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In this review, 40 of these experimental animal studies and 104 clinical reports are compiled with a focus on albendazole. Among the 144 articles involving an estimated 1034 patients and 2561 animals, 4.1% were inconclusive or vague regarding the use of benzimidazoles. Of the remaining 138 articles, 90.5% found benzimidazoles to be safe and effective (885 patients, 2530 animals), 4.3% as safe but ineffective (73 patients, 3 animals), and 5.0% caused adverse reactions (7 patients, 28 animals). Among those clinical reports that described a confirmed diagnosis of neuroangiostrongyliasis in which albendazole monotherapy was used, 100% reported high efficacy (743 patients, 479 animals). In those where albendazole-corticosteroid co-therapy was used, 97.87% reported it to be effective (323 patients, 130 animals).<\/jats:p>","DOI":"10.1093\/cid\/ciab730","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T09:35:04Z","timestamp":1630056904000},"page":"1293-1302","source":"Crossref","is-referenced-by-count":32,"title":["Clinical Efficacy and Safety of Albendazole and Other Benzimidazole Anthelmintics for Rat Lungworm Disease (Neuroangiostrongyliasis): A Systematic Analysis of Clinical Reports and Animal Studies"],"prefix":"10.1093","volume":"74","author":[{"given":"John","family":"Jacob","sequence":"first","affiliation":[{"name":"Daniel K. Inouye College of Pharmacy, University of Hawaii\u2013Hilo, Hilo, Hawaii, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argon","family":"Steel","sequence":"additional","affiliation":[{"name":"Daniel K. Inouye College of Pharmacy, University of Hawaii\u2013Hilo, Hilo, Hawaii, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhain","family":"Lin","sequence":"additional","affiliation":[{"name":"Daniel K. Inouye College of Pharmacy, University of Hawaii\u2013Hilo, Hilo, Hawaii, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University Clermont Auvergne, Clermont Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Z\u00f6eller","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Goethe University Frankfurt, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9824-0509","authenticated-orcid":false,"given":"Susan","family":"Jarvi","sequence":"additional","affiliation":[{"name":"Daniel K. 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