{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:25:48Z","timestamp":1782951948593,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","award":["2015 00060746"],"award-info":[{"award-number":["2015 00060746"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["NIH\/NICHD- R21-HD060524"],"award-info":[{"award-number":["NIH\/NICHD- R21-HD060524"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["EDCTP- IP.07.31080.002"],"award-info":[{"award-number":["EDCTP- IP.07.31080.002"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Malaria in pregnancy (MiP) contributes significantly to infant mortality rates in sub-Saharan Africa and has consequences on survivors, such as preterm birth and low birth weight. However, its impact on long-term neurocognitive development in children remains unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Our prospective cohort included pregnant women and their live-born singletons from the Malaria in Pregnancy Preventive Alternative Drugs clinical trial. MiP was assessed using microscopy and real-time quantitative polymerase chain reaction (qPCR). Neurocognitive development in children was assessed using the Mullen Scales of Early Learning and the Kaufman Assessment Battery for Children, 2nd edition (KABC-II), at 1 and 6 years of age, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 493 pregnant women, 196 (40%) were infected with malaria at least once: 121 (31%) with placental malaria diagnosed by qPCR. Multiple linear regression B-coefficients showed that impaired gross motor scores were associated with MiP at least once (\u22122.55; confidence interval [95% CI]: \u22125.15, 0.05), placental malaria by qPCR (\u22124.95; 95% CI: \u22127.65, \u22122.24), and high parasite density at delivery (\u22121.92; 95% CI: \u22123.86, 0.02) after adjustment. Malaria and high parasite density at the second antenatal care visit were associated with lower KABC-II Non-Verbal Index scores at 6 years (\u22122.57 [95% CI: \u22124.86, \u22120.28] and \u22121.91 [\u22123.51, \u22120.32]), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This prospective cohort study provides evidence that MiP, particularly late term, could have important negative consequences on child development at 1 and 6 years of age. Mechanisms behind this association must be further investigated and diagnostic methods in low-income countries should be strengthened to provide adequate treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT00811421.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab569","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T19:13:53Z","timestamp":1624043633000},"page":"766-775","source":"Crossref","is-referenced-by-count":25,"title":["The Effects of Malaria in Pregnancy on Neurocognitive Development in Children at 1 and 6 Years of Age in Benin: A Prospective Mother\u2013Child Cohort"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6758-9185","authenticated-orcid":false,"given":"Amanda","family":"Garrison","sequence":"first","affiliation":[{"name":"Ecole des Hautes Etudes en Sant\u00e9 Publique (EHESP), Rennes, France"},{"name":"Universit\u00e9 de Paris, Center of Research in Epidemiology and Statistics (CRESS), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Institut National de la Recherche Agronomique, Paris, France"},{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Boivin","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neurology\/Ophthalmology, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Fi\u00e9vet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, M\u00e8re et Enfant Face aux Infections Tropicales, Institut de Recherche Pour le D\u00e9veloppement, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rom\u00e9o","family":"Zoumenou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, M\u00e8re et Enfant Face aux Infections Tropicales, Institut de Recherche Pour le D\u00e9veloppement, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules M","family":"Alao","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, Centre Hospitalier Universitaire de la M\u00e8re et de l\u2019Enfant\u2013Lagune de Cotonou, Cotonou, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille","family":"Massougbodji","sequence":"additional","affiliation":[{"name":"Facult\u00e9 des Sciences de la Sant\u00e9, Universit\u00e9 d\u2019Abomey-Calavi, Cotonou, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Cot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, M\u00e8re et Enfant Face aux Infections Tropicales, Institut de Recherche Pour le D\u00e9veloppement, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Bodeau-Livinec","sequence":"additional","affiliation":[{"name":"Ecole des Hautes Etudes en Sant\u00e9 Publique (EHESP), Rennes, France"},{"name":"Universit\u00e9 de Paris, Center of Research in Epidemiology and Statistics (CRESS), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Institut National de la Recherche Agronomique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"2022030918453021800_CIT0001","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1473-3099(07)70021-X","article-title":"Epidemiology and burden of malaria in pregnancy","volume":"7","author":"Desai","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"2022030918453021800_CIT0002","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.semperi.2019.03.018","article-title":"An overview of malaria in pregnancy","volume":"43","author":"Bauserman","year":"2019","journal-title":"Semin Perinatol"},{"key":"2022030918453021800_CIT0003","first-page":"186","article-title":"Malaria and pregnancy: a global health perspective","volume":"2","author":"Schantz-Dunn","year":"2009","journal-title":"Rev Obstet Gynecol"},{"key":"2022030918453021800_CIT0004","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1128\/CMR.17.4.760-769.2004","article-title":"Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa","volume":"17","author":"Guyatt","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"2022030918453021800_CIT0005","doi-asserted-by":"crossref","first-page":"e000342","DOI":"10.1136\/bmjopen-2011-000342","article-title":"First malaria infections in a cohort of infants in Benin: biological, environmental and genetic determinants. 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