{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:08:48Z","timestamp":1740128928959,"version":"3.37.3"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK94818"],"award-info":[{"award-number":["R01-DK94818"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hepatitis B Research Network","award":["NCT01924455"],"award-info":[{"award-number":["NCT01924455"]}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24AA022523","K24DA034621","K24DK078772","P30 DK043351","U01 DK082919"],"award-info":[{"award-number":["K24AA022523","K24DA034621","K24DK078772","P30 DK043351","U01 DK082919"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Massachusetts General Hospital Research Scholars Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Fatty liver disease (FLD) and hepatitis B virus (HBV) infection occur commonly in human immunodeficiency virus (HIV). FLD resolution is associated with improvement in lipoproteins in HIV-uninfected patients. We evaluated changes in FLD in an HBV\/HIV-coinfected cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>One hundred eight HBV\/HIV-coinfected adults with baseline liver biopsies were followed every 24 weeks (median, 166 weeks) and 60 had follow-up biopsies. Baseline FLD categories (none, \u22655% steatosis, steatohepatitis), their change, and relationships with clinical and lipid\/lipoprotein parameters were explored using multivariable modeling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Median age was 50 years, and 93% were male. At baseline 30% had FLD. With control for lipid-lowering medications and body mass index, low-density lipoprotein (LDL) cholesterol (LDL-C), LDL particle concentration (LDL-P), and apolipoprotein B (apoB) decreased and adiponectin increased over time (all P &amp;lt; .05); On follow-up (vs baseline), there was no significant difference in FLD category (P = .85); 60% remained without FLD, 17% had unchanged, 12% worsening, and 12% improved FLD. Baseline low-density lipoproteins (LDL-C, LDL-P, small LDL-P) and apoB appeared highest in those with unchanged FLD status (all P &amp;lt; .05). No associations between changes in FLD across follow-up (worsening\/improvement vs unchanged) and lipid\/lipoproteins changes were identified.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this cohort, there was no significant change in FLD prevalence over a relatively short timeframe. Baseline atherogenic lipids appeared highest in those with persistent steatosis or steatohepatitis, suggesting potentially increased cardiovascular risk in this group, but an independent relationship between individual-level change in FLD status and lipid\/lipoprotein levels across follow-up was not observed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab764","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:37:45Z","timestamp":1631101065000},"page":"1914-1924","source":"Crossref","is-referenced-by-count":1,"title":["Evolution of Fatty Liver Disease and Relationship With Lipoproteins and Clinical Outcomes in Hepatitis B\/Human Immunodeficiency Virus Coinfection"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-9139","authenticated-orcid":false,"given":"Mandana","family":"Khalili","sequence":"first","affiliation":[{"name":"University of California, San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy C","family":"King","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health , Pittsburgh, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E","family":"Kleiner","sequence":"additional","affiliation":[{"name":"National Institutes of Health , Bethesda, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond T","family":"Chung","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital , Boston, Massachusetts, USA"},{"name":"Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul K","family":"Bhan","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital , Boston, Massachusetts, USA"},{"name":"Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc G","family":"Ghany","sequence":"additional","affiliation":[{"name":"National Institutes of Health , Bethesda, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S","family":"Sulkowski","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Lisker-Melman","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine and John Cochran Veterans Affairs Medical Center , St Louis , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamta K","family":"Jain","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center , Dallas, Texas , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry L A","family":"Janssen","sequence":"additional","affiliation":[{"name":"University Health Network , Toronto, Ontario , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda S","family":"Hinerman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Graduate School of Public Health , Pittsburgh, Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun J","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University , Richmond, Virginia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K","family":"Sterling","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University , Richmond, Virginia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"author":"Joint United Nations Programme on 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with HIV and hepatitis B coinfection [manuscript published online ahead of print 1 September 2020]","author":"Khalili","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2022110307180561900_CIT0009","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/hep.26741","article-title":"Fibrosis progression in human immunodeficiency virus\/hepatitis C virus coinfected adults: prospective analysis of 435 liver biopsy pairs","volume":"59","author":"Konerman","year":"2014","journal-title":"Hepatology"},{"key":"2022110307180561900_CIT0010","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41395-018-0409-9","article-title":"Spectrum of liver disease in hepatitis B virus (HBV) patients co-infected with human immunodeficiency virus (HIV): results of the HBV-HIV cohort study","volume":"114","author":"Sterling","year":"2019","journal-title":"Am J 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