnosis in Coendemic Areas"],"prefix":"10.1093","volume":"72","author":[{"given":"Yannick","family":"Niamsi-Emalio","sequence":"first","affiliation":[{"name":"Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues C","family":"Nana-Djeunga","sequence":"additional","affiliation":[{"name":"Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric B","family":"Chesnais","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement (IRD), UMI233\/INSERM U1175, Universit\u00e9 de Montpellier , Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien D S","family":"Pion","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement (IRD), UMI233\/INSERM U1175, Universit\u00e9 de Montpellier , Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules B","family":"Tchatchueng-Mbougua","sequence":"additional","affiliation":[{"name":"Service d\u2019Epid\u00e9miologie, Centre Pasteur du Cameroun, Membre du R\u00e9seau International des Instituts Pasteur, Yaound\u00e9, Cameroun"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Boussinesq","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement (IRD), UMI233\/INSERM U1175, Universit\u00e9 de Montpellier , Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5031-3361","authenticated-orcid":false,"given":"Mar\u00eda-Gloria","family":"Bas\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Dep artment of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kamgno","sequence":"additional","affiliation":[{"name":"Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), Yaound\u00e9, 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