{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:33:21Z","timestamp":1788050001630,"version":"build-2784847793"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1133670"],"award-info":[{"award-number":["APP1133670"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1175509"],"award-info":[{"award-number":["APP1175509"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1088735"],"award-info":[{"award-number":["APP1088735"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Staphylococcus aureus is a common cause of bacteremia, yet the epidemiology and predictors of poor outcome remain inadequately defined in childhood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>ISAIAH (Invasive Staphylococcus aureus Infections and Hospitalizations in children) is a prospective, cross-sectional study of S. aureus bacteremia (SAB) in children hospitalized in Australia and New Zealand over 24 months (2017\u20132018).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 552 SABs were identified (incidence 4.4\/100 000\/year). Indigenous children, those from lower socioeconomic areas and neonates were overrepresented. Although 90-day mortality was infrequent, one-third experienced the composite of: length of stay &amp;gt;30 days (26%), intensive care unit admission (20%), relapse (4%), or death (3%). Predictors of mortality included prematurity (adjusted odds ratio [aOR],16.8; 95% confidence interval [CI], 1.6\u2013296.9), multifocal infection (aOR, 22.6; CI, 1.4\u2013498.5), necrotizing pneumonia (aOR, 38.9; CI, 1.7\u20131754.6), multiorgan dysfunction (aOR, 26.5; CI, 4.1\u2013268.8), and empiric vancomycin (aOR, 15.7; CI, 1.6\u2013434.4); while infectious diseases (ID) consultation (aOR, 0.07; CI .004\u2013.9) was protective. Neither MRSA nor vancomycin trough targets impacted survival; however, empiric vancomycin was associated with nephrotoxicity (OR, 3.1; 95% CI 1.3\u20138.1).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>High SAB incidence was demonstrated and for the first time in a pediatric setting, necrotizing pneumonia and multifocal infection were predictors of mortality, while ID consultation was protective. The need to reevaluate pediatric vancomycin trough targets and limit unnecessary empiric vancomycin exposure to reduce poor outcomes and nephrotoxicity is highlighted. One in 3 children experienced considerable SAB morbidity; therefore, pediatric inclusion in future SAB comparator trials is paramount to improve outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab510","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T19:20:05Z","timestamp":1622834405000},"page":"604-613","source":"Crossref","is-referenced-by-count":42,"title":["Pediatric <i>Staphylococcus aureus<\/i> Bacteremia: Clinical Spectrum and Predictors of Poor Outcome"],"prefix":"10.1093","volume":"74","author":[{"given":"Anita J","family":"Campbell","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Perth Children\u2019s Hospital , Perth ,","place":["Australia"]},{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute , Perth ,","place":["Australia"]},{"name":"School of Medicine, University of Western Australia , Perth ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila S","family":"Al Yazidi","sequence":"additional","affiliation":[{"name":"Child Health Department, Sultan Qaboos University Hospital , Muscat ,","place":["Oman"]},{"name":"Department of Immunology and Infectious Diseases, Sydney Children\u2019s Hospital , Randwick, Sydney ,","place":["Australia"]},{"name":"Children\u2019s Department of Infectious Diseases and Microbiology, Children\u2019s Hospital at Westmead , New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linny K","family":"Phuong","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Infectious Diseases Unit, Royal Children\u2019s Hospital , Melbourne ,","place":["Australia"]},{"name":"Infection and Immunity Group, Murdoch Children\u2019s Research Institute , Melbourne ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Wagga Wagga Base Hospital , Wagga Wagga ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma J","family":"Best","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Child and Youth Health, University of Auckland , Auckland ,","place":["New Zealand"]},{"name":"National Immunisation Advisory Centre, University of Auckland , Auckland ,","place":["New Zealand"]},{"name":"Department of Infectious Diseases, Starship Children\u2019s Hospital , Auckland ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel H","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Child and Youth Health, University of Auckland , Auckland ,","place":["New Zealand"]},{"name":"Department of Infectious Diseases, Starship Children\u2019s Hospital , Auckland ,","place":["New Zealand"]},{"name":"Department of Paediatrics, Kidz First Hospital , Auckland ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Child and Youth Health, University of Auckland , Auckland ,","place":["New Zealand"]},{"name":"Department of Infectious Diseases, Starship Children\u2019s Hospital , Auckland ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Athan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Barwon Health , Geelong ,","place":["Australia"]},{"name":"School of Medicine, Deakin University , Geelong ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N","family":"Britton","sequence":"additional","affiliation":[{"name":"Children\u2019s Department of Infectious Diseases and Microbiology, Children\u2019s Hospital at Westmead , New South Wales ,","place":["Australia"]},{"name":"Sydney Medical School and Marie Bashir Institute, University of Sydney , Sydney ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope A","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Infectious Diseases Unit, Royal Children\u2019s Hospital , Melbourne ,","place":["Australia"]},{"name":"Infection and Immunity Group, Murdoch Children\u2019s Research Institute , Melbourne ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coen T","family":"Butters","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Infectious Diseases Unit, Royal Children\u2019s Hospital , Melbourne ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R","family":"Carapetis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Perth Children\u2019s Hospital , Perth ,","place":["Australia"]},{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute , Perth ,","place":["Australia"]},{"name":"School of Medicine, University of Western Australia , Perth ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha S","family":"Ching","sequence":"additional","affiliation":[{"name":"Infection and Immunity, Monash Children\u2019s Hospital, Monash Health , Clayton, Victoria ,","place":["Australia"]},{"name":"Department of Paediatrics, Monash University , Clayton ,","place":["Australia"]},{"name":"Department of General Paediatrics, Monash Children\u2019s Hospital, Monash Health , Melbourne ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W","family":"Coombs","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PathWest Laboratory Medicine, QEII Medical Centre, Royal Perth Hospital and Fiona Stanley Hospital , Perth ,","place":["Western Australia"]},{"name":"College of Science, Health, Engineering and Education, Murdoch University , Perth ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise A","family":"Daley","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PathWest Laboratory Medicine, QEII Medical Centre, Royal Perth Hospital and Fiona Stanley Hospital , Perth ,","place":["Western Australia"]},{"name":"Australian Group on Antimicrobial Resistance, Australian Commission on Safety and Quality in Healthcare , Sydney ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua R","family":"Francis","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , Darwin ,","place":["Australia"]},{"name":"Department of Paediatrics, Royal Darwin Hospital , Darwin ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te-Yu","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Royal Darwin Hospital , Darwin ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel","family":"Mowlaboccus","sequence":"additional","affiliation":[{"name":"College of Science, Health, Engineering and Education, Murdoch University , Perth ,","place":["Australia"]},{"name":"School of Biomedical Sciences, University of Western Australia , Perth ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Nourse","sequence":"additional","affiliation":[{"name":"Infection Management and Prevention Service, Queensland Children\u2019s Hospital , Brisbane ,","place":["Australia"]},{"name":"Faculty of Medicine, University of Queensland , Queensland ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Ojaimi","sequence":"additional","affiliation":[{"name":"Infection and Immunity, Monash Children\u2019s Hospital, Monash Health , Clayton, Victoria ,","place":["Australia"]},{"name":"Department of Paediatrics, Monash University , Clayton ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Barwon Health , Geelong ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Vasilunas","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Women\u2019s and Children\u2019s Hospital , Adelaide ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"McMullan","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Sydney Children\u2019s Hospital , Randwick, Sydney ,","place":["Australia"]},{"name":"School of Women\u2019s and Children\u2019s Health, University of New South Wales , Sydney ,","place":["Australia"]},{"name":"National Centre for Infections in Cancer, University of Melbourne , Melbourne ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C","family":"Blyth","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Perth Children\u2019s Hospital , Perth ,","place":["Australia"]},{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute , Perth ,","place":["Australia"]},{"name":"School of Medicine, University of Western Australia , Perth ,","place":["Australia"]},{"name":"Department of Microbiology, Pathest Laboratory Medicine, QEII Medical Centre , Perth ,","place":["Western Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha C","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Perth Children\u2019s Hospital , Perth ,","place":["Australia"]},{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute , Perth ,","place":["Australia"]},{"name":"School of Medicine, University of Western Australia , Perth ,","place":["Australia"]},{"name":"Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , Darwin ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,5]]},"reference":[{"key":"2024111411414668300_CIT0001","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S1473-3099(14)71003-5","article-title":"Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002-13: a multicentre retrospective cohort study","volume":"15","author":"Schlapbach","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"2024111411414668300_CIT0002","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1136\/adc.2005.074229","article-title":"Review of Staphylococcus aureus infections requiring admission to a paediatric intensive care unit","volume":"90","author":"Miles","year":"2005","journal-title":"Arch Dis Child"},{"key":"2024111411414668300_CIT0003","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10096-015-2391-0","article-title":"A comparison of paediatric and adult infectious diseases consultations in Australia and New Zealand","volume":"34","author":"Blyth","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2024111411414668300_CIT0004","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1001\/archinte.163.17.2066","article-title":"Clinical identifiers of complicated Staphylococcus aureus bacteremia","volume":"163","author":"Fowler","year":"2003","journal-title":"Arch Intern Med"},{"key":"2024111411414668300_CIT0005","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"2024111411414668300_CIT0006","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting","volume":"36","author":"Horan","year":"2008","journal-title":"Am J Infect Control"},{"key":"2024111411414668300_CIT0007","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00008480-200106000-00006","article-title":"Pediatric sepsis and multiple organ dysfunction syndrome","volume":"13","author":"Despond","year":"2001","journal-title":"Curr Opin Pediatr"},{"key":"2024111411414668300_CIT0008","volume-title":"eTG complete [digital] Staphylococcus aureus bacteraemia","year":"2019"},{"key":"2024111411414668300_CIT0009","volume-title":"Clinical and Laboratory Standards Institute, performance standards for antimicrobial susceptibility testing; eighteenth informational supplement","author":"Wayne","year":"2018"},{"key":"2024111411414668300_CIT0010","author":"European Committee on Antimicrobial Susceptibility Testing.","year":"2016"},{"key":"2024111411414668300_CIT0011"},{"key":"2024111411414668300_CIT0012","author":"Australian Bureau of Statistics.","year":"2018"},{"key":"2024111411414668300_CIT0013","year":"2018"},{"key":"2024111411414668300_CIT0014","year":"2016"},{"key":"2024111411414668300_CIT0015","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/pch\/16.5.276","article-title":"Staphylococcus aureus bloodstream infections in children: a population-based assessment","volume":"16","author":"Vanderkooi","year":"2011","journal-title":"Paediatr Child Health"},{"key":"2024111411414668300_CIT0016","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/01.inf.0000261112.53035.4c","article-title":"Changing epidemiology of pediatric Staphylococcus aureus bacteremia in Denmark from 1971 through 2000","volume":"26","author":"Frederiksen","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"2024111411414668300_CIT0017","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1001\/jamapediatrics.2016.1477","article-title":"Epidemiology and mortality of Staphylococcus aureus bacteremia in Australian and New Zealand children","volume":"170","author":"McMullan","year":"2016","journal-title":"JAMA Pediatr"},{"key":"2024111411414668300_CIT0018","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1086\/598219","article-title":"High burden of staphylococcal disease in indigenous communities","volume":"199","author":"Turnidge","year":"2009","journal-title":"J Infect Dis"},{"key":"2024111411414668300_CIT0019","year":"2019"},{"key":"2024111411414668300_CIT0020","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5694\/j.1326-5377.2007.tb01054.x","article-title":"The epidemiology of invasive group A streptococcal disease in Victoria, Australia","volume":"186","author":"O\u2019Grady","year":"2007","journal-title":"Med J Aust"},{"key":"2024111411414668300_CIT0021","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1017\/S0950268816000704","article-title":"Meningococcal disease epidemiology in Australia 10 years after implementation of a national conjugate meningococcal C immunization programme","volume":"144","author":"Lawrence","year":"2016","journal-title":"Epidemiol Infect"},{"key":"2024111411414668300_CIT0022","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1097\/INF.0000000000002071","article-title":"Vaccine impact on long-term trends in invasive bacterial disease in New Zealand children","volume":"37","author":"Walls","year":"2018","journal-title":"Pediatr Infect Dis J"},{"key":"2024111411414668300_CIT0023","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jinf.2010.09.021","article-title":"Association of methicillin-resistant Staphylococcus aureus (MRSA) USA300 genotype with mortality in MRSA bacteremia","volume":"61","author":"Kempker","year":"2010","journal-title":"J Infect"},{"key":"2024111411414668300_CIT0024","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jhin.2017.11.021","article-title":"Central and peripheral line-associated bloodstream infections in Australian neonatal and paediatric intensive care units: findings from a comprehensive Victorian surveillance network, 2008-2016","volume":"99","author":"Worth","year":"2018","journal-title":"J Hospital Infect"},{"key":"2024111411414668300_CIT0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jhin.2015.07.002","article-title":"Antibiotic treatment duration and prevention of complications in neonatal Staphylococcus aureus bacteraemia","volume":"91","author":"Kempley","year":"2015","journal-title":"J Hosp Infect"},{"key":"2024111411414668300_CIT0026","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1053\/j.semperi.2012.06.004","article-title":"Methicillin-resistant Staphylococcus aureus in the neonatal intensive care unit","volume":"36","author":"Nelson","year":"2012","journal-title":"Semin Perinatol"},{"key":"2024111411414668300_CIT0027","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1542\/peds.2004-0043","article-title":"Features of invasive staphylococcal disease in neonates","volume":"114","author":"Healy","year":"2004","journal-title":"Pediatrics"},{"key":"2024111411414668300_CIT0028","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jpeds.2018.12.002","article-title":"Risk factors for complications in children with Staphylococcus aureus bacteremia","volume":"208","author":"Hamdy","year":"2019","journal-title":"J Pediatr"},{"key":"2024111411414668300_CIT0029","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/CMR.05022-11","article-title":"Predictors of mortality in Staphylococcus aureus bacteremia","volume":"25","author":"van Hal","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"2024111411414668300_CIT0030","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.cmi.2015.05.026","article-title":"Impact of routine bedside infectious disease consultation on clinical management and outcome of Staphylococcus aureus bacteraemia in adults","volume":"21","author":"Saunderson","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"2024111411414668300_CIT0031","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3947\/ic.2013.45.2.202","article-title":"Impact of methicillin-resistance on mortality in children and neonates with Staphylococcus aureus bacteremia: a meta-analysis","volume":"45","author":"Park","year":"2013","journal-title":"Infect Chemother"},{"key":"2024111411414668300_CIT0032","doi-asserted-by":"crossref","first-page":"e78396","DOI":"10.1371\/journal.pone.0078396","article-title":"Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children\u2019s hospital in Cape Town, South Africa","volume":"8","author":"Naidoo","year":"2013","journal-title":"PLoS One"},{"key":"2024111411414668300_CIT0033","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1086\/649793","article-title":"Hospital-acquired Staphylococcus aureus infections at Texas Children\u2019s Hospital, 2001-2007","volume":"31","author":"Hult\u00e9n","year":"2015","journal-title":"Infect Control Hospital Epidemiol"},{"key":"2024111411414668300_CIT0034","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/INF.0000000000000991","article-title":"Healthcare-associated Staphylococcus aureus bacteremia in children: evidence for reverse vancomycin creep and impact of vancomycin trough values on outcome","volume":"35","author":"McNeil","year":"2016","journal-title":"Pediatr Infect Dis J"},{"key":"2024111411414668300_CIT0035","doi-asserted-by":"crossref","first-page":"ofaa538","DOI":"10.1093\/ofid\/ofaa538","article-title":"Vancomycin exposure and acute kidney injury outcome: a snapshot from the CAMERA2 study","volume":"7","author":"Liu","year":"2020","journal-title":"Open Forum Infect Dis"},{"key":"2024111411414668300_CIT0036","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/INF.0b013e318299f75c","article-title":"Desired vancomycin trough serum concentration for treating invasive methicillin-resistant staphylococcal infections","volume":"32","author":"Frymoyer","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"2024111411414668300_CIT0037","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/cid\/cir034","article-title":"Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary","volume":"52","author":"Liu","year":"2011","journal-title":"Clin Infect Dis"},{"key":"2024111411414668300_CIT0038","first-page":"1304","article-title":"Impact of antimicrobial stewardship and rapid diagnostics in children with Staphylococcus aureus bacteremia","volume":"3","author":"Welch","year":"2020","journal-title":"JACCP"},{"key":"2024111411414668300_CIT0039","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s12879-018-3312-5","article-title":"Infection characteristics and treatment of Staphylococcus aureus bacteraemia at a tertiary children\u2019s hospital","volume":"18","author":"Munro","year":"2018","journal-title":"BMC Infect Dis"},{"key":"2024111411414668300_CIT0040","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1086\/317421","article-title":"Staphylococcus aureus bacteremia: predictors of 30-day mortality in a large cohort","volume":"31","author":"Mylotte","year":"2000","journal-title":"Clin Infect Dis"},{"key":"2024111411414668300_CIT0041","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1086\/519263","article-title":"Factors predicting mortality in necrotizing community-acquired pneumonia caused by Staphylococcus aureus containing Panton-Valentine leukocidin","volume":"45","author":"Gillet","year":"2007","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/advance-article-pdf\/doi\/10.1093\/cid\/ciab510\/41717352\/ciab510.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/74\/4\/604\/42672672\/ciab510.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/74\/4\/604\/42672672\/ciab510.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:36:19Z","timestamp":1731587779000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/74\/4\/604\/6293981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,5]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,6,5]]},"published-print":{"date-parts":[[2022,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciab510","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2,15]]},"published":{"date-parts":[[2021,6,5]]}}}