{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:21:22Z","timestamp":1771611682807,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Age-specific incidence of acute myocarditis\/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis\/pericarditis among Hong Kong adolescents following Comirnaty vaccination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis\/pericarditis in adolescents following Comirnaty vaccination were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis\/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis\/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis\/pericarditis was 18.52 (95% confidence interval [CI], 11.67\u201329.01) per 100\u00a0000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12\u20139.51) and 21.22 (95% CI, 13.78\u201332.28 per 100\u00a0000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38\u201312.53) and 37.32 (95% CI, 26.98\u201351.25) per 100\u00a0000 persons vaccinated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There is a significant increase in the risk of acute myocarditis\/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciab989","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T12:16:18Z","timestamp":1637842578000},"page":"673-681","source":"Crossref","is-referenced-by-count":104,"title":["Epidemiology of Acute Myocarditis\/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0333-0059","authenticated-orcid":false,"given":"Gilbert T","family":"Chua","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong , Hong Kong SAR , China"},{"name":"Department of Paediatrics, Hong Kong Children\u2019s Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike Yat Wah","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Princess Margaret Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine S L","family":"Chui","sequence":"additional","affiliation":[{"name":"School of Nursing, The University of Hong Kong , Hong Kong SAR , China"},{"name":"School of Public Health, The University of Hong Kong , Hong Kong SAR , China"},{"name":"Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert David","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Nursing, The University of Hong Kong , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund Chi Lok","family":"Cheung","sequence":"additional","affiliation":[{"name":"Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Ma","sequence":"additional","affiliation":[{"name":"Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam T Y","family":"Leung","sequence":"additional","affiliation":[{"name":"Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR , China"},{"name":"Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina Siu Ling","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong , Hong Kong SAR , China"},{"name":"Department of Paediatrics, Hong Kong Children\u2019s Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hong Kong Children\u2019s Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing 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Piu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua Sung Chih","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Princess Margaret Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Kit","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Princess Margaret Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Chiu","family":"Shek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Princess Margaret Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes Sze Yin","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chit Kwong","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, United Christian Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Wah","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Tuen Mun Hospital , Hong Kong SAR , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, Caritas Medical Centre , Hong Kong SAR , China"},{"name":"Department of Radiology, North Landau Hospital , Hong Kong SAR , China"},{"name":"Department of Radiology, Princess Margaret 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