{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:28:32Z","timestamp":1791581312526,"version":"4.3.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["CDC-RFA-CK17-1701"],"award-info":[{"award-number":["CDC-RFA-CK17-1701"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The COVID-19 pandemic has resulted in unprecedented healthcare challenges, and COVID-19 has been linked to secondary infections. Candidemia, a fungal healthcare-associated infection, has been described in patients hospitalized with severe COVID-19. However, studies of candidemia and COVID-19 coinfection have been limited in sample size and geographic scope. We assessed differences in patients with candidemia with and without a COVID-19 diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a case-level analysis using population-based candidemia surveillance data collected through the Centers for Disease Control and Prevention\u2019s Emerging Infections Program during April\u2013August 2020 to compare characteristics of candidemia patients with and without a positive test for COVID-19 in the 30 days before their Candida culture using chi-square or Fisher\u2019s exact tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 251 candidemia patients included, 64 (25.5%) were positive for SARS-CoV-2. Liver disease, solid-organ malignancies, and prior surgeries were each &amp;gt;3 times more common in patients without COVID-19 coinfection, whereas intensive care unit\u2013level care, mechanical ventilation, having a central venous catheter, and receipt of corticosteroids and immunosuppressants were each &amp;gt;1.3 times more common in patients with COVID-19. All-cause in-hospital fatality was 2 times higher among those with COVID-19 (62.5%) than without (32.1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One-quarter of candidemia patients had COVID-19. These patients were less likely to have certain underlying conditions and recent surgery commonly associated with candidemia and more likely to have acute risk factors linked to COVID-19 care, including immunosuppressive medications. Given the high mortality, it is important for clinicians to remain vigilant and take proactive measures to prevent candidemia in patients with COVID-19.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciab562","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T15:11:24Z","timestamp":1623942684000},"page":"802-811","source":"Crossref","is-referenced-by-count":118,"title":["The Landscape of Candidemia During the Coronavirus Disease 2019 (COVID-19) Pandemic"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2421-4444","authenticated-orcid":false,"given":"Emma E","family":"Seagle","sequence":"first","affiliation":[{"name":"ASRT, Inc, Atlanta, Georgia, USA"},{"name":"Mycotic Disease Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan R","family":"Jackson","sequence":"additional","affiliation":[{"name":"Mycotic Disease Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn R","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Mycotic Disease Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ourania","family":"Georgacopoulos","sequence":"additional","affiliation":[{"name":"Mycotic Disease Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie S","family":"Nunnally","sequence":"additional","affiliation":[{"name":"Mycotic Disease Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Roland","sequence":"additional","affiliation":[{"name":"California Emerging Infections Program, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devra M","family":"Barter","sequence":"additional","affiliation":[{"name":"Colorado Department of Public Health and Environment, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L","family":"Johnston","sequence":"additional","affiliation":[{"name":"Colorado Department of Public Health and Environment, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Czaja","sequence":"additional","affiliation":[{"name":"Colorado Department of Public Health and Environment, Denver, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazal","family":"Kayalioglu","sequence":"additional","affiliation":[{"name":"Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Clogher","sequence":"additional","affiliation":[{"name":"Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Revis","sequence":"additional","affiliation":[{"name":"Atlanta VA Medical Center, Atlanta, Georgia, USA"},{"name":"Foundation for Atlanta Veterans Education and Research, Atlanta, Georgia, USA"},{"name":"Georgia Emerging Infections Program, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M","family":"Farley","sequence":"additional","affiliation":[{"name":"Atlanta VA Medical Center, Atlanta, Georgia, USA"},{"name":"Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee H","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Shrum","family":"Davis","sequence":"additional","affiliation":[{"name":"New Mexico Emerging Infections Program, University of New Mexico, Albuquerque, New Mexico,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin C","family":"Phipps","sequence":"additional","affiliation":[{"name":"New Mexico Emerging Infections Program, University of New Mexico, Albuquerque, New Mexico,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda L","family":"Tesini","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Schaffner","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffanie M","family":"Markus","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan M","family":"Lyman","sequence":"additional","affiliation":[{"name":"Mycotic Disease Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"2022030918454413500_CIT0001","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/cid\/ciy776","article-title":"Estimation of direct healthcare costs of fungal diseases in the United 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