{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:42:01Z","timestamp":1793756521111,"version":"4.6.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Institut Pasteur, Inserm, Sant\u00e9 Publique France"},{"name":"Programme Hospitalier Recherche Clinique"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Listeriosis is caused by the foodborne pathogen Listeria monocytogenes. It can present as a maternal\u2013neonatal infection. We implemented a nationwide prospective cohort and analyzed the features of neonatal listeriosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied all neonates born alive from mothers with microbiologically proven maternal\u2013neonatal listeriosis enrolled from November 2009 to December 2017. We analyzed presentation, neonatal outcome at discharge, and predictors of severe presentation and outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We studied 189 infants; 133 of 189 (70%) had abnormal clinical status at birth, including acute respiratory distress in 106 of 189 (56%). There were 132 of 189 (70%) infants who developed early-onset listeriosis and 12 of 189 (6%) who developed late-onset listeriosis; all presented with acute meningitis. There were 17 of 189 (9%) infants who had major adverse outcomes: 3%, (5 of 189) death; 6% (12 of 189), severe brain injury; and 2% (3 of 189), severe bronchopulmonary dysplasia. Fifteen of 17 infants were born &amp;lt;34 weeks of gestation (P\u2005&amp;lt;\u2005.0001 vs infants born \u226534 weeks of gestation). Maternal antimicrobial treatment \u22651 day before delivery was associated with a significant decrease in presentation severity for the infant, resulting in significantly fewer inotropic drugs, fluid resuscitation, and mechanical ventilation requirement (odds ratio, 0.23; 95% confidence interval, 0.09\u20130.51; P\u2005&amp;lt;\u2005.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Antenatal maternal antimicrobial treatment is associated with reduced neonatal listeriosis severity, justifying the prescription of preemptive maternal antimicrobial therapy when maternal\u2013fetal listeriosis is suspected. Neonatal outcome is better than reported earlier, and its major determinant is gestational age at birth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT01520597.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab337","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T23:58:42Z","timestamp":1618617522000},"page":"8-16","source":"Crossref","is-referenced-by-count":51,"title":["Neonatal Listeriosis Presentation and Outcome: A Prospective Study of 189 Cases"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-3620","authenticated-orcid":false,"given":"Caroline","family":"Charlier","sequence":"first","affiliation":[{"name":"Institut Pasteur, Biology of Infection Unit, Paris, France"},{"name":"Institut Pasteur, French National Reference Center and World Health Organization Collaborating Center Listeria, Paris, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1117, Paris, France"},{"name":"Universit\u00e9 de Paris, Paris, France"},{"name":"Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Institut Imagine, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Kermorvant-Duchemin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris, France"},{"name":"Necker-Enfants Malades University Hospital, Department of Neonatology, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Perrodeau","sequence":"additional","affiliation":[{"name":"Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9, METHODS Team, Unit\u00e9 Mixte de Recherche 1153, Inserm, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Moura","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Biology of Infection Unit, Paris, France"},{"name":"Institut Pasteur, French National Reference Center and World Health Organization Collaborating Center Listeria, Paris, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1117, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myl\u00e8ne M","family":"Maury","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Biology of Infection Unit, Paris, France"},{"name":"Institut Pasteur, French National Reference Center and World Health Organization Collaborating Center Listeria, Paris, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1117, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Bracq-Dieye","sequence":"additional","affiliation":[{"name":"Institut Pasteur, French National Reference Center and World Health Organization Collaborating Center Listeria, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Thouvenot","sequence":"additional","affiliation":[{"name":"Institut Pasteur, French National Reference Center and World Health Organization Collaborating Center Listeria, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Val\u00e8s","sequence":"additional","affiliation":[{"name":"Institut Pasteur, French National Reference Center and World Health Organization Collaborating Center Listeria, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Leclercq","sequence":"additional","affiliation":[{"name":"Institut Pasteur, French National Reference Center and World Health Organization Collaborating Center Listeria, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ravaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris, France"},{"name":"Centre of Research in Epidemiology and Statistics Sorbonne Paris Cit\u00e9, METHODS Team, Unit\u00e9 Mixte de Recherche 1153, Inserm, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-1063","authenticated-orcid":false,"given":"Marc","family":"Lecuit","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Biology of Infection Unit, Paris, France"},{"name":"Institut Pasteur, French National Reference Center and World Health Organization Collaborating Center Listeria, Paris, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1117, Paris, France"},{"name":"Universit\u00e9 de Paris, Paris, France"},{"name":"Necker-Enfants Malades University Hospital, Department of Infectious Diseases and Tropical Medicine, Institut Imagine, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"2022011123262873100_CIT0001","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1469-0691.2009.03109.x","article-title":"Listeriosis: a resurgent foodborne infection","volume":"16","author":"Allerberger","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"2022011123262873100_CIT0002","article-title":"Changes in epidemiology and surveillance of listeriosis in France","volume-title":"International symposium on problems of listeriosis","author":"de 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