{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:08:14Z","timestamp":1788998894727,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Disseminated gonococcal infections (DGIs) are thought to be uncommon; surveillance is limited, and case reports are analyzed retrospectively or in case clusters. We describe the population-level burden of culture-confirmed DGIs through the Active Bacterial Core surveillance (ABCs) system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>During 2015\u20132016, retrospective surveillance was conducted among residents in 2 ABCs areas and prospectively in 3 ABCs areas during 2017\u20132019. A DGI case was defined as isolation of Neisseria gonorrhoeae from a normally sterile site. A case report form was completed for each case and antimicrobial susceptibility testing (AST) was performed on available isolates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During 2015\u20132019, 77 DGI cases were identified (a rate of 0.13 cases per 100\u00a0000 population) and accounted for 0.06% of all reported gonorrhea cases in the 3 surveillance areas. Most DGI cases were male (64%), non-Hispanic Black (68%), and ranged from 16 to 67 years of age; blood (55%) and joint (40%) were the most common sterile sites. Among 29 isolates with AST results during 2017\u20132019, all were susceptible to ceftriaxone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>DGI is an infrequent complication of N gonorrhoeae; because it can quickly develop antimicrobial resistance, continued DGI surveillance, including monitoring trends in antimicrobial susceptibility, could help inform DGI treatment recommendations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac052","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T12:13:46Z","timestamp":1643285626000},"page":"953-958","source":"Crossref","is-referenced-by-count":31,"title":["Surveillance for Disseminated Gonococcal Infections, Active Bacterial Core Surveillance (ABCs)\u2014United States, 2015\u20132019"],"prefix":"10.1093","volume":"75","author":[{"given":"Emily J","family":"Weston","sequence":"first","affiliation":[{"name":"Division of STD Prevention (DSTDP) National Center for HIV\/AIDS, Viral Hepatitis, STDs, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke L","family":"Heidenga","sequence":"additional","affiliation":[{"name":"California Emerging Infections Program , Oakland, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M","family":"Farley","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Department of Medicine , Atlanta, Georgia , USA"},{"name":"Atlanta VA Medical Center , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Tunali","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Department of Medicine , Atlanta, Georgia , USA"},{"name":"Atlanta VA Medical Center , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Tobin","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Georgia Department of Public Health , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Moore","sequence":"additional","affiliation":[{"name":"Georgia Department of Public Health , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Workowski","sequence":"additional","affiliation":[{"name":"Division of STD Prevention (DSTDP) National Center for HIV\/AIDS, Viral Hepatitis, STDs, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention , Atlanta, Georgia , USA"},{"name":"Emory University School of Medicine, Department of Medicine , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H","family":"Raphael","sequence":"additional","affiliation":[{"name":"Division of STD Prevention (DSTDP) National Center for HIV\/AIDS, Viral Hepatitis, STDs, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillard","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Division of STD Prevention (DSTDP) National Center for HIV\/AIDS, Viral Hepatitis, STDs, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Torrone","sequence":"additional","affiliation":[{"name":"Division of STD Prevention (DSTDP) National Center for HIV\/AIDS, Viral Hepatitis, STDs, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"2022092921002772300_CIT0001","volume-title":"Sexually transmitted disease surveillance 2018","author":"Centers for Disease Control and Prevention.","year":"2019"},{"key":"2022092921002772300_CIT0002","first-page":"627","volume-title":"Sexually transmitted diseases","author":"Hook","year":"2008"},{"key":"2022092921002772300_CIT0003","first-page":"1","article-title":"Centers for disease control and prevention. 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Bacteriology, epidemiology, host factors, pathogen factors, and pathology.","volume":"10","author":"Eisenstein","year":"1981","journal-title":"Semin Arthritis Rheum"},{"key":"2022092921002772300_CIT0009","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/pathogens9020091","article-title":"The laboratory diagnosis of Neisseria gonorrhoeae: current testing and future demands.","volume":"9","author":"Meyer","year":"2020","journal-title":"Pathogens"},{"key":"2022092921002772300_CIT0010","first-page":"1","article-title":"Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae\u20142014.","volume":"63","author":"Papp","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2022092921002772300_CIT0011","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00005792-198409000-00001","article-title":"Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency.","volume":"63","author":"Ross","year":"1984","journal-title":"Medicine"},{"key":"2022092921002772300_CIT0012","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.idc.2005.07.003","article-title":"Gonococcal arthritis (disseminated gonococcal infections).","volume":"19","author":"Rice","year":"2005","journal-title":"Infect Dis Clin North Am"},{"key":"2022092921002772300_CIT0013","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/AOG.0b013e318244eda9","article-title":"Disseminated gonococcal infection in women.","volume":"119","author":"Bleich","year":"2012","journal-title":"Obstet Gynecol"},{"key":"2022092921002772300_CIT0014","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3947\/ic.2015.47.1.60","article-title":"Disseminated gonococcal infection presenting as bacteremia and liver abscesses in a healthy adult.","volume":"47","author":"Lee","year":"2015","journal-title":"Infect Chemother"},{"key":"2022092921002772300_CIT0015","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.12659\/AJCR.906393","article-title":"Fitz-hugh-curtis syndrome caused by gonococcal infection in a patient with systemic lupus erythematous: a case report and literature review.","volume":"18","author":"Rueda","year":"2017","journal-title":"Am J Case Rep"},{"key":"2022092921002772300_CIT0016","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/jcp.48.1.86","article-title":"Acute gonococcal arthritis: an unusual host and pathogen combination.","volume":"48","author":"Lewis","year":"1995","journal-title":"J Clin Pathol"},{"key":"2022092921002772300_CIT0017","first-page":"S157","article-title":"Identifying disseminated gonococcal infection in the North Carolina electronic disease surveillance system, 2014-2019. Presented virtually at the 2020 STD Prevention Conference, September 14-24, 2020.","volume":"47","author":"Cope","year":"2016","journal-title":"Sex Trans Dis"},{"key":"2022092921002772300_CIT0018","first-page":"S160","article-title":"Identification of suspected disseminated gonococcal infections from STD Surveillance System Data in Virginia, 2018-2019. Presented virtually at the 2020 STD Prevention Conference, September 14-24, 2020.","volume":"47","author":"Vasiliu","year":"2016","journal-title":"Sex Trans Dis"},{"key":"2022092921002772300_CIT0019","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1136\/sextrans-2013-051119","article-title":"Changing patterns of disseminated gonococcal infection in France: cross-sectional data 2009-2011.","volume":"89","author":"Belkacem","year":"2013","journal-title":"Sex Trans Infect"},{"key":"2022092921002772300_CIT0020","first-page":"S126","article-title":"Characterization of a cluster of disseminated gonococcal infections in one California county using clinical data, case investigation, and whole genome sequencing. 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