{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:19:53Z","timestamp":1790399993094,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"Supplement_4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["16\/136\/111"],"award-info":[{"award-number":["16\/136\/111"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000278","name":"Department for International Development, UK Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Klebsiella pneumoniae is a World Health Organization high-priority antibiotic-resistant pathogen. However, little is known about Klebsiella lineages circulating in Nigeria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed whole-genome sequencing (WGS) of 141 Klebsiella isolated between 2016 and 2018 from clinical specimens at 3 antimicrobial-resistance (AMR) sentinel surveillance tertiary hospitals in southwestern Nigeria. We conducted in silico multilocus sequence typing; AMR gene, virulence gene, plasmid, and K and O loci profiling; as well as phylogenetic analyses, using publicly available tools and Nextflow pipelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Phylogenetic analysis revealed that the majority of the 134 K. pneumoniae and 5 K. quasipneumoniae isolates from Nigeria characterized are closely related to globally disseminated multidrug-resistant clones. Of the 39 K. pneumoniae sequence types (STs) identified, the most common were ST307 (15%), ST5241 (12%), ST15 (~9%), and ST25 (~6%). ST5241, 1 of 10 novel STs detected, is a single locus variant of ST636 carrying dfrA14, tetD, qnrS, and oqxAB resistance genes. The extended-spectrum \u03b2-lactamase (ESBL) gene blaCTX_M-15 was seen in 72% of K. pneumoniae genomes, while 8% encoded a carbapenemase. No isolate carried a combination of carbapenemase-producing genes. Four likely outbreak clusters from 1 facility, within STs 17, 25, 307, and 5241, were ESBL but not carbapenemase-bearing clones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study uncovered known and novel K. pneumoniae lineages circulating in 3 hospitals in Southwest Nigeria that include multidrug-resistant ESBL producers. Carbapenemase-producing isolates remain uncommon. WGS retrospectively identified outbreak clusters, pointing to the value of genomic approaches in AMR surveillance for improving infection prevention and control in Nigerian hospitals.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cid\/ciab769","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T20:02:12Z","timestamp":1632945732000},"page":"S308-S315","source":"Crossref","is-referenced-by-count":46,"title":["Clones and Clusters of Antimicrobial-Resistant<i>Klebsiella<\/i>From Southwestern Nigeria"],"prefix":"10.1093","volume":"73","author":[{"given":"Ayorinde O","family":"Afolayan","sequence":"first","affiliation":[{"name":"Global Health Research \u00a0Unit on Genomic Surveillance of Antimicrobial Resistance, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson O","family":"Oaikhena","sequence":"additional","affiliation":[{"name":"Global Health Research \u00a0Unit on Genomic Surveillance of Antimicrobial Resistance, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron O","family":"Aboderin","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olatunde F","family":"Olabisi","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adewale A","family":"Amupitan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyekola V","family":"Abiri","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica O","family":"Ogunleye","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, University College Hospital, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkison Ewomazino","family":"Odih","sequence":"additional","affiliation":[{"name":"Global Health Research \u00a0Unit on Genomic Surveillance of Antimicrobial Resistance, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolaji T","family":"Adeyemo","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Osun State University Teaching Hospital, \u00a0Teaching Hospital, Osogbo, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeyemi T","family":"Adeyemo","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope O","family":"Obadare","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Abrudan","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom"},{"name":"Wellcome Genome Campus, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Argim\u00f3n","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom"},{"name":"Wellcome Genome Campus, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"David","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom"},{"name":"Wellcome Genome Campus, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir","family":"Kekre","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom"},{"name":"Wellcome Genome Campus, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Underwood","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom"},{"name":"Wellcome Genome Campus, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiodun","family":"Egwuenu","sequence":"additional","affiliation":[{"name":"Nigeria Centre for Disease Control, Jabi, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikwe","family":"Ihekweazu","sequence":"additional","affiliation":[{"name":"Nigeria Centre for Disease Control, Jabi, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Aanensen","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iruka N","family":"Okeke","sequence":"additional","affiliation":[{"name":"Global Health Research \u00a0Unit on Genomic Surveillance of Antimicrobial Resistance, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NIHR Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Abudahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Harste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Muddyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Donado-Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Fabian Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Arevalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fernanda Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C D","family":"Osma Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Ravikumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Nagaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Shamanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Govindan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshata","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Sravani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R","family":"Shincy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffimole","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K N","family":"Ravishankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolaade J","family":"Ajiboye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta L","family":"Lagrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polle Krystle V","family":"Macaranas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnettah M","family":"Olorosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June M","family":"Gayeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmer M","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Stelling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Vegvari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"2021120111083460900_CIT0001","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1128\/CMR.11.4.589","article-title":"Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors","volume":"11","author":"Podschun","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"2021120111083460900_CIT0002","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.tim.2016.09.007","article-title":"Klebsiella pneumoniae population genomics and antimicrobial-resistant clones","volume":"24","author":"Wyres","year":"2016","journal-title":"Trends Microbiol"},{"key":"2021120111083460900_CIT0003","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13073-019-0706-y","article-title":"Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia","volume":"12","author":"Wyres","year":"2020","journal-title":"Genome Med"},{"key":"2021120111083460900_CIT0004","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jgar.2019.09.007","article-title":"High proportion of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae among extended-spectrum \u03b2-lactamase-producers in Nigerian hospitals","volume":"21","author":"Olalekan","year":"2020","journal-title":"J Glob Antimicrob Resist"},{"key":"2021120111083460900_CIT0005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ijid.2019.11.024","article-title":"High prevalence of ESBL-producing Klebsiella pneumoniae in clinical samples from central C\u00f4te d\u2019Ivoire","volume":"91","author":"M\u00fcller-Schulte","year":"2020","journal-title":"Int J Infect Dis"},{"key":"2021120111083460900_CIT0006","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S1473-3099(17)30394-8","article-title":"Trends in antimicrobial resistance in bloodstream infection isolates at a large urban hospital in Malawi (1998\u20132016): a surveillance study","volume":"17","author":"Musicha","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2021120111083460900_CIT0007","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/S2666-5247(20)30061-6","article-title":"Investigation of sequential outbreaks of Burkholderia cepacia and multidrug-resistant extended spectrum \u03b2-lactamase producing Klebsiella species in a West African tertiary hospital neonatal unit: a retrospective genomic analysis","volume":"1","author":"Okomo","year":"2020","journal-title":"Lancet Microbe"},{"key":"2021120111083460900_CIT0008","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/s41598-020-58012-8","article-title":"Pathogenomics and evolutionary epidemiology of multi-drug resistant clinical klebsiella pneumoniae isolated from Pretoria, South Africa","volume":"10","author":"Mbelle","year":"2020","journal-title":"Sci Rep"},{"key":"2021120111083460900_CIT0009","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00685-18","article-title":"Emergence of New Delhi Metallo-\u03b2-Lactamase (NDM-5) in Klebsiella quasipneumoniae from Neonates in a Nigerian Hospital","volume":"4","author":"Brinkac","year":"2019","journal-title":"mSphere"},{"key":"2021120111083460900_CIT0010","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2471\/BLT.11.088179","article-title":"Health-care-associated infection in Africa: a systematic review","volume":"89","author":"Bagheri Nejad","year":"2011","journal-title":"Bull World Health Organ"},{"key":"2021120111083460900_CIT0011","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4102\/ajlm.v7i2.796","article-title":"A systematic review of healthcare-associated infections in Africa: an antimicrobial resistance perspective","volume":"7","author":"Irek","year":"2018","journal-title":"Afr J Lab Med"},{"key":"2021120111083460900_CIT0012","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s41564-019-0492-8","article-title":"Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread","volume":"4","author":"David","year":"2019","journal-title":"Nat Microbiol"},{"key":"2021120111083460900_CIT0013","first-page":"mgen000349","article-title":"Whole-genome sequencing resolves a polyclonal outbreak by extended-spectrum beta-lactam and carbapenem-resistant Klebsiella pneumoniae in a Portuguese tertiary-care hospital","volume":"7","author":"Perdig\u00e3o","year":"2020","journal-title":"Microb Genomics"},{"key":"2021120111083460900_CIT0014","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/jac\/dkz032","article-title":"Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages","volume":"74","author":"Musicha","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"2021120111083460900_CIT0015","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s10096-018-3324-5","article-title":"Molecular epidemiology of virulence and antimicrobial resistance determinants in Klebsiella pneumoniae from hospitalised patients in Kilimanjaro, Tanzania","volume":"37","author":"Sonda","year":"2018","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2021120111083460900_CIT0016","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1093\/jac\/dkaa107","article-title":"Characterization of Klebsiella pneumoniae isolates from a mother-child cohort in Madagascar","volume":"75","author":"Rakotondrasoa","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"2021120111083460900_CIT0017","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciab784","article-title":"Rapid genomic characterization and global surveillance of Klebsiella using pathogenwatch","volume":"73","author":"Argim\u00f3n","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2021120111083460900_CIT0018","author":"Nigeria Centre for Disease Control (NCDC).","year":"2017"},{"key":"2021120111083460900_CIT0019","first-page":"1","author":"Nigeria","year":"2019"},{"key":"2021120111083460900_CIT0020","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3201\/eid0102.950209","article-title":"WHONET: an information system for monitoring antimicrobial resistance","volume":"1","author":"O\u2019Brien","year":"1995","journal-title":"Emerg Infect Dis"},{"key":"2021120111083460900_CIT0021","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"2021120111083460900_CIT0022","author":"Clinical and Laboratory Standards Institute.","year":"2020"},{"key":"2021120111083460900_CIT0023","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13073-018-0587-5","article-title":"Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae","volume":"10","author":"Lam","year":"2018","journal-title":"Genome Med"},{"key":"2021120111083460900_CIT0024","doi-asserted-by":"crossref","first-page":"e000196","DOI":"10.1099\/mgen.0.000196","article-title":"Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations","volume":"4","author":"Lam","year":"2018","journal-title":"Microb Genomics"},{"key":"2021120111083460900_CIT0025","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1128\/JCM.43.8.4178-4182.2005","article-title":"Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates","volume":"43","author":"Diancourt","year":"2005","journal-title":"J Clin Microbiol"},{"key":"2021120111083460900_CIT0026","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02318","article-title":"CTX-M-15-producing E. coli isolates from food products in Germany are mainly associated with an IncF-type plasmid and belong to two predominant clonal E. coli lineages","volume":"8","author":"Irrgang","year":"2017","journal-title":"Front Microbiol"},{"key":"2021120111083460900_CIT0027","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.diagmicrobio.2015.12.010","article-title":"blaCTX-M-15 carried by IncF-type plasmids is the dominant ESBL gene in Escherichia coli and Klebsiella pneumoniae at a hospital in Ghana","volume":"84","author":"Agyekum","year":"2016","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2021120111083460900_CIT0028","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/infdis\/jiw282","article-title":"The epidemiology of carbapenem-resistant enterobacteriaceae: the impact and evolution of a global menace","volume":"215","author":"Logan","year":"2017","journal-title":"J Infect Dis"},{"key":"2021120111083460900_CIT0029","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1128\/JCM.43.3.1448-1450.2005","article-title":"Erroneous reporting of coagulase-negative Staphylococci as Kocuria spp. by the Vitek 2 system","volume":"43","author":"Ben-Ami","year":"2005","journal-title":"J Clin Microbiol"},{"key":"2021120111083460900_CIT0030","article-title":"The brief case: Klebsiella variicola-identifying the misidentified","volume":"57","author":"Fontana","year":"2019","journal-title":"J Clin Microbiol"},{"key":"2021120111083460900_CIT0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004982","article-title":"Virulent clones of Klebsiella pneumoniae: Identification and evolutionary scenario based on genomic and phenotypic characterization","volume":"4","author":"Brisse","year":"2009","journal-title":"PLoS One"},{"key":"2021120111083460900_CIT0032","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3201\/eid2011.140206","article-title":"Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups","volume":"20","author":"Bialek-Davenet","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"2021120111083460900_CIT0033","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.01249","article-title":"The diversity of lipopolysaccharide (O) and capsular polysaccharide (K) antigens of invasive Klebsiella pneumoniae in a multi-country collection","volume":"11","author":"Choi","year":"2020","journal-title":"Front Microbiol"},{"key":"2021120111083460900_CIT0034","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciab777","article-title":"Complexity of genomic epidemiology of carbapenem-resistant klebsiella pneumoniae isolates in Colombia urges the reinforcement of whole genome sequencing-based surveillance programs","volume":"73","author":"Saavedra","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2021120111083460900_CIT0035","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciab767","article-title":"High-resolution genomic profiling of carbapenem-resistant Klebsiella pneumoniae isolates: a multicentric retrospective Indian study","volume":"73","author":"Nagaraj","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2021120111083460900_CIT0036","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.cmi.2014.08.022","article-title":"Is the monoclonal spread of the ST258, KPC-3-producing clone being replaced in southern Italy by the dissemination of multiple clones of carbapenem-non-susceptible, KPC-3-producing Klebsiella pneumoniae?","volume":"21","author":"Geraci","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"2021120111083460900_CIT0037","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2020.25.20.2000627","article-title":"Cross-border spread of blaNDM-1- And blaOXA-48 positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019","volume":"25","author":"Ludden","year":"2020","journal-title":"Eurosurveillance"},{"key":"2021120111083460900_CIT0038","doi-asserted-by":"crossref","first-page":"104507","DOI":"10.1016\/j.micpath.2020.104507","article-title":"Molecular characterization of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae ST11 harbouring blaNDM-1 and blaOXA-48 carbapenemases in Iran","volume":"149","author":"Solgi","year":"2020","journal-title":"Microb Pathog"},{"key":"2021120111083460900_CIT0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2020.07.019","article-title":"Antibiotics interfere with the evolution of plasmid stability","volume":"30","author":"Wein","year":"2020","journal-title":"Curr Biol"},{"key":"2021120111083460900_CIT0040","first-page":"e000110","article-title":"Diversity, virulence, and antimicrobial resistance of the KPC-producing Klebsiella pneumoniae ST307 clone","volume":"3","author":"Villa","year":"2017","journal-title":"Microb Genom"},{"key":"2021120111083460900_CIT0041","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1128\/AAC.01775-15","article-title":"A two-year surveillance in five Colombian tertiary care hospitals reveals high frequency of non-CG258 clones of carbapenem-resistant klebsiella pneumoniae with distinct clinical characteristics","volume":"60","author":"Ocampo","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083460900_CIT0042","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/mdr.2012.0238","article-title":"Rapid expansion of KPC-2-producing Klebsiella pneumoniae isolates in two Texas hospitals due to clonal spread of ST258 and ST307 lineages","volume":"19","author":"Castanheira","year":"2013","journal-title":"Microb Drug Resist"},{"key":"2021120111083460900_CIT0043","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00489-17","article-title":"Population genomic analysis of 1,777 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates, Houston, Texas: unexpected abundance of clonal group 307","volume":"8","author":"Long","year":"2017","journal-title":"mBio"},{"key":"2021120111083460900_CIT0044","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3201\/eid2504.181482","article-title":"Klebsiella pneumoniae ST307 with blaOXA-181, South Africa, 2014\u20132016","volume":"25","author":"Lowe","year":"2019","journal-title":"Emerg Infect Dis"},{"key":"2021120111083460900_CIT0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-16322-5","article-title":"Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines","volume":"11","author":"Argim\u00f3n","year":"2020","journal-title":"Nat Commun"},{"key":"2021120111083460900_CIT0046","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciab776","article-title":"Genome sequencing identifies previously unrecognized Klebsiella pneumoniae outbreaks in neonatal intensive care units in the Philippines","volume":"73","author":"Carlos","year":"2021","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/73\/Supplement_4\/S308\/41394881\/ciab769.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/73\/Supplement_4\/S308\/41394881\/ciab769.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T19:34:17Z","timestamp":1673379257000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/73\/Supplement_4\/S308\/6447011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":46,"journal-issue":{"issue":"Supplement_4","published-online":{"date-parts":[[2021,12,1]]},"published-print":{"date-parts":[[2021,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciab769","relation":{},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,12,1]]}}}