{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:42:08Z","timestamp":1764225728513},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"Supplement_5","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Complete diagnostic autopsy (CDA) is considered to be the gold-standard procedure that aids in determination of cause of death in stillbirths and neonatal deaths. However, CDA is not routinely practiced in South Asian countries due to religious beliefs, lack of expertise, and lack of resources. Minimally invasive tissue sampling (MITS) has been recommended as a less mutilating and less expensive alternative to CDA for obtaining tissues for analysis. The present study aims to evaluate the yield of lung tissue and histological findings using MITS as part of a cause of death analysis for stillborns and preterm neonatal deaths.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were collected during an observational multicenter prospective study called the Project to Understand and Research Preterm birth and Stillbirth (PURPOSe) conducted in India and Pakistan. After obtaining written informed consent from parents, the eligible stillbirths and neonatal deaths were subjected to MITS using a standard protocol. The tissues were obtained from both lungs for histological and microbiological analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At both sites, a total of 453 stillbirths and 352 neonatal deaths underwent MITS. For stillbirths and neonatal deaths, the yield of lung tissue using MITS was high (92%). Intrauterine fetal distress and respiratory distress syndrome were the leading lung pathologies reported in stillbirths and neonatal deaths, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MITS appears to be a reasonable alternative to CDA in obtaining and evaluating lung tissue to inform accurate cause of death analysis in stillbirth and preterm deaths.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab846","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T11:55:28Z","timestamp":1632225328000},"page":"S430-S434","source":"Crossref","is-referenced-by-count":4,"title":["Lung Findings in Minimally Invasive Tissue Sampling (MITS) Examinations of Fetal and Preterm Neonatal Deaths: A Report From the PURPOSe Study"],"prefix":"10.1093","volume":"73","author":[{"given":"Gowdar","family":"Guruprasad","sequence":"first","affiliation":[{"name":"Department of Neonatology, JJM Medical College, Davangere, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangappa","family":"Dhaded","sequence":"additional","affiliation":[{"name":"Women\u2019s and Children\u2019s Health Research Unit, Jawaharlal Nehru Medical College, Belagavi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Yogesh Kumar","sequence":"additional","affiliation":[{"name":"Women\u2019s and Children\u2019s Health Research Unit, Jawaharlal Nehru Medical College, Belagavi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjunath S","family":"Somannavar","sequence":"additional","affiliation":[{"name":"Women\u2019s and Children\u2019s Health Research Unit, Jawaharlal Nehru Medical College, Belagavi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivaprasad S","family":"Goudar","sequence":"additional","affiliation":[{"name":"Women\u2019s and Children\u2019s Health Research Unit, Jawaharlal Nehru Medical College, Belagavi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vardendra","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Pathology, JJM Medical College, Davangere, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology, JJM Medical College, Davangere, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T S","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"Department of Pathology, JJM Medical College, Davangere, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeesham","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khurram","family":"Minhas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afia","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyam Sunder","family":"Tikmani","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Hwang","sequence":"additional","affiliation":[{"name":"Social, Statistical, and Environmental Sciences, RTI International, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Aceituno","sequence":"additional","affiliation":[{"name":"Social, Statistical, and Environmental Sciences, RTI International, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M","family":"McClure","sequence":"additional","affiliation":[{"name":"Social, Statistical, and Environmental Sciences, RTI International, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University, New York, New York, 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