{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:37:09Z","timestamp":1790289429517,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Folktandv\u00e5rden Stockholm AB"},{"DOI":"10.13039\/501100005300","name":"Swedish Dental Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005300","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A few years after the publication of the British guidelines, national recommendations were published by the Swedish Medical Products Agency in October 2012, promoting the cessation of antibiotic prophylaxis in dentistry for the prevention of infective endocarditis (IE). The aim of this study was to evaluate whether the incidence of oral streptococcal IE increased among high-risk individuals after October 2012.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This nationwide cohort study included all adult individuals (&amp;gt;17 years) living in Sweden from January 2008 to January 2018, with a diagnose code or surgical procedure code indicating high risk of IE. Cox proportional hazard models were performed to calculate adjusted ratios of oral streptococcal IE before and after October 2012 between high-risk individuals and references.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>This study found no increased incidence of oral streptococcal IE among high-risk individuals during the 5 years after the cessation, compared with before. Hazard rate ratios were 15.4 (95% confidence interval [CI]: 8.3\u201328.5) before and 20.7 (95% CI: 10.0\u201342.7) after October 2012 for prevalent high-risk individuals. Corresponding ratios for incident high-risk individuals were 66.8 (95% CI: 28.7\u2013155.6) and 44.6 (95% CI: 22.9\u201386.9). Point estimates for interaction with time period were 1.4 (95% CI: .6\u20133.5) and 0.8 (95% CI: .5\u20131.3) for prevalent and incident high-risk individuals, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The results suggest that the current Swedish recommendation not to administer antibiotic prophylaxis for the prevention of IE in dentistry has not led to an increased incidence of oral streptococcal IE among high-risk individuals.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cid\/ciac095","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T12:14:30Z","timestamp":1643717670000},"page":"1171-1178","source":"Crossref","is-referenced-by-count":13,"title":["Infective Endocarditis Among High-risk Individuals Before and After the Cessation of Antibiotic Prophylaxis in Dentistry: A National Cohort Study"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-484X","authenticated-orcid":false,"given":"Niko","family":"V\u00e4h\u00e4sarja","sequence":"first","affiliation":[{"name":"Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet , Huddinge , Sweden"},{"name":"Department of Oral and Maxillofacial Surgery, Eastmaninstitutet, Folktandv\u00e5rden Stockholms L\u00e4n AB, Folktandv\u00e5rden Eastmaninstitutet , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil","family":"Lund","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet , Huddinge , Sweden"},{"name":"Medical Unit for Reconstructive Plastic- and Craniofacial Surgery, Karolinska University Hospital , Stockholm , 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Huddinge , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Warnqvist","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet , Solna , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Kr\u00fcger Weiner","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet , Huddinge , Sweden"},{"name":"Department of Oral and Maxillofacial Surgery, Eastmaninstitutet, Folktandv\u00e5rden Stockholms L\u00e4n AB, Folktandv\u00e5rden Eastmaninstitutet , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Naimi-Akbar","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet , Huddinge , Sweden"},{"name":"Department of Oral and Maxillofacial Surgery, Eastmaninstitutet, Folktandv\u00e5rden Stockholms L\u00e4n AB, Folktandv\u00e5rden Eastmaninstitutet , Stockholm , Sweden"},{"name":"Health Technology Assessment-Odontology (HTA-O), Faculty of Odontology, Malm\u00f6 University , Malm\u00f6 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"2022093020251506000_CIT0001","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/eurheartj\/ehx682","article-title":"Incidence of infective endocarditis among patients considered at high risk.","volume":"39","author":"\u00d8stergaard","year":"2018","journal-title":"Eur Heart J"},{"key":"2022093020251506000_CIT0002","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0891-5520(20)30502-X","article-title":"Risk factors for infective endocarditis.","volume":"7","author":"Steckelberg","year":"1993","journal-title":"Infect Dis Clin North 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