{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:06:30Z","timestamp":1792188390202,"version":"4.4.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"Supplement_4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["136\/111"],"award-info":[{"award-number":["136\/111"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an emerging public health problem. This study explores the specifics of CRKP epidemiology in Colombia based on whole genome sequencing (WGS) of the National Reference Laboratory at Instituto Nacional de Salud (INS)\u2019s 2013\u20132017 sample collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 425 CRKP isolates from 21 departments were analyzed by HiSeq-X10\u00aeIllumina high-throughput sequencing. Bioinformatic analysis was performed, primarily using the pipelines developed collaboratively by the National Institute for Health Research Global Health Research Unit (GHRU) on Genomic Surveillance of Antimicrobial Resistance (AMR), and AGROSAVIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 425 CRKP isolates, 91.5% were carbapenemase-producing strains. The data support a recent expansion and the endemicity of CRKP in Colombia with the circulation of 7 high-risk clones, the most frequent being CG258 (48.39% of isolates). We identified genes encoding carbapenemases blaKPC-3, blaKPC-2, blaNDM-1, blaNDM-9, blaVIM-2, blaVIM-4, and blaVIM-24, and various mobile genetic elements (MGE). The virulence of CRKP isolates was low, but colibactin (clb3) was present in 25.2% of isolates, and a hypervirulent CRKP clone (CG380) was reported for the first time in Colombia. ST258, ST512, and ST4851 were characterized by low levels of diversity in the core genome (ANI &amp;gt; 99.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study outlines complex CRKP epidemiology in Colombia. CG258 expanded clonally and carries specific carbapenemases in specific MGEs, while the other high-risk clones (CG147, CG307, and CG152) present a more diverse complement of carbapenemases. The specifics of the Colombian situation stress the importance of WGS-based surveillance to monitor evolutionary trends of sequence types (STs), MGE, and resistance and virulence genes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciab777","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T09:53:07Z","timestamp":1632390787000},"page":"S290-S299","source":"Crossref","is-referenced-by-count":44,"title":["Complexity of Genomic Epidemiology of Carbapenem-Resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    Isolates in Colombia Urges the Reinforcement of Whole Genome Sequencing-Based Surveillance Programs"],"prefix":"10.1093","volume":"73","author":[{"given":"Sandra Yamile","family":"Saavedra","sequence":"first","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud (INS), Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan Fabian","family":"Bernal","sequence":"additional","affiliation":[{"name":"Colombian Integrated Program for Antimicrobial Resistance Surveillance (COIPARS), CI Tibaitat\u00e1, Corporaci\u00f3n Colombiana de Investigaci\u00f3n Agropecuaria (AGROSAVIA), Tibaitat\u00e1 \u2013 Mosquera, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efra\u00edn","family":"Montilla-Escudero","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud (INS), Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefany Alejandra","family":"Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"Colombian Integrated Program for Antimicrobial Resistance Surveillance (COIPARS), CI Tibaitat\u00e1, Corporaci\u00f3n Colombiana de Investigaci\u00f3n Agropecuaria (AGROSAVIA), Tibaitat\u00e1 \u2013 Mosquera, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Andr\u00e9s","family":"Prada","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Direcci\u00f3n de Investigaci\u00f3n en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Fernanda","family":"Valencia","sequence":"additional","affiliation":[{"name":"Colombian Integrated Program for Antimicrobial Resistance Surveillance (COIPARS), CI Tibaitat\u00e1, Corporaci\u00f3n Colombiana de Investigaci\u00f3n Agropecuaria (AGROSAVIA), Tibaitat\u00e1 \u2013 Mosquera, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Moreno","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud (INS), Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Melissa","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud (INS), Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela Sof\u00eda","family":"Garc\u00eda-Vega","sequence":"additional","affiliation":[{"name":"Colombian Integrated Program for Antimicrobial Resistance Surveillance (COIPARS), CI Tibaitat\u00e1, Corporaci\u00f3n Colombiana de Investigaci\u00f3n Agropecuaria (AGROSAVIA), Tibaitat\u00e1 \u2013 Mosquera, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Abrudan","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, UK"},{"name":"Wellcome Genome Campus, Hinxton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Argim\u00f3n","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, UK"},{"name":"Wellcome Genome Campus, Hinxton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir","family":"Kekre","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, UK"},{"name":"Wellcome Genome Campus, Hinxton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Underwood","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, UK"},{"name":"Wellcome Genome Campus, Hinxton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Aanensen","sequence":"additional","affiliation":[{"name":"Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, UK"},{"name":"Wellcome Genome Campus, Hinxton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Duarte","sequence":"additional","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud (INS), Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Donado-Godoy","sequence":"additional","affiliation":[{"name":"Colombian Integrated Program for Antimicrobial Resistance Surveillance (COIPARS), CI Tibaitat\u00e1, Corporaci\u00f3n Colombiana de Investigaci\u00f3n Agropecuaria (AGROSAVIA), Tibaitat\u00e1 \u2013 Mosquera, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NIHR Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Abudahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Harste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Muddyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Delgadillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C D","family":"Osma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Ravikumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Nagaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Shamanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Govindan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshata","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Sravani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R","family":"Shincy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffimole","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K N","family":"Ravishankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iruka N","family":"Okeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson O","family":"Oaikhena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayorinde O","family":"Afolayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolaade J","family":"Ajiboye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkison","family":"Ewomazino Odih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta L","family":"Lagrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polle Krystle V","family":"Macaranas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnettah M","family":"Olorosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June M","family":"Gayeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmer M","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Stelling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Vegvari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"2021120111083979500_CIT0001","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/femsre\/fuy043","article-title":"Klebsiella pneumoniae infection biology: living to counteract host defences","volume":"43","author":"Bengoechea","year":"2018","journal-title":"FEMS Microbiol Rev"},{"key":"2021120111083979500_CIT0002","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms7050138","article-title":"Community- and hospital-acquired Klebsiella pneumoniae urinary tract infections in Portugal: virulence and antibiotic resistance","volume":"7","author":"Caneiras","year":"2019","journal-title":"Microorganisms"},{"key":"2021120111083979500_CIT0003","author":"WHO","year":"2017"},{"key":"2021120111083979500_CIT0004","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.tig.2014.07.003","article-title":"Whole-genome sequencing to control antimicrobial resistance","volume":"30","author":"K\u00f6ser","year":"2014","journal-title":"Trends Genet"},{"key":"2021120111083979500_CIT0005","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/infdis\/jix524","article-title":"An analysis of the epidemic of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: convergence of two evolutionary mechanisms creates the \u201cperfect storm\u201d","volume":"217","author":"Rojas","year":"2017","journal-title":"J Infect Dis"},{"key":"2021120111083979500_CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-16322-5","article-title":"Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines","volume":"11","author":"Argim\u00f3n","year":"2020","journal-title":"Nat Commun"},{"key":"2021120111083979500_CIT0007","volume-title":"Consumo de antibioticos en el \u00e1mbito hospitalario","author":"Gomez Rubio","year":"2017"},{"key":"2021120111083979500_CIT0008","volume-title":"Antimicrobial consumption in the EU\/ EEA Annual Epidemiological Report for 2019 Key facts","author":"European Centre for Disease Prevention and Control","year":"2020"},{"key":"2021120111083979500_CIT0009","author":"INS","year":"2016"},{"key":"2021120111083979500_CIT0010","author":"INS","year":"2017"},{"key":"2021120111083979500_CIT0011","author":"INS","year":"2018"},{"key":"2021120111083979500_CIT0012","doi-asserted-by":"crossref","first-page":"473","DOI":"10.7705\/biomedica.v37i4.3432","article-title":"Results of the national surveillance of antimicrobial resistance of Enterobacteriaceae and gram negative bacilli in health care-associated infections in Colombia, 2012-2014","volume":"37","author":"Ovalle","year":"2017","journal-title":"Biomedica"},{"key":"2021120111083979500_CIT0013","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1128\/AAC.00186-06","article-title":"First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America","volume":"50","author":"Villegas","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083979500_CIT0014","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1469-0691.2010.03209.x","article-title":"Intercontinental spread from Israel to Colombia of a KPC-3-producing Klebsiella pneumoniae strain","volume":"17","author":"Lopez","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"2021120111083979500_CIT0015","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1473-3099(13)70190-7","article-title":"Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases","volume":"13","author":"Munoz-Price","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"2021120111083979500_CIT0016","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1128\/AAC.01775-15","article-title":"A two-year surveillance in five Colombian tertiary care hospitals reveals high frequency of non-CG258 clones of carbapenem-resistant Klebsiella pneumoniae with distinct clinical characteristics","volume":"60","author":"Ocampo","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083979500_CIT0017","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1128\/AAC.01208-10","article-title":"Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia","volume":"55","author":"Montealegre","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083979500_CIT0018","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1128\/AAC.01447-12","article-title":"Outbreak of NDM-1-producing Klebsiella pneumoniae in a neonatal unit in Colombia","volume":"57","author":"Escobar P\u00e9rez","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083979500_CIT0019","author":"Underwood"},{"key":"2021120111083979500_CIT0020","doi-asserted-by":"crossref","DOI":"10.1101\/2020.12.14.422303","article-title":"Genomic surveillance framework and global population structure for Klebsiella pneumoniae","volume-title":"bioRxiv","author":"Lam","year":"2020"},{"key":"2021120111083979500_CIT0021","first-page":"e000102","article-title":"Identification of Klebsiella capsule synthesis loci from whole genome data","volume":"2","author":"Wyres","year":"2016","journal-title":"Microb Genom"},{"key":"2021120111083979500_CIT0022","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/molbev\/msu300","article-title":"IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies","volume":"32","author":"Nguyen","year":"2015","journal-title":"Mol Biol Evol"},{"key":"2021120111083979500_CIT0023","first-page":"e000093","article-title":"Microreact: visualizing and sharing data for genomic epidemiology and phylogeography","volume":"2","author":"Argim\u00f3n","year":"2016","journal-title":"Microb Genom"},{"key":"2021120111083979500_CIT0024","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.tim.2014.09.003","article-title":"Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding","volume":"22","author":"Chen","year":"2014","journal-title":"Trends Microbiol"},{"key":"2021120111083979500_CIT0025","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1128\/AAC.01019-15","article-title":"Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance","volume":"59","author":"Pitout","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083979500_CIT0026","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1186\/s12879-019-4461-x","article-title":"Risk factors and survival of patients infected with carbapenem-resistant Klebsiella pneumoniae in a KPC endemic setting: a case-control and cohort study","volume":"19","author":"Cienfuegos-Gallet","year":"2019","journal-title":"BMC Infect Dis"},{"key":"2021120111083979500_CIT0027","doi-asserted-by":"crossref","first-page":"126551","DOI":"10.1016\/j.micres.2020.126551","article-title":"Phenotypical and molecular assessment of the virulence potential of KPC-3-producing Klebsiella pneumoniae ST392 clinical isolates","volume":"240","author":"D\u2019Apolito","year":"2020","journal-title":"Microbiol Res"},{"key":"2021120111083979500_CIT0028","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1128\/AAC.03072-15","article-title":"Initial assessment of the molecular epidemiology of blaNDM-1 in Colombia","volume":"60","author":"Rojas","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083979500_CIT0029","doi-asserted-by":"crossref","first-page":"e01148","DOI":"10.1128\/AAC.01148-20","article-title":"Emerging antimicrobial resistant high-risk clones among Klebsiella pneumoniae: ST307 and ST147","volume":"64","author":"Peirano","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083979500_CIT0030","first-page":"211","article-title":"First characterization of K. pneumoniae ST11 clinical isolates harboring blaKPC-3 in Latin America","volume":"52","author":"Garcia-Fulgueiras","year":"2020","journal-title":"Rev Argent Microbiol"},{"key":"2021120111083979500_CIT0031","article-title":"Diversity, virulence, and antimicrobial resistance of the KPC-producing Klebsiella pneumoniae ST307 clone","volume":"3","author":"Villa","year":"2017","journal-title":"Microb Genom"},{"key":"2021120111083979500_CIT0032","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/femsre\/fux013","article-title":"Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance","volume":"41","author":"Navon-Venezia","year":"2017","journal-title":"FEMS Microbiol Rev"},{"key":"2021120111083979500_CIT0033","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1128\/AAC.00126-09","article-title":"Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258","volume":"53","author":"Kitchel","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083979500_CIT0034","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/cid\/cir025","article-title":"Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention","volume":"52","author":"Schwaber","year":"2011","journal-title":"Clin Infect Dis"},{"key":"2021120111083979500_CIT0035","author":"Pathogenwatch"},{"key":"2021120111083979500_CIT0036","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jac\/dkq431","article-title":"ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China","volume":"66","author":"Qi","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"2021120111083979500_CIT0037","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3201\/eid2602.190594","article-title":"Novel subclone of carbapenem-resistant Klebsiella pneumoniae sequence type 11 with enhanced virulence and transmissibility, China","volume":"26","author":"Zhou","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"2021120111083979500_CIT0038","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/jac\/dks396","article-title":"Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340)","volume":"68","author":"Pereira","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"2021120111083979500_CIT0039","author":"Pathogenwatch"},{"key":"2021120111083979500_CIT0040","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s41564-019-0492-8","article-title":"Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread","volume":"4","author":"David","year":"2019","journal-title":"Nat Microbiol"},{"key":"2021120111083979500_CIT0041","author":"Pathogenwatch"},{"key":"2021120111083979500_CIT0042","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1093\/jac\/dkx148","article-title":"Genomic epidemiology of global VIM-producing Enterobacteriaceae","volume":"72","author":"Matsumura","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"2021120111083979500_CIT0043","doi-asserted-by":"crossref","first-page":"25043","DOI":"10.1073\/pnas.2003407117","article-title":"Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae","volume":"117","author":"David","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021120111083979500_CIT0044","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00115-18","article-title":"NDM metallo-\u03b2-lactamases and their bacterial producers in health care settings","volume":"32","author":"Wu","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"2021120111083979500_CIT0045","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1128\/AAC.03926-14","article-title":"Dissemination of high-risk clones of extensively drug-resistant Pseudomonas aeruginosa in Colombia","volume":"59","author":"Correa","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2021120111083979500_CIT0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.102599","article-title":"The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings","volume":"51","author":"Gao","year":"2020","journal-title":"EBioMedicine"},{"key":"2021120111083979500_CIT0047","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11756-y","article-title":"OmpK36-mediated carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo","volume":"10","author":"Wong","year":"2019","journal-title":"Nat Commun"},{"key":"2021120111083979500_CIT0048","doi-asserted-by":"crossref","first-page":"e1008114","DOI":"10.1371\/journal.pgen.1008114","article-title":"Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae","volume":"15","author":"Wyres","year":"2019","journal-title":"PLoS Genet"},{"key":"2021120111083979500_CIT0049","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13073-018-0587-5","article-title":"Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae","volume":"10","author":"Lam","year":"2018","journal-title":"Genome Med"},{"key":"2021120111083979500_CIT0050","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41579-019-0315-1","article-title":"Population genomics of Klebsiella pneumoniae","volume":"18","author":"Wyres","year":"2020","journal-title":"Nat Rev Microbiol"},{"key":"2021120111083979500_CIT0051","doi-asserted-by":"crossref","first-page":"e23364","DOI":"10.1002\/jcla.23364","article-title":"Prevalence and characteristics of surgical site hypervirulent Klebsiella pneumoniae isolates","volume":"34","author":"Zhao","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"2021120111083979500_CIT0052","first-page":"e000196","article-title":"Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations","volume":"4","author":"Lam","year":"2018","journal-title":"Microb Genom"},{"key":"2021120111083979500_CIT0053","doi-asserted-by":"crossref","first-page":"ofaa266","DOI":"10.1093\/ofid\/ofaa266","article-title":"Whole genome sequencing of Peruvian Klebsiella pneumoniae identifies novel plasmid vectors bearing carbapenem resistance gene NDM-1","volume":"7","author":"Roach","year":"2020","journal-title":"Open Forum Infect Dis"},{"key":"2021120111083979500_CIT0054","doi-asserted-by":"crossref","first-page":"6736897","DOI":"10.1155\/2019\/6736897","article-title":"Cooccurrence of NDM-1, ESBL, RmtC, AAC(6\u2019)-Ib, and QnrB in clonally related Klebsiella pneumoniae isolates together with coexistence of CMY-4 and AAC(6\u2032)-Ib in Enterobacter cloacae isolates from Saudi Arabia","volume":"2019","author":"Al-Agamy","year":"2019","journal-title":"Biomed Res Int"}],"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/73\/Supplement_4\/S290\/41394865\/ciab777.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/73\/Supplement_4\/S290\/41394865\/ciab777.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T10:41:56Z","timestamp":1638355316000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/73\/Supplement_4\/S290\/6447009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,25]]},"references-count":54,"journal-issue":{"issue":"Supplement_4","published-online":{"date-parts":[[2021,11,25]]},"published-print":{"date-parts":[[2021,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cid\/ciab777","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.21.449250","asserted-by":"object"}]},"ISSN":["1058-4838","1537-6591"],"issn-type":[{"value":"1058-4838","type":"print"},{"value":"1537-6591","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,11,25]]}}}