{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:50:54Z","timestamp":1781880654812,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R21CA242439-01"],"award-info":[{"award-number":["1R21CA242439-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Allery and Infectious Diseases","award":["1R21-AI147992"],"award-info":[{"award-number":["1R21-AI147992"]}]},{"DOI":"10.13039\/100006108","name":"National Center For Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR002553"],"award-info":[{"award-number":["UL1TR002553"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BERD Methods Core","award":["UL1TR002553"],"award-info":[{"award-number":["UL1TR002553"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Placentally transferred maternal immunoglobulin G (IgG) protects against pathogens in early life, yet vertically transmitted infections can interfere with transplacental IgG transfer. Although human cytomegalovirus (HCMV) is the most common placentally-transmitted viral infection worldwide, the impact of congenital HCMV (cCMV) infection on transplacental IgG transfer has been underexplored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We evaluated total and antigen-specific maternal and cord blood IgG levels and transplacental IgG transfer efficiency in a US-based cohort of 93 mother-infant pairs including 27 cCMV-infected and 66 cCMV-uninfected pairs, of which 29 infants were born to HCMV-seropositive nontransmitting mothers and 37 to HCMV-seronegative mothers. Controls were matched on sex, race\/ethnicity, maternal age, and delivery year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Transplacental IgG transfer efficiency was decreased by 23% (95% confidence interval [CI] 10\u201336%, P\u2005=\u2005.0079) in cCMV-infected pairs and 75% of this effect (95% CI 28\u2013174%, P\u2005=\u2005.0085) was mediated by elevated maternal IgG levels (ie, hypergammaglobulinemia) in HCMV-transmitting women. Despite reduced transfer efficiency, IgG levels were similar in cord blood from infants with and without cCMV infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results indicate that cCMV infection moderately reduces transplacental IgG transfer efficiency due to maternal hypergammaglobulinemia; however, infants with and without cCMV infection had similar antigen-specific IgG levels, suggesting comparable protection from maternal IgG acquired via transplacental transfer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab627","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T03:12:43Z","timestamp":1626145963000},"page":"1131-1140","source":"Crossref","is-referenced-by-count":8,"title":["Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia"],"prefix":"10.1093","volume":"74","author":[{"given":"Eleanor C","family":"Semmes","sequence":"first","affiliation":[{"name":"Medical Scientist Training Program, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA"},{"name":"Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA"},{"name":"Duke Children\u2019s Health & Discovery Initiative, Department of Pediatrics, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuk Hang","family":"Li","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-9920","authenticated-orcid":false,"given":"Jillian H","family":"Hurst","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA"},{"name":"Duke Children\u2019s Health & Discovery Initiative, Department of Pediatrics, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zidanyue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Niedzwiecki","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve G","family":"Fouda","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA"},{"name":"Department of Pediatrics, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA"},{"name":"Duke Children\u2019s Health & Discovery Initiative, Department of Pediatrics, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Kurtzberg","sequence":"additional","affiliation":[{"name":"Carolinas Cord Blood Bank, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle M","family":"Walsh","sequence":"additional","affiliation":[{"name":"Duke Children\u2019s Health & Discovery Initiative, Department of Pediatrics, Duke University, Durham, North Carolina, USA"},{"name":"Department of Neurosurgery, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sallie R","family":"Permar","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA"},{"name":"Duke Children\u2019s Health & Discovery Initiative, Department of Pediatrics, Duke University, Durham, North Carolina, USA"},{"name":"Department of Pediatrics, Weill Cornell School of Medicine, New York City, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"2022040917420013300_CIT0001","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3390\/vaccines7040129","article-title":"Impact of maternal immunity on congenital cytomegalovirus birth prevalence and infant outcomes: a systematic review","volume":"7","author":"Coppola","year":"2019","journal-title":"Vaccines (Basel)"},{"key":"2022040917420013300_CIT0002","doi-asserted-by":"crossref","first-page":"e00030","DOI":"10.1128\/JVI.00030-18","article-title":"Advancing our understanding of protective maternal immunity as a guide for development of vaccines to reduce congenital cytomegalovirus infections","volume":"92","author":"Permar","year":"2018","journal-title":"J 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