{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:36:23Z","timestamp":1772138183483,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"ANID\u2014Millennium Science Initiative Program","award":["ICN09_016"],"award-info":[{"award-number":["ICN09_016"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["75N93019C00001"],"award-info":[{"award-number":["75N93019C00001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["75N9301900065"],"award-info":[{"award-number":["75N9301900065"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Innovation Fund for Competitiveness FIC-R 2017","award":["BIP Code: 30488811\u20130"],"award-info":[{"award-number":["BIP Code: 30488811\u20130"]}]},{"DOI":"10.13039\/501100002850","name":"FONDECYT","doi-asserted-by":"publisher","award":["N\u00ba\u00a01190156"],"award-info":[{"award-number":["N\u00ba\u00a01190156"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"FONDECYT","doi-asserted-by":"publisher","award":["N\u00ba 1180798"],"award-info":[{"award-number":["N\u00ba 1180798"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The development of effective vaccines against coronavirus disease 2019 is a global priority. CoronaVac is an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine with promising safety and immunogenicity profiles. This article reports safety and immunogenicity results obtained for healthy Chilean adults aged \u226518 years in a phase 3 clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Volunteers randomly received 2 doses of CoronaVac or placebo, separated by 2 weeks. A total of 434 volunteers were enrolled, 397 aged 18\u201359 years and 37 aged \u226560 years. Solicited and unsolicited adverse reactions were registered from all volunteers. Blood samples were obtained from a subset of volunteers and analyzed for humoral and cellular measures of immunogenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The primary adverse reaction in the 434 volunteers was pain at the injection site, with a higher incidence in the vaccine than in the placebo arm. Adverse reactions observed were mostly mild and local. No severe adverse events were reported. The humoral evaluation was performed on 81 volunteers. Seroconversion rates for specific anti-S1-receptor binding domain (RBD) immunoglobulin G (IgG) were 82.22% and 84.44% in the 18\u201359 year age group and 62.69% and 70.37% in the \u226560 year age group, 2 and 4 weeks after the second dose, respectively. A significant increase in circulating neutralizing antibodies was detected 2 and 4 weeks after the second dose. The cellular evaluation was performed on 47 volunteers. We detected a significant induction of T-cell responses characterized by the secretion of interferon-\u03b3 (IFN-\u03b3) upon stimulation with Mega Pools of peptides from SARS-CoV-2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Immunization with CoronaVac in a 0\u201314 schedule in Chilean adults aged \u226518 years is safe, induces anti-S1-RBD IgG with neutralizing capacity, activates T cells, and promotes the secretion of IFN-\u03b3 upon stimulation with SARS-CoV-2 antigens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cid\/ciab823","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T15:20:46Z","timestamp":1631719246000},"page":"e792-e804","source":"Crossref","is-referenced-by-count":81,"title":["Safety and Immunogenicity of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Subgroup of Healthy Adults in Chile"],"prefix":"10.1093","volume":"75","author":[{"given":"Susan M","family":"Bueno","sequence":"first","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy , Santiago , Chile"},{"name":"Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Abarca","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy , Santiago , Chile"},{"name":"Departamento de Enfermedades Infecciosas e Inmunolog\u00eda Pedi\u00e1trica, Divisi\u00f3n de Pediatr\u00eda, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo A","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy , Santiago , Chile"},{"name":"Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s M S","family":"G\u00e1lvez","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy , Santiago , Chile"},{"name":"Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A","family":"Soto","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy , Santiago , Chile"},{"name":"Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa F","family":"Duarte","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy , Santiago , Chile"},{"name":"Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara M","family":"Schultz","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy , Santiago , Chile"},{"name":"Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaspar A","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy , Santiago , 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